Equity-Method Investment and Other Investments - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended
	Oct. 31, 2021	Jul. 30, 2021	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Schedule of Equity Method Investments [Line Items]
Investments in and Advances to Affiliates, at Fair Value, Gross Reductions			$ 3,000
Loss from equity method investment			(2,745)	$ 0
Equity method investment			52,272		$ 58,131
Preferred Stock Purchase Agreement [Member]
Schedule of Equity Method Investments [Line Items]
Equity Method Investment, Ownership Percentage		33.33%
Preferred Stock Purchase Agreement [Member] | Cellex and BXLS [Member]
Schedule of Equity Method Investments [Line Items]
Equity Method Investment, Ownership Percentage		66.67%
AvenCell [Member]
Schedule of Equity Method Investments [Line Items]
Investment Owned, at Fair Value		$ 62,900
Loss from equity method investment			2,800
Equity method investment			52,300
AvenCell [Member] | Measurement Input, Option Volatility [Member]
Schedule of Equity Method Investments [Line Items]
Equity securities measurement input, percentage		76.00%
AvenCell [Member] | Measurement Input Option Subsequent Financing [Member]
Schedule of Equity Method Investments [Line Items]
Equity securities measurement input, percentage		75.00%
AvenCell [Member] | Measurement Input, Discount for Lack of Marketability [Member]
Schedule of Equity Method Investments [Line Items]
Equity securities measurement input, percentage		11.00%
Sparing Vision [Member]
Schedule of Equity Method Investments [Line Items]
Investment Owned, at Fair Value	$ 14,800
Sparing Vision [Member] | Series A2 Preferred Stock [Member]
Schedule of Equity Method Investments [Line Items]
Sale of Stock, Number of Shares Issued in Transaction	83,316
Sparing Vision [Member] | Measurement Input, Option Volatility [Member]
Schedule of Equity Method Investments [Line Items]
Equity securities measurement input, percentage	90.00%
Sparing Vision [Member] | Measurement Input Option Rate Of Return [Member]
Schedule of Equity Method Investments [Line Items]
Equity securities measurement input, percentage	65.00%
Kyverna Therapeutics Inc [Member]
Schedule of Equity Method Investments [Line Items]
Investment Owned, at Fair Value			$ 10,000
Kyverna Therapeutics Inc [Member] | Series B Preferred Stock [Member]
Schedule of Equity Method Investments [Line Items]
Sale of Stock, Number of Shares Issued in Transaction			3,739,515
Fair value of stock received			$ 7,000
Number of stock additionally invested			1,602,649
Cash consideration received on sale of common stock			$ 3,000