Chi-Med Reports 2018 Interim Results and Updates Shareholders on
Key Clinical Programs

London: Friday, July 27, 2018: Hutchison China MediTech Limited ("Chi-Med") (AIM/Nasdaq: HCM) today announces its unaudited financial results for the six months ended June 30, 2018 and updates shareholders on key clinical programs.

The points below are selected financial data for the six months ended June 30, 2018. For more details, please refer to "Financial Review", "Operations Review" and "Unaudited Condensed Consolidated Financial Statements" below.

Innovation Platform: increased investment in Research and Development ("R&D") driven by initiation of new trials and ongoing enrollment in existing Phase III programs

Commercial Platform: strong net income growth amid shift in revenue model and over-the-counter ("OTC") logistics divestment

The points below summarize some of the pipeline development highlights so far this year. For more details, please refer to "Operations Review—Innovation Platform" below.

Fruquintinib—Highly selective tyrosine kinase inhibitor ("TKI") of vascular endothelial growth factor receptor ("VEGFR") 1/2/3:

Savolitinib—Highly selective TKI of mesenchymal epithelial transition factor ("c-MET")—Global Phase III studies underway or in planning:

Sulfatinib—Unique angio-immuno kinase inhibitor of VEGFR, fibroblast growth factor receptor ("FGFR") 1, and colony stimulating factor-1 receptor ("CSF-1R"):

Expansion of U.S. and international operations, and recruitment of key personnel:

The points below summarize some of the operational and financial highlights of our Commercial Platform in the first half of 2018. For more details, please refer to "Operations Review—Commercial Platform" below.

Scaled, high-performance drug marketing and distribution platform covering ~300 cites/towns in China with approximately 3,400 sales personnel. Targeting multiple indications with many household-name brands:

Simon To, Chairman of Chi-Med, said: "Chi-Med continues to deliver on its clear strategy of developing its broad pipeline and cultivating and growing its capabilities in global drug discovery and development, while maintaining an over a decade-and-a-half long track record of earnings growth in its Commercial Platform.

During the first half of 2018, we have focused on navigating the China NDA process for fruquintinib, which we believe is now nearing completion. We are optimistic that we will see fruquintinib approved and launched by year end. We also look forward, around year end, to reporting the top-line results for the pivotal Phase III, the FALUCA study, of fruquintinib in third-line NSCLC in China.

Our collaboration with AstraZeneca continues to gather momentum, and we are currently enrolling registration studies in both kidney and lung cancer indications for savolitinib monotherapy. We are also in the process of planning and preparing to initiate multiple additional studies in lung and gastric cancers, which we believe may ultimately serve as registration studies.

Our un-partnered assets have also made good progress, with sulfatinib in two Phase III studies in China that could produce readout next year in NETs. In addition, we have worked with key opinion leaders and the regulatory authorities in China to agree on a Phase III pathway for epitinib and aim to initiate a pivotal study around year end. On our Syk, phosphoinositide 3-kinase delta ("PI3Kd") and FGFR compounds, all of which are in proof-of-concept, we have made meaningful progress in enrollment thereby acquiring a preliminary understanding of efficacy and safety for each compound. We expect to present some of these data at scientific conferences over the next twelve months.

We are now looking closely into multiple opportunities to combine our highly selective TKIs with both PD-1 and PD-L1 immunotherapy agents and will strive to make progress during the second half of 2018, via collaboration, in this very high potential arena.

We have expanded our U.S./ex-Asia operations, including our office in New Jersey, and continue to recruit seasoned talent to manage the progress of our unpartnered compounds through proof-of-concept, registration trials, and market launch in territories outside of Asia.

Chi-Med has a clear and ambitious aim to bring three of our drugs through approval over the next approximately three years. We believe we are adequately structured and resourced to support this aim. In the longer term, we intend to continue to emerge as a world-class innovator based in China, bringing our assets to both the China and global markets. We have confidence in our ability to achieve these aims."

Use of Non-GAAP Financial Measures—References in this announcement to adjusted R&D expenses, adjusted consolidated net income attributable to Chi-Med from our Commercial Platform, adjusted consolidated operating profit from our Commercial Platform, adjusted consolidated net income attributable to Chi-Med from our Prescription Drugs business and adjusted revenue of HBYS and non-consolidated joint ventures are based on non-GAAP financial measures. Please see the "Use of Non-GAAP Financial Measures and Reconciliation" below for further information relevant to the interpretation of these financial measures and reconciliations of these financial measures to the most comparable GAAP measures, respectively.

Our updated guidance for 2018, compared to the most recent guidance in our full year results announcement for the year ended December 31, 2017 dated March 12, 2018, includes a $20 million increase in expected full year Innovation Platform R&D expense to $130-140 million. This increase reflects a rise in clinical trial spending as well as broadening of organizational scale and new middle management

share-based incentive grants. These costs are all driven by the heightened competitive environment in China biotech, resulting from the step-change increase interest and investment in the sector over the past two years. We make no other changes to the full year 2018 financial guidance as detailed below:

	2018 Previous Guidance	2018 Current Guidance	Adjustment

Group Level:
• Consolidated revenue	$155 - 175m	$155 - 175m	None
• Admin., interest & tax	$(16) - (18)m	$(16) - (18)m	None

• Net loss^[1^]	$(19) - (52)m	$(39) - (72)m	$(20)m increase
Innovation Platform:
• Consolidated revenue	$40 - 50m	$40 - 50m	None
• Adjusted (non-GAAP) R&D expenses	$(110) - (120)m	$(130) - (140)m	$(20)m increase

• Net loss^[1^]	$(60) - (80)m	$(80) - (100)m	$(20)m increase
Commercial Platform:
• Sales (consolidated)	$115 - 125m	$115 - 125m	None
• Sales of non-consolidated JVs^[2^]	$460 - 480m	$460 - 480m	None

• Net income on an as adjusted (non-GAAP) basis excl. one-time gains^[1^]	$41 - 43m	$41 - 43m	None
• One-time gains^[1^]	$0 - 20m^[3^]	$0 - 20m^[3^]	None

• Net income^[1^]	$41 - 63m	$41 - 63m	None

U.K. Analysts Meeting and Webcast Scheduled Today at 9:00 a.m. BST (4:00 p.m. HKT)—at Citigate Dewe Rogerson, 3 London Wall Buildings, London, EC2M 5SY, U.K. Investors may participate in the call at +44 20 3003 2666 or access a live video webcast of the call via Chi-Med's website at www.chi-med.com/investors/event-information/.

