Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2024

Accounting Policies [Abstract]

Summary of Property and Equipment at Cost and Recognizes Depreciation and Amortization Using the Straight-Line Method Over Estimated Useful Lives

The Company records property and equipment at cost and recognizes depreciation and amortization using the straight-line method over the following estimated useful lives of the respective assets:

Asset Category	Useful Life
Laboratory equipment	5 years
Office furniture and equipment	5 years
Computer software	3 years
Computer equipment	3 years
Leasehold improvements	Shorter of useful life or remaining lease term

Expenditures for repairs and maintenance of assets are expensed as incurred. Upon retirement or sale, the cost of assets disposed and the corresponding accumulated depreciation are removed from the related accounts and any resulting gain or loss is reflected in the results of operations

Schedule Of Segment Reporting

The following table summarizes the reportable segment’s financial information:

	Year Ended December 31,
	2024			2023			2022
Collaboration revenue	$	57,877		$	36,275		$	52,121
Less:
Research and development:
External development expenses - Nex-z		69,793			54,454			37,849
External development expenses - NTLA-2002		42,173			24,560			11,611
External development expenses - NTLA-3001		8,709			17,312			11,506
Other research and development (1)		345,636			338,743			359,013
Total research and development		466,311			435,069			419,979
General and administrative (2)		125,829			116,497			90,306
Interest income		(47,807	)		(49,832	)		(8,542	)
Loss from equity method investment		-			15,633			11,079
Other segment information (3)		32,565			100			13,485
Segment and consolidated net loss	$	(519,021	)	$	(481,192	)	$	(474,186	)

(1)Includes unallocated research and development expenses including stock-based compensation of $94.2 million, $82.2 million and $56.3 million for the years ended December 31, 2024, 2023 and 2022, respectively, as disclosed within Note 12, “Stock-Based Compensation.”

(2)Includes stock-based compensation of $60.0 million, $51.8 million and $35.1 million for the years ended December 31, 2024, 2023 and 2022, respectively, as disclosed within Note 12, “Stock-Based Compensation.”

(3)Includes change in fair value of investments and change in fair value of contingent consideration, as disclosed on the Company’s consolidated statements of operations and comprehensive loss.