Leases - Additional Information (Detail) $ in Thousands	1 Months Ended							12 Months Ended
	Jun. 30, 2023 ft²	Jan. 31, 2023 ft²	Feb. 28, 2022 USD ($) ft²	Nov. 30, 2020	Mar. 31, 2019	Jan. 31, 2016	Oct. 31, 2014	Dec. 31, 2023 USD ($) ft²	Dec. 31, 2021	Dec. 31, 2022 USD ($)
Lessee Lease Description [Line Items]
Operating lease right-of-use assets | $								$ 115,375		$ 133,076
Total operating lease liabilities at December 31, 2023 | $								$ 115,346
130 Brookline Street [Member]
Lessee Lease Description [Line Items]
Operating sublease, existence of option to extend					true
Operating lease, existence of option to terminate							true
130 Brookline Street [Member] | Second Amendment [Member]
Lessee Lease Description [Line Items]
Operating lease, existence of option to extend									true
40 Erie Street [Member]
Lessee Lease Description [Line Items]
Operating lease, existence of option to extend						true
Operating lease, existence of option to terminate						true
Operating lease, terminate term						6 years
40 Erie Street [Member] | Second Amendment [Member]
Lessee Lease Description [Line Items]
Operating lease, existence of option to extend				true
Operating lease, terminate term				6 years
Albany Lease [Member]
Lessee Lease Description [Line Items]
Operating lease, existence of option to extend									true
840 Winter Street Lease [Member]
Lessee Lease Description [Line Items]
Operating lease, existence of option to extend			true
Operating lease, options to extend			The Company has the option to extend the 840 Winter Lease for two five-year terms.
Operating lease, term of contract			144 months
Area of space leased | ft²			140,000
Payments for rent | $			$ 146,000
Lease term			144 months
Operating lease, description			In February 2022, the Company entered into an agreement to lease approximately 140,000 square feet of office, general laboratory and planned good manufacturing practice (“GMP”) manufacturing space at 840 Winter Street in Waltham
Tenant improvement allowance per rentable square foot | ft²	400
Cambridge [Member]
Lessee Lease Description [Line Items]
Area of space leased | ft²		13,000						230,000