U.S. Conference Call Scheduled Today at 9:00 a.m. EDT—to participate in the call from the U.S., please dial 1 866 966 5335.

Additional dial-in numbers are also available at Chi-Med's website. For both calls please use conference ID "Chi-Med."

Chi-Med is an innovative biopharmaceutical company which researches, develops, manufactures and sells pharmaceuticals and healthcare products. Its Innovation Platform, Hutchison MediPharma Limited, focuses on discovering and developing innovative therapeutics in oncology and autoimmune diseases for the global market. Its Commercial Platform manufactures, markets, and distributes prescription drugs and consumer health products in China.

Chi-Med is majority owned by the multinational conglomerate CK Hutchison Holdings Limited (SEHK: 1). For more information, please visit: www.chi-med.com.

Unless the context requires otherwise, references in this announcement to the "Group," the "Company," "Chi-Med," "Chi-Med Group," "we," "us," and "our," mean Hutchison China MediTech Limited and its consolidated subsidiaries and joint ventures unless otherwise stated or indicated by context.

The performance and results of operations of the Group contained within this announcement are historical in nature, and past performance is no guarantee of future results of the Group. This announcement contains forward-looking statements within the meaning of the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by words like "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "pipeline," "could," "potential," "believe," "first-in-class," "best-in-class," "designed to," "objective," "guidance," "pursue," or similar terms, or by express or implied discussions regarding potential drug candidates, potential indications for drug candidates or by discussions of strategy, plans, expectations or intentions. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that any of our drug candidates will be approved for sale in any market, or that any approvals which are obtained will be obtained at any particular time, or that any such drug candidates will achieve any particular revenue or net income levels. In particular, management's expectations could be affected by, among other things: unexpected regulatory actions or delays or government regulation generally; the uncertainties inherent in research and development, including the inability to meet our key study assumptions regarding enrollment rates, timing and availability of subjects meeting a study's inclusion and exclusion criteria and funding requirements, changes to clinical protocols, unexpected adverse events or safety, quality or manufacturing issues; the inability of a drug candidate to meet the primary or secondary endpoint of a study; the inability of a drug candidate to

obtain regulatory approval in different jurisdictions or gain commercial acceptance after obtaining regulatory approval; global trends toward health care cost containment, including ongoing pricing pressures; uncertainties regarding actual or potential legal proceedings, including, among others, actual or potential product liability litigation, litigation and investigations regarding sales and marketing practices, intellectual property disputes, and government investigations generally; and general economic and industry conditions, including uncertainties regarding the effects of the persistently weak economic and financial environment in many countries and uncertainties regarding future global exchange rates. For further discussion of these and other risks, see Chi-Med's filings with the U.S. Securities and Exchange Commission and on AIM. Chi-Med is providing the information in this announcement as of this date and does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise.

In addition, this announcement contains statistical data and estimates that Chi-Med obtained from industry publications and reports generated by third-party market research firms. Although Chi-Med believes that the publications, reports and surveys are reliable, Chi-Med has not independently verified the data and cannot guarantee the accuracy or completeness of such data. You are cautioned not to give undue weight to this data. Such data involves risks and uncertainties and are subject to change based on various factors, including those discussed above.

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) No 596/2014.

Chi-Med Group revenue for the six months ended June 30, 2018 decreased by 19% to $102.2 million (H1 2017: $126.6m). Revenue from the Commercial Platform decreased to $88.6 million (H1 2017: $103.9m) driven by the adoption of the TIS policy which caused our consolidated joint venture Hutchison Sinopharm to cease recognizing gross sales from certain third-party products and instead earn service fees from such sales in the first half of 2018. Revenue from the Innovation Platform decreased to $13.6 million in the first half of 2018 (H1 2017: $22.7m), reflecting similar levels of service fee payments from our partners as was received in the first half of 2017 but, no milestone payments were received in the first half of 2018 (H1 2017: $5.0m from AstraZeneca and $4.5m from Lilly). It should be noted that Group revenues do not include the revenues of our two large-scale, 50/50 joint ventures in China, SHPL and HBYS, since these are accounted for using the equity method.

In the first half of 2018 our Commercial Platform, which continues to be an important profit and cash source for Chi-Med, grew operating profit by 22% to $31.0 million (H1 2017: $25.3m on an as adjusted (non-GAAP) basis excluding one-time gains of $2.5m) as a result of strong growth in SHPL's coronary artery disease Prescription Drug business, service fees on Seroquel^® and Concor^® and elimination of production capacity constraints on our Consumer Health businesses. The Innovation Platform incurred an operating loss of $53.1 million (H1 2017: -$14.8m) as a result of expansion of practically all aspects of our R&D organization and operations as well as clinical development of our pipeline of eight drug candidates.

Net corporate unallocated expenses, primarily Chi-Med Group overhead and operating costs, declined to $4.9 million (H1 2017: $6.7m) mainly due to higher interest income from short-term investments.

Consequently, Chi-Med Group's operating loss was $27.0 million (H1 2017: operating profit of $6.3m).

The aggregate of interest and income tax expenses of Chi-Med Group, as well as net income attributable to non-controlling interests was $5.7 million (H1 2017: $4.6m) mainly due to higher profit taxes and an increase in the share of net income attributable to a non-controlling interest in the Commercial Platform.

The resulting total Group net loss attributable to Chi-Med was $32.7 million (H1 2017: net income $1.7m).

As a result, Group net loss attributable to Chi-Med in the first half of 2018 was $0.49 per ordinary share / $0.245 per American depositary share ("ADS"), compared to net income attributable to Chi-Med of $0.03 per ordinary share / $0.015 per ADS, in H1 2017.

