Summary of Significant Accounting Policies - Summary Of Reportable Segment (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Segment Reporting Information [Line Items]
Collaboration revenue	$ 57,877	$ 36,275	$ 52,121
Type of Revenue [Extensible List]	us-gaap:LicenseAndServiceMember	us-gaap:LicenseAndServiceMember	us-gaap:LicenseAndServiceMember
Research and development	$ 466,311	$ 435,069	$ 419,979
General and administrative	125,829	116,497	90,306
Interest income	(47,807)	(49,832)	(8,542)
Loss from equity method investment	0	15,633	11,079
Net loss	(519,021)	(481,192)	(474,186)
Operating Segments [Member]
Segment Reporting Information [Line Items]
Collaboration revenue	$ 57,877	$ 36,275	$ 52,121
Type of Revenue [Extensible List]	us-gaap:LicenseAndServiceMember	us-gaap:LicenseAndServiceMember	us-gaap:LicenseAndServiceMember
Research and development	$ 466,311	$ 435,069	$ 419,979
General and administrative	125,829	116,497	90,306
Interest income	(47,807)	(49,832)	(8,542)
Loss from equity method investment	0	15,633	11,079
Other segment information	32,565	100	13,485
Net loss	(519,021)	(481,192)	(474,186)
Nex-z [Member] | Operating Segments [Member]
Segment Reporting Information [Line Items]
Research and development	69,793	54,454	37,849
NTLA-2002 [Member] | Operating Segments [Member]
Segment Reporting Information [Line Items]
Research and development	42,173	24,560	11,611
NTLA-3001 [Member] | Operating Segments [Member]
Segment Reporting Information [Line Items]
Research and development	8,709	17,312	11,506
Other Research And Development [Member] | Operating Segments [Member]
Segment Reporting Information [Line Items]
Research and development	$ 345,636	$ 338,743	$ 359,013