Income Taxes - Components of the Net Deferred Tax Assets/Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Federal and state net operating loss carryforwards	$ 97,575	$ 74,278
Research and development tax credits	12,271	9,247
Lease liabilities	7,684	7,327
Accruals and other	3,184	3,354
Amortization	10,633	11,155
Deferred revenue	2,537	3,414
Gross deferred tax assets	133,884	108,775
Valuation allowance	(127,007)	(101,781)
Net deferred tax assets	6,877	6,994
Deferred tax liabilities:
Other depreciation	(212)	(763)
Operating lease right-of-use assets	(6,665)	(6,231)
Deferred tax assets, net of allowance	$ 0	$ 0