During the past two years, we have had a high degree of success in proof-of-concept studies on our eight clinical drug candidates, which has naturally resulted in a significant increase in investment. The scale of our late-stage clinical trial programs has expanded significantly, with a total of seven registration studies, either Phase III or Phase II registration intent studies, either underway or completing. We plan for four additional registration studies to start in late 2018/early 2019 as well as to continue early development Phase Ib/II studies in approximately 20 Target Patient Populations ("TPPs").

We have, and will continue to try to partially offset increasing clinical investment with cash generated in our operating activities from dividends paid by our non-consolidated Commercial Platform joint ventures, as well as payments received from AstraZeneca, Lilly, and NSP, our joint venture with Nestlé. In aggregate, in the first half of 2018, these helped offset a meaningful portion of the $66.7 million (H1 2017: $37.5m) in R&D expenses on an as adjusted (non-GAAP) basis.

As of June 30, 2018, we had available cash resources of $416.9 million (December 31, 2017: $479.6m) at the Chi-Med Group level including cash and cash equivalents and short-term investments of $322.5 million (December 31, 2017: $358.3m) and unutilized bank borrowing facilities of $94.4 million (December 31, 2017: $121.3m). In addition, as of June 30, 2018, our non-consolidated joint ventures (SHPL, HBYS and NSP) held $62.5 million (December 31, 2017: $67.0m) in available cash resources.

Outstanding bank loans as of June 30, 2018 amounted to $26.7 million (December 31, 2017: $30.0m) at the Chi-Med Group level, with a weighted average cost of borrowing in the first half of 2018 of 2.33% (year ended December 31, 2017: 1.90%). As of June 30, 2018 and December 31, 2017, our non-consolidated joint ventures had no outstanding bank loans.

In summary, we believe that the cash resources that we currently hold are sufficient to fund all our near-term activities, including the full development of our clinical drug pipeline into 2020.

The Chi-Med pipeline of drug candidates has been created and developed by the in-house R&D operation which was started in 2002. Since then, we have built a large team of about 390 scientists and staff (June 30, 2017: 330) based in China and are operating a fully-integrated drug discovery and development operation covering chemistry, biology, pharmacology, toxicology, chemistry and manufacturing controls for clinical and commercial supply, clinical and regulatory and other functions. Looking ahead, we plan to continue to build and leverage this platform, as we have in the past decade, to produce a stream of novel drug candidates with global potential.

Innovation Platform revenue in the first half of 2018 was $13.6 million (H1 2017: $22.7m) reflecting generally similar levels of service fees and clinical cost reimbursements received from AstraZeneca and Lilly to those received in the first half of last year. Revenue in the first half of 2017 also included milestone payments from AstraZeneca and Lilly for the start of the savolitinib Phase III clinical trial in PRCC ($5.0m) and the submission of the first fruquintinib NDA ($4.5m). We did not receive any milestone payments in the first half of 2018.

In the first half of 2018 we granted options to purchase on over 870,000 ordinary shares to over 40 members, primarily of the Innovation Platform middle management team, an important step to broaden equity participation among the future leaders of the company. The non-cash expense for these grants totaled $20.4 million and will be amortized over four years, with $7.1 million expected to be expensed in 2018.

Net loss attributable to Chi-Med increased to $52.9 million (H1 2017: -$14.8m) mainly from increased R&D expenses of $66.7 million (H1 2017: $37.5m) on an as adjusted (non-GAAP) basis driven by expansion of clinical development activities, the aforementioned organization growth and new share-based incentives, as well as further investment in the expansion of small molecule manufacturing operations.

Since inception, the Innovation Platform has dosed over 4,000 patients/subjects in clinical trials of our drug candidates with over 400 dosed in the first half of 2018 primarily as a result of enrollment in the seven registration studies that we had underway during the period.

In the second quarter of 2018, we commenced operations of Hutchison MediPharma (US) Inc. at our new U.S. offices in Florham Park, New Jersey. While we have been conducting clinical and non-clinical development in North America and Europe for over a decade, the activities conducted by this new U.S. office will support our growth strategy outside of China and significantly broaden and scale our non-Asia clinical development and international operations. As part of this strategy, we recruited two experienced senior personnel, namely the U.S. Chief Medical Officer, and the Head of International Operations. They will support our expansion of clinical development and regulatory activities outside Asia, including initiating and managing Phase II trials of fruquintinib, sulfatinib and HMPL-523 in the U.S. and preparing for the commercial launch of fruquintinib and sulfatinib outside of mainland China, if approved.

Savolitinib is a potential first-in-class inhibitor of c-MET, an enzyme which has been shown to function abnormally in many types of solid tumors. We designed savolitinib to be a potent and highly selective oral inhibitor, which, through chemical structure modification, addresses human metabolite-related renal toxicity, the primary issue that halted development of several other selective c-MET inhibitors. In clinical studies to date, involving over 700 patients, savolitinib has shown promising signs of clinical efficacy in patients with c-MET gene alterations in PRCC, NSCLC, CRC and gastric cancer with an acceptable safety profile. We are currently testing savolitinib in partnership with AstraZeneca in multiple Phase Ib/II studies, both as a monotherapy and in combinations. Two registration studies, one in kidney and one in lung cancer, are underway and several additional studies, that we believe could ultimately serve as registration studies, are expected to start over the next 6-12 months.

Savolitinib—Kidney cancer: High proportion of MET-driven patients. The table below shows a summary of the clinical studies that we have underway for savolitinib in kidney cancer patients.

TPP 1—Enrolling (NCT03091192)—Phase III PRCC savolitinib once daily ("QD") monotherapy (Global)—A global Phase III registration study, the SAVOIR study, of savolitinib versus Sutent^® in c-MET-driven metastatic PRCC patients was initiated in June 2017. The primary endpoint for efficacy in the SAVOIR study is median progression free survival ("PFS"), with secondary endpoints of OS, objective response rate ("ORR"), duration of response ("DoR") and disease control rate ("DCR"). All clinical trial site initiations in six countries were completed early this year, and we expect enrollment to complete around the end of 2019.

The MES is ongoing, whereby archived tissue samples from over 200 PRCC patients are being screened using our companion diagnostic to identify c-MET-driven disease. We expect this global MES to contribute to developing a more comprehensive understanding of the role of c-MET-driven disease in PRCC. Historical medical records from these patients will then be used to determine if c-MET-driven disease is predictive of worse outcome, in terms of PFS and OS, in PRCC patients. If this is proven to be the case, we will consider engaging in discussions regarding Breakthrough Therapy potential with the FDA. We expect to have the full MES data by the end of 2018, and could present it at a major scientific conference in 2019.

