Income Taxes (Additional Information) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Tax Credit Carryforward [Line Items]
Deferred Tax Liabilities, Deferred Expense, Capitalized Research and Development Costs	$ 405,300	$ 365,800
Amortization of costs for tax purpose description	The Company will amortize these costs for tax purposes over 5 years if the research and development was performed in the U.S. and over 15 years if the research and development was performed outside the U.S.
Net operating loss carryforwards, federal	$ 1,088,400	954,000
Taxable Income available for the period the loss was generated	20 years
Research and development credit carryforwards	$ 200,816	151,333
Increase in valuation allowance	167,100	161,300	$ 150,000
Unrecognized tax benefits	$ 0
Domestic Tax Jurisdiction [Member]
Tax Credit Carryforward [Line Items]
Net operating loss carryforwards, expiration date description	begin to expire in 2034
Tax credit carryforwards, expiration date description	begin to expire in 2034
Net operating loss carryforwards, begins to expiring year	2034
State and Local Jurisdiction [Member]
Tax Credit Carryforward [Line Items]
Net operating loss carryforwards, expiration date description	begin to expire in 2034
Research and development credit carryforwards	$ 77,900	64,100
Research and development tax credits, expiration date description	begin to expire in 2029.
Research and development tax credits, expiration year	2029
Net operating loss carryforwards, begins to expiring year	2034
Operating Loss Carryforward Indefinitely [Member]
Tax Credit Carryforward [Line Items]
Net operating loss carryover, percentage of taxable income	80.00%
Operating Loss Carryforward Indefinitely [Member] | Domestic Tax Jurisdiction [Member]
Tax Credit Carryforward [Line Items]
Net operating loss carryforwards with no expiration date	$ 1,051,500
Operating Loss Carryforward Indefinitely Begins to Expire in 2034 [Member]
Tax Credit Carryforward [Line Items]
Net operating loss carryover, percentage of taxable income	100.00%
Operating Loss Carryforward Indefinitely Begins to Expire in 2034 [Member] | Domestic Tax Jurisdiction [Member]
Tax Credit Carryforward [Line Items]
Net operating loss carryforwards, with expiration date	$ 36,900
Operating Loss Carryforward Indefinitely Begins to Expire in 2034 [Member] | State and Local Jurisdiction [Member]
Tax Credit Carryforward [Line Items]
Net operating loss carryforwards, with expiration date	1,079,200	922,800
Tax Carryforwards Begin to Expire in 2034 [Member] | Domestic Tax Jurisdiction [Member]
Tax Credit Carryforward [Line Items]
Tax credit carryforwards, with expiration date	$ 139,300	$ 100,700