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Research and Collaboration Arrangements - CRF Agreement - Additional Information (Details) - USD ($)
1 Months Ended 3 Months Ended
Nov. 30, 2015
Mar. 31, 2022
Dec. 31, 2021
Mar. 31, 2021
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Accounts receivable   $ 0 $ 47,000  
CRF Agreement | CRF        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Collaborative arrangement, initial research term 2 years      
Collaborative arrangement contribution upon development milestone $ 2,500,000      
Collaborative arrangement additional research term 3 years      
Collaborative arrangement achieved milestones   0    
Deferred revenue   0 $ 0  
Accounts receivable   $ 0   $ 0