TPP 2—Enrolling (NCT02761057)—Phase II study of multiple TKIs in metastatic PRCC (U.S.)—A Phase II study, sponsored by the U.S. National Cancer Institute, and named the PAPMET study, to assess the efficacy of multiple TKIs in metastatic PRCC including Sutent^®; Cabometyx^® (cabozantinib); Xalkori^® (crizotinib) and savolitinib. PAPMET began enrolling patients in 2016, and is expected to enroll about 180 patients in over 70 locations in the U.S. The savolitinib arm of the study is over a third enrolled and is expected to complete enrollment in 2019.

TPP 3, TPP 4 and TPP 5—Enrolling (NCT02819596)—Phase II study of savolitinib monotherapy and in combination with Imfinzi^® (anti-PD-L1) in both PRCC and ccRCC patients (U.K./Spain)—A dose finding study began in 2016, named the CALYPSO study, at St. Bartholomew's Hospital in London, to assess safety/tolerability of savolitinib and Imfinzi^® combination therapy as well as preliminary efficacy of savolitinib as a monotherapy or combination therapy in several c-MET-driven kidney cancer patient populations. During 2016, the dose-finding phase of the CALYPSO study successfully established the combination dose of savolitinib and Imfinzi^® and the study moved onto the Phase II expansion stage in PRCC and ccRCC patients in the U.K. and Spain to further explore efficacy. Patient recruitment moved rapidly in the first half of 2018. Enrollment for PRCC patients is expected to complete in the second half of 2018 and for ccRCC patients in the first half of 2019.

Savolitinib—Lung cancer: We believe this is Savolitinib's largest market opportunity. The table below shows a summary of the clinical studies that we have underway for savolitinib in lung cancer patients.

Tagrisso^® combinations: In 2016, we initiated a global Phase Ib/II expansion study in NSCLC, the TATTON (Part B) study, aiming to recruit sufficient c-MET gene amplified patients, who had progressed after prior treatment with a first/second-generation TKI (e.g. Iressa^®/Tarceva^®), to support a decision on global Phase II/III registration strategy. In this first/second-generation EGFR TKI refractory NSCLC population, we estimate that c-MET gene amplification occurs in 15-20% of patients, while the T790M mutation occurs in approximately 45-70% of patients. TATTON (Part B) also included patients who subsequently developed resistance to third-generation EGFR TKIs (primarily Tagrisso^®). Preliminary data was presented in October 2017 at World Conference on Lung Cancer ("WCLC") (as described below). TATTON (Part B) continued to enroll and further data, including PFS, is expected to be presented at a scientific conference in the future. Other parallel studies, TATTON (Part C) and TATTON (Part D), were initiated in 2017 and will further broaden our data set in the 400mg (Japan only) and 300mg QD dose, respectively, over the balance of 2018 and early 2019. Earlier this year, AstraZeneca decided to progress onto the next stage of development of two separate indications, and planning for each is underway as described below (TPP 7 & TPP 6).

TPP 7—Enrolling (NCT02143466)—Phase Ib/II NSCLC (second- or third-line 3^rd-generation EGFR TKI- (primarily Tagrisso^®) refractory), savolitinib (600mg QD) in combination with Tagrisso^® (Global) —Data presented in June 2017 at ASCO, by Harvard Medical School and Massachusetts General Hospital Cancer Center ("HMS/MGH"), showed that about 30% (7/23 patients) of Tagrisso^® resistant NSCLC patients harbor c-MET gene amplification. This patient population is generally heavily pre-treated and highly complex from a molecular analysis standpoint, with the HMS/MGH study showing that more than half the c-MET gene amplification patients also harbored additional genetic alterations, including but not limited to EGFR gene amplification. At the 2017 WCLC, preliminary TATTON (Part B) study data included 30 evaluable patients previously treated with third-generation T790M-directed EGFR inhibitors, primarily Tagrisso^®. Confirmed partial response ("PRs") were observed in 10/30 (ORR 33%) of these patients, which was as expected given the additional driver genes at work post Tagrisso^® monotherapy failure. We believe that the savolitinib/Tagrisso^® combination is an important treatment option for these late-stage c-MET gene amplified patients who have no remaining targeted treatment alternatives. Moreover, the FDA and the European Commission approved Tagrisso^® for first-line treatment of

EGFR-mutation NSCLC in April and June 2018, respectively, and as such the need for treatment following Tagrisso^® is expected to increase.

Encouraged by the above-mentioned data and recent approvals of Tagrisso^®, AstraZeneca has decided to prioritize proceeding with development of savolitinib in NSCLC for patients that are refractory to third-generation EGFR TKI by the end of 2018. This will start out as a single-arm, Phase II study for savolitinib (600mg, 300mg if <55kg QD) and Tagrisso^® (80mg QD).

TPP 6—Enrolling (NCT02143466)—Phase Ib/II expansion NSCLC (second-line 1^st/2^nd-generation EGFR TKI-refractory), savolitinib in combination with Tagrisso^® (Global)—At the 2017 WCLC, preliminary TATTON (Part B) study data included 34 evaluable patients who showed confirmed PRs in 14/23 (ORR 61%) of T790M mutation negative patients, as well as confirmed PRs in 6/11 (55% ORR) of T790M mutation positive patients.

Planning is now underway for a global randomized controlled study of the savolitinib plus Tagrisso^® combination in this TPP 6, first/second-generation EGFR TKI-refractory (Iressa^®/Tarceva^®), c-MET-driven, T790M mutation-negative NSCLC patients. This will also start out as a Phase II study and is currently targeted to start in H1 2019.

TPP 8—Completed (NCT02374645)—Phase II NSCLC (second-line), EGFR TKI-refractory, savolitinib in combination with Iressa^® (China)—We continue to discuss how this combination can be further developed.

