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Number of fully vested and expected to vest exercisable options that may be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Per share or per unit amount of equity securities issued.

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Equity - Additional Information (Details) $ / shares in Units, $ in Millions		1 Months Ended			12 Months Ended
	Jan. 01, 2020	Sep. 30, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Mar. 31, 2018 shares	Dec. 31, 2022 USD ($) vote $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2019 shares	Aug. 31, 2021 USD ($)	Oct. 31, 2019 USD ($)	Sep. 30, 2018 shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock, shares authorized (in shares) \| shares					200,000,000	200,000,000
Common stock, par value (in usd per share) \| $ / shares					$ 0.001	$ 0.001
Number of votes per common stock share held \| vote					1
Gross proceeds						$ 259.9	$ 431.9
Fees and expenses					$ 0.0	4.6	27.7
Compensation expense, total					75.5	$ 57.1	$ 30.2
Compensation expense not yet recognized					$ 67.3
Weighted average grant date fair value of options granted (in usd per share) \| $ / shares					$ 39.17	$ 52.85	$ 27.45
Intrinsic value of options exercised					$ 7.9	$ 46.9	$ 19.4
ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock reserved for issuance (in shares) \| shares											311,850
Common stock reserved for issuance on outstanding common stock (percentage)	1.00%
Common stock, shares remained available for purchase and issuance \| shares					1,986,565
Common stock, shares issued \| shares					24,898	19,357	11,046
2018 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock reserved for issuance (in shares) \| shares											4,067,007
Common stock, shares remained available for purchase and issuance \| shares					2,048,284
Annual increase in reserved shares of outstanding common stock (percentage)								4.00%
Compensation expense not yet recognized, period of recognition (in years)					1 year 7 months 6 days
Compensation expense for options not yet recognized					$ 53.8
Stock options vested and expected to vest (in shares) \| shares					6,540,844
Restricted stock units expected to vest (in shares) \| shares					414,450
2018 Plan \| Restricted stock units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Compensation expense not yet recognized					$ 13.5
Compensation expense not yet recognized, period of recognition (in years)					2 years 1 month 6 days
2018 Plan \| ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Compensation expense, total					$ 0.7	$ 0.3	$ 0.3
Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Incentive units authorized for issuance (in shares) \| shares				6,199,477
Minimum \| 2018 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Annual increase in reserved shares of common stock \| shares								4,989,593
Minimum \| Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based award, vesting period (years)				1 year
Maximum \| 2018 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock reserved for issuance (in shares) \| shares											1,277,181
Maximum \| Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based award, vesting period (years)				4 years
Weighted Average
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Compensation expense not yet recognized, period of recognition (in years)					1 year 8 months 12 days
At The Market Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Gross proceeds							64.1
Fees and expenses					$ 0.0	$ 0.0	$ 1.6
Equity Distribution Agreement \| Piper Sandler \| At The Market Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares, issued and sold \| shares							2,593,637
Common stock aggregate offering price										$ 100.0
Proceeds from sale of common stock							$ 64.1
Fees and expenses							$ 1.6
Common Shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares, issued and sold \| shares			6,571,428			3,500,000	6,600,000
Share price, issued and sold (in usd per share) \| $ / shares			$ 70.00				$ 70.00
Gross proceeds from sale of shares in Initial public offering before fees and expenses			$ 460.0
Fees and expenses			$ 28.1
Common Shares \| At The Market Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares, issued and sold \| shares							2,500,000
Common Shares \| Stock Purchase Agreement \| Pfizer, Inc.
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares, issued and sold \| shares		3,457,815
Share price, issued and sold (in usd per share) \| $ / shares		$ 101.22
Gross proceeds		$ 350.0
Financial advisor fees		$ 4.6
Common Shares \| Equity Distribution Agreement \| Piper Sandler \| At The Market Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares, issued and sold \| shares					0	0
Common stock aggregate offering price									$ 300.0