Collaborative and Licensing Arrangements - Payment Classification (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Research and development collaborative arrangements
Total	$ 74,165	$ 141,894	$ 125,300
Intangible asset | Regulatory and commercial milestone payments
Research and development collaborative arrangements
Total	0	43,394	0
Research and development expense | Upfront payments
Research and development collaborative arrangements
Total	68,665	83,500	109,500
Research and development expense | Development milestone payments
Research and development collaborative arrangements
Total	$ 5,500	$ 15,000	$ 15,800