TPP 9 and TPP 10—Enrollment Completed and Enrolling (NCT01985555 / NCT02897479)—Phase II c-MET-driven NSCLC, savolitinib monotherapy (China) —Phase II studies of savolitinib are ongoing in NSCLC focusing on patients with c-MET-driven disease. These are NSCLC patients with MET Exon 14 mutation/deletion who have failed prior systemic therapy, or are unwilling or unable to receive chemotherapy. Following recent regulatory dialogue and a subsequent protocol amendment, we expect that this study, if successful, would be sufficient to support an NDA submission in China. Preliminary data in these TPPs may be presented at a major scientific conference in 2019.

Savolitinib—Gastric cancer: multiple Phase II studies underway in Asia in c-MET-driven patients.

Phase II gastric cancer studies are ongoing in China as well as the VIKTORY umbrella study, being run at the Samsung Medical Center in South Korea, in which savolitinib is represented in three out of the twelve treatment arms. As at the latest report in 2017, a total of over 850 gastric cancer patients had been screened in these studies and those patients with confirmed c-MET-driven disease are being treated with either savolitinib monotherapy or savolitinib in combination with Taxotere^®. Presentations of preliminary data from these studies were made in 2017 at the annual meetings of the Chinese Society of Clinical Oncology ("CSCO") (China Phase II, 441 patients screened) and ASCO (VIKTORY Phase II, 438 patients screened), with about 5.1% of patients determined to have c-MET gene amplification. The table below shows a summary of the clinical studies that we have underway for savolitinib in gastric cancer patients.

TPP 11—Enrolling (South Korea (NCT02449551) / China (NCT01985555))—Phase II gastric cancer, savolitinib monotherapy, patients with c-MET gene amplification (South Korea/China)—Preliminary results were presented at the CSCO 2017 conference for the efficacy evaluable c-MET gene amplified patients in China. This China study concluded that savolitinib monotherapy demonstrated promising anti-tumor efficacy in gastric cancer patients with c-MET gene amplification, and the potential benefit to these patients clearly warrants further exploration, including continuing enrollment for a Phase II study in China. The VIKTORY Phase II study is ongoing in c-MET gene amplified patients in South Korea, and preliminary data may be presented at a major scientific conference in the second half of 2018 or in 2019.

TPP 12 and TPP 13—Enrolling (NCT02447380 / NCT02447406)—Phase II studies of savolitinib in combination with Taxotere^® in c-MET over-expression or c-MET gene amplification gastric cancer (South Korea)—Phase II studies are underway to assess safety/tolerability of savolitinib and Taxotere^® combination as well as preliminary efficacy of the combination therapy in both c-MET gene amplified patients and, the approximately 40% of gastric cancer patients who harbor c-MET over-expression. The VIKTORY Phase II is ongoing in South Korea in TPP 12 and 13, with preliminary data may be presented at a major scientific conference in the second half of 2018 or in 2019.

Savolitinib—Prostate cancer: The table below shows a summary of the clinical study that we have underway for savolitinib in prostate cancer patients.

TPP 14—Enrolling (NCT03385655)—Phase II study in patients with metastatic Castration-Resistant Prostate Cancer ("mCRPC") (Canada)—study sponsored by the Canadian Cancer Trials Group is designed to determine the effect of savolitinib on prostate-specific antigen ("PSA") decline and time to PSA progression, ORR as determined by RECIST 1.1 criteria, the safety and toxicity profile of savolitinib in mCRPC patients, as well as any potential predictive and prognostic factors. The umbrella study targets to enroll around 500 patients into six treatment arms based on molecular status, with one treatment arm being patients with aberrant c-MET activation who will receive savolitinib. High levels of c-MET over-expression can be prevalent in prostate cancer patients.

Fruquintinib is a highly selective and potent oral inhibitor of VEGFR 1/2/3 that was designed to be a global best-in-class VEGFR inhibitor for many types of solid tumors. Fruquintinib's unique kinase selectivity has been shown to reduce off-target toxicity thereby allowing for better target coverage, as well as possible use in combination with other agents such as chemotherapies, targeted therapies and immunotherapies. We believe these are points of meaningful differentiation compared to other approved small molecule VEGFR inhibitors, such as Sutent^®, Nexavar^® (sorafenib) and Stivarga^®, and can potentially significantly expand the use and global market potential of fruquintinib.

We believe that fruquintinib is the first home-grown, China-discovered and developed drug candidate in a mainstream oncology indication to succeed in a pivotal Phase III registration trial. There are three pivotal Phase III trials (the FRESCO, FALUCA and FRUTIGA studies) currently underway or completing in China. Our first ever NDA in China for third-line CRC (the FRESCO study) is near the end of the approval application process. We have also completed enrollment in third-line NSCLC (the FALUCA study) and are enrolling patients in a study in combination with Taxol^® in second-line gastric cancer (the FRUTIGA study). Furthermore, a Phase II study in combination with Iressa^® in first-line EGFR activating mutation NSCLC is ongoing, following encouraging preliminary results presented at the 2017 WCLC. We also expect a Phase I study of fruquintinib in the U.S. to complete by the end of 2018, which will represent

the first step in the development of fruquintinib outside China. In China, fruquintinib is jointly developed with Lilly, our commercial partner. The table below shows a summary of the clinical studies that we have underway for fruquintinib.

TPP 15—NDA submitted June 2017 (NCT02314819)—Phase III study in CRC (third-line), fruquintinib monotherapy (China)—Since completing submission of the NDA to the China National Drug Administration ("CNDA", formerly the China Food and Drug Administration) in June 2017, we have engaged the CNDA's Center for Drug Evaluation to conduct reviews in the areas of pharmacology and toxicity, clinical data and statistical analysis, and chemistry, manufacturing and control of standards and process. We have also facilitated the conduct of clinical site visits including Good Clinical Practice and Good Laboratory Practice inspections, and the pre-approval inspections ("PAIs") for our active pharmaceutical ingredient contract manufacturer as well as the PAI and Good Manufacturing Practice ("GMP") certification process for our Suzhou formulation facility. We hope to receive an approval from the CNDA on our NDA in the second half of 2018.

