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Income Taxes - Schedule of Reconciliation of the Federal Statutory Income Tax Rate and the Company's Effective Income Tax Rate (Detail)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Federal statutory income tax rate (21.00%) (21.00%) (21.00%)
State income taxes 16.60% (7.40%) (8.90%)
Research and development tax credits 8.70% (1.80%) (5.10%)
Stock-based compensation (16.80%) (1.30%) 1.20%
162m 0.002    
Change in valuation allowance 62.90% 31.50% 33.80%