CONSOLIDATED BALANCE SHEETS ¥ in Thousands, $ in Thousands	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Current assets:
Cash and cash equivalents	$ 3,869,564	$ 4,375,678
Short-term restricted cash	196	328
Short-term investments	665,251	2,241,962
Accounts receivable, net	173,168	483,113
Inventories	282,346	242,626
Prepaid expenses and other current assets	216,553	270,173
Total current assets	5,207,078	7,613,880
Long-term restricted cash	5,277	6,881
Property, plant and equipment, net	845,946	587,605
Operating lease right-of-use assets	109,960	117,431
Intangible assets, net	40,616	46,679
Other non-current assets	170,413	163,049
Total non-current assets	1,172,212	921,645
Total assets	6,379,290	8,535,525
Current liabilities:
Accounts payable	294,781	262,400
Accrued expenses and other payables	467,352	558,055
Deferred revenue, current portion	213,861	187,414
Tax payable	25,189	21,395
Operating lease liabilities, current portion	24,041	21,925
Research and development cost share liability, current portion	114,335	120,801
Short-term debt	328,969	427,565
Total current liabilities	1,468,528	1,599,555
Non-current liabilities:
Long-term debt	209,148	202,113
Deferred revenue, non-current portion	42,026	220,289
Operating lease liabilities, non-current portion	34,517	43,041
Deferred tax liabilities	15,996	14,169
Research and development cost share liability, non-current portion	179,625	269,561
Other long-term liabilities	46,095	54,234
Total non-current liabilities	527,407	803,407
Total liabilities	1,995,935	2,402,962
Commitments and contingencies
Equity:
Ordinary shares, 0.0001 par value per share; 9,500,000,000 shares authorized; 1,356,140,180 and 1,334,804,281 shares issued and outstanding as of December 31, 2022 and 2021, respectively	135	133
Additional paid-in capital	11,540,979	11,191,007
Accumulated other comprehensive (loss) income	(77,417)	17,950
Accumulated deficit	(7,080,342)	(5,076,527)
Total equity	4,383,355	6,132,563
Total liabilities and equity	$ 6,379,290	$ 8,535,525