Following the initial presentation of FRESCO, a pivotal Phase III study in 416 patients with locally advanced or metastatic CRC disease that progressed following at least two prior systemic chemotherapies, at the 2017 ASCO annual meeting, two further analyses were subsequently presented at the 2018 ASCO annual meeting. Firstly, the results of a subgroup analysis by prior anti-VEGF or anti-EGFR target therapy in FRESCO showed that fruquintinib had clinically meaningful benefits in third-line metastatic CRC patients regardless of PTT without observed cumulative toxicity. This subgroup analysis result is consistent with the previously reported FRESCO intent-to-treatment population result. Secondly, an ad-hoc analysis aiming to compare the quality-adjusted survival between the two arms of the FRESCO study using Q-TWiST showed that the relative improvement of Q-TWiST observed represents a clinically important quality-of-life benefit for metastatic CRC patients.

In addition, in June 2018, the JAMA published the full results of the FRESCO study. We believe that this is the first time that the JAMA has ever published novel oncology therapy results from China, a testament to the quality of the FRESCO study design, execution, and result.

TPP 16—Enrollment complete (NCT02691299)—Phase III study of fruquintinib monotherapy in third-line NSCLC (China)—Following a positive Phase II study comparing fruquintinib with placebo in advanced non-squamous NSCLC patients who have failed two prior systemic chemotherapies, we initiated a Phase III registration study, the FALUCA study, in December 2015. Results of the Phase II study were presented at the 2016 WCLC and have been published in the Journal of Clinical Oncology. In February 2018, we completed enrollment of the FALUCA study in China, in which a total of 527 patients were randomized at a 2:1 ratio to receive either fruquintinib or placebo plus best supportive care. The primary endpoint for the FALUCA study is OS, with secondary endpoints including PFS, ORR, DCR and DoR. We expect to reach median OS endpoint maturity and report top-line results in late 2018.

TPP 17—Enrollment complete (NCT02976116)—Phase II study of fruquintinib in combination with Iressa^® in first-line NSCLC (China)—In early 2017, we initiated a multi-center, single-arm, open-label, dose-finding Phase II study of fruquintinib in combination with Iressa^® in the first-line setting for patients with advanced or metastatic NSCLC with EGFR activating mutations. We have enrolled about 50 patients in this study with the objective to evaluate the safety and tolerability as well as efficacy of the combination

therapy. Preliminary data was presented at the 2017 WCLC, showing an encouraging efficacy and safety profile.

Fruquintinib's unique safety and tolerability profile, resulting from its high kinase selectivity, combined with better flexibility to manage treatment emergent toxicities due to its shorter half-life than monoclonal antibody anti-angiogenesis therapies, makes it a very high potential combination partner for EGFR-TKIs.

TPP 18—Enrolling (NCT03251378)—Phase I fruquintinib monotherapy in advanced solid tumors (U.S.)—In December 2017, we initiated a multi-center, open-label, Phase I clinical study to evaluate the safety, tolerability and pharmacokinetics ("PK") of fruquintinib in U.S. patients with solid tumors. Upon completion, likely at the end of 2018, our intention is to begin exploring multiple innovative combination studies of fruquintinib and other TKIs, chemotherapy and immunotherapy agents in the U.S.

Recent innovations in solid tumor drugs have focused on targeted therapies and immunotherapies which, as monotherapies, have both delivered improved outcomes for patients. Our proof-of-concept studies have already demonstrated the benefits of TKI combinations with other TKIs or with chemotherapy, and immunotherapy combinations will also be included. As unique next-generation anti-angiogenesis VEGFR TKIs, fruquintinib (with its uniquely selective profile) and sulfatinib (with its inhibition of tumor-associated macrophages, facilitating PD-1 induced immune response) represent ideal candidates for combination with immunotherapy agents such as PD-1/L1 inhibitors to extend the duration of these benefits and expand them to more patients. This hypothesis was recently demonstrated at this year's ASCO annual meeting relating to the combination of Inlyta^® (axitinib) and Keytruda^® (pembrolizumab) in first-line ccRCC in 52 patients, which yielded an ORR of 73% vs. 34% and 38% for Inlyta^® or Keytruda^® monotherapy, respectively.

TPP 19—Enrolling (NCT03223376)—Phase III study of fruquintinib in combination with Taxol^® in gastric cancer (second-line) (China)—In October 2017, we initiated the FRUTIGA study, a randomized, double-blind, Phase III study to evaluate the efficacy and safety of fruquintinib combined with Taxol^® compared with Taxol^® monotherapy for second-line treatment of advanced gastric or gastroesophageal junction adenocarcinoma, in patients who had failed first-line standard 5-flourouracil-based chemotherapy. A total of over 500 patients are expected to be enrolled into the FRUTIGA study at a 1:1 ratio. The primary endpoint is OS, with secondary endpoints including PFS, ORR, DCR and quality-of-life score. Biomarkers related to the anti-tumor activity of fruquintinib will also be explored. We intend to conduct an interim analysis of the FRUTIGA study for futility, sometime during mid-2019.

Sulfatinib is an oral drug candidate with a unique angio-immuno kinase profile which provides both effects on anti-angiogenesis and effects on enhancing the body's immune system, specifically T-cells. In addition to suppressing angiogenesis through inhibiting VEGFR and FGFR1, sulfatinib is a potent inhibitor of CSF-1R, a signaling pathway involved in blocking the activation of tumor-associated macrophages. Sulfatinib is the first oncology candidate that we have taken through proof-of-concept in China and subsequently started clinical development in the U.S. We are currently conducting studies in six TPPs on

sulfatinib and retain all rights to sulfatinib worldwide. A summary of these clinical studies is shown in the table below.

TPP 20—Enrolling (NCT02589821)—Phase III in pancreatic NET patients (China)—In 2016, we initiated the SANET-p study, which is a pivotal Phase III study in patients with low- or intermediate-grade, advanced pancreatic NET. Patients are randomized in a 2:1 ratio to receive either sulfatinib or placebo, on a 28-day treatment cycle. The primary endpoint is PFS, with secondary endpoints including ORR, DCR, time to response, DoR, safety and tolerability. We expect to complete enrollment in 2019 and present top-line results thereafter.

