Collaborative and Licensing Arrangements - Assembly Biosciences, Inc. (Details) $ in Thousands	1 Months Ended		12 Months Ended
	Dec. 31, 2022 USD ($)	Jul. 31, 2020 USD ($) application	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Research and Development Arrangement, Contract to Perform for Others
Acquired in-process research and development			$ 68,665	$ 83,500	$ 109,500
Assembly Biosciences, Inc.
Research and Development Arrangement, Contract to Perform for Others
Candidates (candidates) | application		3
Acquired in-process research and development		$ 40
Maximum milestone payments		$ 503,750
Shandong Luye Pharmaceutical Co., Ltd
Research and Development Arrangement, Contract to Perform for Others
Acquired in-process research and development	$ 48,665
Payments for supplies	$ 30		$ 30