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Leases - Additional Information (Detail)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Nov. 30, 2020
Sep. 30, 2020
USD ($)
Apr. 30, 2019
USD ($)
Mar. 31, 2019
Jan. 31, 2016
USD ($)
Oct. 31, 2014
USD ($)
Dec. 31, 2020
USD ($)
Mar. 31, 2020
USD ($)
Dec. 31, 2020
USD ($)
ft²
USD_per_sqft
Dec. 31, 2019
USD ($)
Lessee Lease Description [Line Items]                    
Increase in operating lease right-of-use assets   $ 400             $ (6,457) $ (5,728)
Increase in operating lease, liability   $ 400                
Operating lease right-of-use assets             $ 39,114   39,114 $ 19,137
Operating lease, liability             $ 39,305   $ 39,305  
130 Brookline Street [Member]                    
Lessee Lease Description [Line Items]                    
Operating lease, description                 In October 2014, the Company entered into an agreement to lease office and laboratory space at 130 Brookline Street (the “130 Brookline Lease”) in Cambridge, Massachusetts under an operating lease agreement with a term through January 2020, with an option to extend the term of the lease for an additional five-year period. In April 2019, the Company executed an amendment to the lease to extend the term of the lease for the additional five-year period, through January 2025.  
Operating lease expiration           2020-01        
Lessee operating lease extended expiration date     Jan. 31, 2025              
Operating lease, existence of option to extend           true        
Operating lease, options to extend                 option to extend the term of the lease for an additional five-year period. In April 2019, the Company executed an amendment to the lease to extend the term of the lease for the additional five-year period, through January 2025.  
Operating lease, renewal term     5 years     5 years        
Lessee operating sublease option to extend                 two options to extend the agreement by one year each, for a total option period of up to two years.  
Operating sublease expiration       2021-04            
Operating sublease, existence of option to extend       true            
Operating lease right-of-use assets     $ 1,300              
Operating lease, liability     $ 1,300              
130 Brookline Street [Member] | Maximum [Member]                    
Lessee Lease Description [Line Items]                    
Operating sublease, renewal term       2 years            
130 Brookline Street [Member] | Second Amendment [Member]                    
Lessee Lease Description [Line Items]                    
Operating lease, description                 In March 2020, the Company entered into a second amendment to the 130 Brookline Lease (the “130 Brookline Lease Second Amendment”). The 130 Brookline Lease Second Amendment amends certain terms of the Company’s existing lease, dated October 21, 2014, as amended on April 5, 2019. The 130 Brookline Lease Second Amendment extends the term of the 130 Brookline Lease by approximately six years through January 31, 2031.  
Lessee operating lease extended expiration date                 Jan. 31, 2031  
Operating lease, existence of option to extend                 true  
Operating lease, options to extend                 an option to extend the lease for two consecutive five-year terms.  
Operating lease, renewal term             6 years   6 years  
Increase in operating lease right-of-use assets               $ 7,300    
Increase in operating lease, liability               $ 7,300    
130 Brookline Street [Member] | Other Assets [Member]                    
Lessee Lease Description [Line Items]                    
Lease security deposit           $ 300        
40 Erie Street [Member]                    
Lessee Lease Description [Line Items]                    
Operating lease, description                 In January 2016, the Company entered into a ten-year agreement to lease office and laboratory space at 40 Erie Street (the “40 Erie Lease”) in Cambridge, Massachusetts under an operating lease agreement, with an option to terminate the lease at the end of the sixth year and an option to extend the term of the lease for an additional three years.  
Operating lease, existence of option to extend         true          
Operating lease, options to extend                 option to extend the term of the lease for an additional three years.  
Operating lease, renewal term         3 years          
Operating lease, term of contract         10 years          
Operating lease, existence of option to terminate         true          
Operating lease, option to terminate                 option to terminate the lease at the end of the sixth year  
Operating lease, terminate term         6 years          
40 Erie Street [Member] | Second Amendment [Member]                    
Lessee Lease Description [Line Items]                    
Operating lease, description                 In November 2020, the Company entered into a second amendment to the 40 Erie Lease (the “40 Erie Lease Second Amendment”). The 40 Erie Street Second Amendment amends certain terms of the Company’s existing lease, dated January 6, 2016, as amended on November 12, 2020. The 40 Erie Lease Second Amendment provides the Company with a right of first offer with respect to any space that becomes available at the 40 Erie Street building, and in consideration for this right the Company has agreed to nullify the option to terminate the lease at the end of the sixth year that was included in the 40 Erie Lease.  
Operating lease, existence of option to extend true                  
Increase in operating lease right-of-use assets             $ 18,500      
Increase in operating lease, liability             $ 18,500      
Operating lease, option to terminate                 option to terminate the lease at the end of the sixth year  
Operating lease, terminate term 6 years                  
40 Erie Street [Member] | Other Assets [Member]                    
Lessee Lease Description [Line Items]                    
Lease security deposit         $ 2,200          
Albany Lease [Member]                    
Lessee Lease Description [Line Items]                    
Area of space leased | ft²                 39,000  
Operating lease, description                 In March 2020, the Company entered into an agreement to lease approximately 39,000 square feet of office and laboratory space at 281 Albany Street in Cambridge, Massachusetts under an operating lease agreement (the “281 Albany Lease”). The Company’s obligation to pay rent will start on the date that is six months after the commencement date or the date on which the Company occupies the premises, whichever occurs earlier (the “Rent Commencement Date”).  
Term of lease             10 years   10 years  
Base rent per square foot for first year | USD_per_sqft                 99.00  
Base rent per square foot for last year | USD_per_sqft                 128.87  
Amount receivable on cost of construction and tenant improvement                 $ 4,400  
Letter of credit             $ 1,900   $ 1,900  
Operating lease, existence of option to extend                 true  
Operating lease, options to extend                 The Company has the option to extend the 281 Albany Lease for two successive five-year terms.