TPP 21—Enrolling (NCT02588170)—Phase III in non-pancreatic NET patients (China)—In December 2015, we initiated the SANET-ep study, which is a pivotal Phase III study in patients with low or intermediate grade advanced non-pancreatic NET. Patients are randomized at a 2:1 ratio to receive either sulfatinib or placebo, on a 28-day treatment cycle. The primary endpoint is PFS, with secondary endpoints including ORR, DCR, time to response, DoR, safety and tolerability. We expect to complete enrollment in 2019 and present top-line results thereafter.

TPP 22—Enrolling (NCT02549937)—Phase Ib/II in pancreatic NET and BTC patients (U.S.)—A Phase I dose escalation study in advanced solid tumor patients in the U.S. completed at the end of the first half of 2018, having confirmed the 300mg QD recommended Phase II dose. Earlier in July 2018, we initiated a U.S. multi-arm Phase Ib/II study to explore efficacy and safety in both pancreatic NET and BTC patients.

TPP 23 and TPP 24—Enrollment complete (NCT02614495)—Phase II study in recurrent/refractory thyroid cancer patients (China)—In 2016, we began an open-label, Phase II proof-of-concept study in patients with recurrent/refractory medullary thyroid cancer ("MTC") or radioactive iodine ("RAI")-refractory differentiated thyroid cancer ("DTC") in China where there are few safe and effective treatment options. In June 2017, we presented preliminary Phase II data at ASCO 2017 conference showing that at the time of data cut-off, a total of 18 patients had been enrolled, and treated with sulfatinib, with preliminary data showing that confirmed PRs were reported in 3/10 (30.0% ORR) RAI-refractory DTC patients and 1/6 (16.7% ORR) MTC patients, and all other patients were reported as stable disease.

TPP 25—Enrolling (NCT02966821)—Phase II study in chemotherapy refractory BTC patients (China)—In early 2017, we began a Phase II proof-of-concept study in patients with BTC, a heterogeneous group of rare malignancies arising from the biliary tract epithelia and the gallbladder. We see a major unmet medical need for patients who have progressed while on chemotherapy, and believe that sulfatinib may offer a new targeted treatment option in this tumor type. Planning for a Phase III pivotal study in China in this TPP is now underway.

A significant portion of NSCLC patients, estimated at approximately 10-15%, have developed brain metastasis by the time of first diagnosis and eventually approximately 50% of NSCLC patients are estimated to develop brain metastasis. Patients with brain metastasis have a dismal prognosis and a poor quality of life with limited treatment options. Epitinib is a potent and highly selective oral EGFR inhibitor

which has demonstrated brain penetration and efficacy in both pre-clinical and clinical studies. EGFR inhibitors have revolutionized the treatment of NSCLC with EGFR activating mutations. However, approved EGFR inhibitors such as Iressa^® and Tarceva^® cannot penetrate the blood-brain barrier effectively, leaving the majority of patients with brain metastasis without an effective targeted therapy. We currently retain all rights to epitinib worldwide. The table below shows a summary of the clinical studies that we have underway for epitinib.

TPP 26—Enrolling (NCT02590952)—Phase Ib epitinib monotherapy in NSCLC patients with activating EGFR-mutations and brain metastasis (China)—In December 2016 at the WCLC, we presented encouraging efficacy data from an open label, multi-center Phase I dose expansion study. For EGFR TKI naïve patients treated with epitinib 160mg QD dose, ORR was in the range of 60-70% (including confirmed and unconfirmed PRs), with a tolerable safety profile. During the first half of 2018, we continued to enroll patients in this Phase Ib study and, as a result of our recent dialogue with regulators, are planning to initiate a Phase III study in late 2018.

TPP 27—Enrolling (NCT03231501)—Phase Ib/II study in glioblastoma —Glioblastoma is a primary brain cancer that harbors high levels of EGFR gene amplification. In March 2018, we initiated a Phase Ib/II study multi-center, single-arm, open-label study to evaluate the efficacy and safety of epitinib as a monotherapy in patients with EGFR gene amplified, histologically confirmed glioblastoma. The primary endpoint is ORR.

Theliatinib is a novel molecule EGFR inhibitor under investigation for the treatment of solid tumors. Tumors with wild-type EGFR activation, for instance, through gene amplification or protein over-expression, are less sensitive to current EGFR TKIs, Iressa^® and Tarceva^®, due to their sub-optimal binding affinity. Theliatinib has been designed with strong affinity to the wild-type EGFR kinase and has been shown to be five to ten times more potent than Tarceva^®. Consequently, we believe that theliatinib could benefit patients with tumor-types with a high incidence of wild-type EGFR activation. This is notable in certain cancer types such as esophageal cancer, where 8-30% of patients harbors EGFR gene amplification and 30-90% EGFR over-expression. We currently retain all rights to theliatinib worldwide. The table below shows a summary of the clinical studies that we have underway for theliatinib.

TPP 28—Completed (NCT02601274)—Phase I study of theliatinib monotherapy in solid tumors (China)—At the 2017 CSCO conference, we presented results from the Phase I study of the safety and preliminary anti-tumor activity of theliatinib. Results showed that doses up to 500mg QD were determined to be safe and well-tolerated, with no dose limiting toxicities or maximum tolerated dose established. The study concluded that further development of theliatinib 400mg QD amongst esophageal cancer patients with EGFR over-expression was warranted (TPP 29).

TPP 29—Enrolling (NCT02601274)—Phase Ib expansion theliatinib monotherapy in esophageal cancer (China)—In early 2017, we began a Phase Ib proof-of-concept expansion study of theliatinib in esophageal cancer patients with EGFR protein over-expression or gene amplification. This study is now in the process of expanding through the opening of additional clinical sites in China.

HMPL-523 is a potential best-in-class oral inhibitor targeting Syk, a key protein involved in B-cell signaling. Modulation of the B-cell signaling system has proven to have significant potential for the treatment of certain chronic diseases in immunology, such as rheumatoid arthritis, immune thrombocytopenia (ITP) or lupus, as well as hematological cancers where it is a potential first-in-class compound. We currently retain all rights to HMPL-523 worldwide. The table below shows a summary of the clinical studies that we have underway for HMPL-523.

