Share-Based Compensation Expense - Expense Recognized (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Share-based compensation
Compensation expense	$ 75,388	$ 65,555
Research and development
Share-based compensation
Compensation expense	34,028	30,858
Selling, general and administrative
Share-based compensation
Compensation expense	$ 41,360	$ 34,697