The following tables present changes in stockholders’ equity for the nine months ended September 30, 2019 and 2018 (in thousands, except share data):

						Additional		Accumulated Other						Total
	Common					Paid-In		Comprehensive			Accumulated			Stockholders’
	Shares			Amount		Capital		(Loss) Income			Deficit			Equity
Balance at December 31, 2018		45,224,480		$	5	$	478,968	$	(28	)	$	(201,025	)	$	277,920
Retroactive adjustment to beginning accumulated deficit for adoption of ASC 842		-			-		-		-			(320	)		(320	)
Issuance of common stock through at-the-market offerings, net of issuance costs of $120		223,818			-		3,639		-			-			3,639
Exercise of stock options		30,800			-		360		-			-			360
Equity-based compensation		-			-		4,592		-			-			4,592
Other comprehensive gain		-			-		-		87			-			87
Net loss		-			-		-		-			(21,940	)		(21,940	)
Balance at March 31, 2019		45,479,098			5		487,559		59			(223,285	)		264,338
Issuance of common stock through at-the-market offerings, net of issuance costs of $3		1,986,579			-		31,413		-			-			31,413
Exercise of stock options		203,072			-		1,664		-			-			1,664
Issuance of shares under employee stock purchase plan		45,826			-		534		-			-			534
Equity-based compensation		-			-		4,404		-			-			4,404
Other comprehensive gain		-			-		-		196			-			196
Net loss		-			-		-		-			(25,683	)		(25,683	)
Balance at June 30, 2019		47,714,575			5		525,574		255			(248,968	)		276,866
Issuance of common stock through at-the-market offerings, net of issuance costs of $199		1,141,411			-		19,068		-			-			19,068
Exercise of stock options		21,311			-		192		-			-			192
Equity-based compensation		-			-		3,079		-			-			3,079
Other comprehensive gain		-			-		-		81			-			81
Net loss		-			-		-		-			(23,634	)		(23,634	)
Balance at September 30, 2019		48,877,297		$	5	$	547,913	$	336		$	(272,602	)	$	275,652

						Additional		Accumulated Other						Total
	Common					Paid-In		Comprehensive			Accumulated			Stockholders’
	Shares			Amount		Capital		(Loss) Income			Deficit			Equity
Balance at December 31, 2017		42,384,623		$	4	$	421,706	$	-		$	(121,113	)	$	300,597
Retroactive adjustment to beginning accumulated deficit for adoption of ASU 2014-09		-			-		-		-			5,431			5,431
Exercise of stock options		709,321			-		6,720		-			-			6,720
Cancellation of restricted stock		(2,022	)		-		-		-			-			-
Equity-based compensation		-			-		4,107		-			-			4,107
Net loss		-			-		-		-			(21,356	)		(21,356	)
Balance at March 31, 2018		43,091,922			4		432,533		-			(137,038	)		295,499
Exercise of stock options		68,163			-		557		-			-			557
Issuance of shares under employee stock purchase plan		32,707			-		598		-			-			598
Cancellation of restricted stock		(4,780	)		-		-		-			-			-
Equity-based compensation		-			-		4,901		-			-			4,901
Net loss		-			-		-		-			(22,219	)		(22,219	)
Balance at June 30, 2018		43,188,012			4		438,589		-			(159,257	)		279,336
Exercise of stock options		204,658			-		2,180		-			-			2,180
Cancellation of restricted stock		(23,347	)		-		-		-			-			-
Equity-based compensation		-			-		4,456		-			-			4,456
Net loss		-			-		-		-			(22,702	)		(22,702	)
Balance at September 30, 2018		43,369,323		$	4	$	445,225	$	-		$	(181,959	)	$	263,270

On October 12, 2018, the Company filed a Registration Statement on Form S-3 (the “2018 Shelf”) with the SEC in relation to the registration of common stock, preferred stock, warrants and units of any combination thereof for the purposes of selling, from time to time, its common stock, convertible securities or other equity securities in one or more offerings. The Company also simultaneously entered into an Open Market Sale Agreement (the “2018 Sales Agreement”) with Jefferies LLC, (the “Sales Agent”), to provide for the offering, issuance and sale by the Company of up to an aggregate amount of $100.0 million of its common stock from time to time in “at-the-market” offerings under the 2018 Shelf and subject to the limitations thereof. The Company will pay to the Sales Agent cash commissions of 3.0 percent of the gross proceeds of sales of common stock under the 2018 Sales Agreement. In November 2018, the Company issued 1,659,300 shares of its common stock at $18.00 per share in accordance with the 2018 Sales Agreement for net proceeds of $28.5 million, after payment of cash commissions to the Sales Agent and approximately $0.4 million related to legal, accounting and other fees in connection with the sales. During the nine months ended September 30, 2019, the Company issued an additional 3,351,808 shares of its common stock, in a series of sales, at an average price of $16.75 per share, in accordance with the 2018 Sales Agreement, for aggregate net proceeds of $54.1 million, after payment of cash commissions to the Sales Agent and approximately $0.2 million related to legal, accounting and other fees in connection with the sales. As of September 30, 2019, approximately $14.0 million in shares of common stock remain eligible for sale under the 2018 Sales Agreement.

On August 23, 2019, the Company filed a Registration Statement on Form S-3, as amended (the “2019 Shelf”) with the SEC in relation to the registration of common stock, preferred stock, warrants and units of any combination thereof. The Company also simultaneously entered into an Open Market Sale Agreement with the Sales Agent, to provide for the offering, issuance and sale by the Company of up to an aggregate amount of $150.0 million of its common stock from time to time in “at-the-market” offerings under the 2019 Shelf and subject to the limitations thereof. The Company will pay to the Sales Agent cash commissions of 3.0 percent of the gross proceeds of sales of common stock under the 2019 Sales Agreement. As of September 30, 2019, the Company has incurred approximately $0.1 million related to legal fees in connection with this agreement. The Company has not issued any shares under this offering as of September 30, 2019.