Property and Equipment, Net - Summary of Property and Equipment and Related Accumulated Depreciation and Amortization (Detail) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 47,538	$ 49,681
Less accumulated depreciation and amortization	(33,465)	(32,415)
Total property and equipment, net	14,088	17,281
Computer Equipment and Software [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	1,704	1,704
Furniture and Fixtures [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	2,723	2,723
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	27,659	29,521
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	15,452	15,733
Construction in Progress [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, net	$ 15	$ 15