Collaborative and Licensing Arrangements - Financing Liability (Details) - Amgen, Inc - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Research and Development Arrangement, Contract to Perform for Others
Research and development cost share liability, current portion	$ 120,801	$ 127,808
Research and development cost share liability, non-current portion	269,561	375,040
Total research and development cost share liability	$ 390,362	$ 502,848

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