TPP 30 and TPP 31—Completed (NCT02105129)—Phase I study (healthy volunteers) (Australia/China)—We believe HMPL-523, as an oral drug candidate, has advantages over intravenous monoclonal antibody immune modulators in rheumatoid arthritis in that small molecule compounds can be taken orally and have shorter half-lives, thereby reducing the risk of infections from sustained suppression of the immune system. The Phase I dose escalation study showed HMPL-523 exhibited a tolerable safety profile, with data presented in full at the 2016 American College of Rheumatology conference. Off-target toxicities such as diarrhea and hypertension, seen with the first-generation Syk inhibitor fostamatinib, were not observed. In addition to tolerable safety, this Phase I dose escalation study evaluated the PK and pharmacodynamic ("PD") profile of HMPL-523.

TPP 32 and TPP 33—Enrolling (NCT02503033 / NCT02857998)—Phase I study of HMPL-523 in hematological cancers (Australia/China)—In early 2016, we initiated a Phase I dose escalation study of HMPL-523 in Australia in hematological cancer patients and have completed seven dose cohorts. China Phase I began in early 2017 and completed five dose cohorts. Recommended Phase II doses have been determined and dose expansion studies have initiated in both Australia and China. Since early 2018, we have been increasing the number of active clinical sites, now totaling 13, in Australia and China to support a large dose expansion program in a broad range of hematological cancers. These include, chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, follicular lymphoma and diffuse large B-cell lymphoma. We target to present dose escalation results, including preliminary proof-of-concept data, at a major scientific conference later in 2018 or in 2019. Our U.S. IND application for HMPL-523 was cleared by the FDA at the end of June 2018 and we are now planning Phase II development.

HMPL-689 is a novel, potential best-in-class, highly selective and potent small molecule inhibitor targeting the isoform PI3Kd, a key component in the B-cell receptor signaling pathway. We have designed HMPL-689 with superior PI3Kd isoform selectivity. HMPL-689's PK properties have been found to be favorable with good oral absorption, moderate tissue distribution and low clearance in preclinical PK studies. We also expect that HMPL-689 will have low risk of drug accumulation and drug-to-drug interaction. We currently retain all rights to HMPL-689 worldwide. The table below shows a summary of the clinical studies that we have underway for HMPL-689.

TPP 34 and TPP 35—Enrolling (NCT02631642 / NCT03128164)—Phase I dose escalation (Australia/China)—In 2016, we completed a Phase I dose escalation study in Australia in healthy adult volunteers to evaluate HMPL-689's PK and safety profile following single oral dosing. Results were as expected with linear PK properties and tolerable safety profile. We subsequently initiated a Phase I dose escalation and expansion study in patients with hematologic malignancies in China in August 2017.

HMPL-453 is a novel, potentially first-in-class, highly selective and potent small molecule inhibitor that targets FGFR 1/2/3, a sub-family of receptor tyrosine kinases. Aberrant FGFR signaling has been found to be a driving force in tumor growth, promotion of angiogenesis and resistance to anti-tumor therapies. To date, there are no approved therapies specifically targeting the FGFR signaling pathway. In pre-clinical studies, HMPL-453 demonstrated excellent kinase selectivity as well as strong anti-tumor potency. Abnormal FGFR gene alterations are believed to be the drivers of tumor cell proliferation in several solid tumor settings. We currently retain all rights to HMPL-453 worldwide. The table below shows a summary of the clinical studies that we have underway for HMPL-453.

TPP 36 and TPP 37—Enrolling (NCT02966171 / NCT03160833)—Phase I dose escalation (Australia/China)—In early 2017, we initiated first-in-human Phase I dose escalation studies in both Australia and China to evaluate safety, tolerability, PK, PD and preliminary anti-tumor activity in patients with advanced or metastatic solid tumors. In July 2018 we discontinued the Australian Phase I study due to the emergence of certain serious, though non-life threatening, FGFR target related toxicities. The China Phase I continues, with additional measures designed to minimize risk to patients, due to the overall greater tolerance and lower toxicities experienced in Chinese patients.

The table below shows the clinical study that we have underway for HMPL004-6599.

TPP 38—Enrolling (NCT03597971)—Phase I dose escalation (Australia) —HMPL004-6599 is a proprietary botanical drug for the treatment of inflammatory bowel disease, which we are developing through NSP, our 50/50 joint venture with Nestlé. We initiated Phase I clinical studies in Australia in April 2018 and completed the single ascending dose stage. Phase II enabling non-clinical studies are being initiated. HMPL004-6599 is an enriched/purified re-formulation of HMPL-004, our drug candidate that reported positive Phase II results in ulcerative colitis in 2010, but later proved futile in an interim analysis of the subsequent Phase III study in 2014.

The Commercial Platform, which has been built over the past 17 years, is focused on two business areas. First is our core Prescription Drugs business, a higher-margin/profit business operated through our joint ventures SHPL and Hutchison Sinopharm, in which we nominate management and run the day-to-day operations. Our Prescription Drugs business is a platform that we plan to use to launch our Innovation Platform drugs once approved in China. Second is our Consumer Health business, which is a profitable

and cash flow generating business selling primarily market-leading, household-name OTC pharmaceutical products through our non-consolidated joint venture HBYS.

In the first half of 2018, the Commercial Platform delivered strong net income growth despite a change in the way we recognize certain sales resulting from the implementation of the TIS and the divestment of a non-core OTC logistics business. Consolidated sales of our Commercial Platform's subsidiaries decreased by 15% to $88.6 million (H1 2017: $103.9m) as TIS caused us to shift from a gross sales revenue model to a service fee revenue model with respect to sales of certain third-party products. The sales of our Commercial Platform's non-consolidated joint ventures, SHPL and HBYS, grew by 21% to $271.7 million (H1 2017: $224.2m excluding divested operations). These resulted in adjusted (non-GAAP) consolidated net income attributable to Chi-Med from our Commercial Platform up 19% to $26.9 million (H1 2017: $22.7m) when one-time gains were excluded (H1 2017: $2.5m, R&D-related subsidies to SHPL).

In the first half of 2018, sales of our Prescription Drugs subsidiaries decreased as expected by 21% to $68.0 million (H1 2017: $85.8m) as a result of the implementation of TIS. Sales of our non-consolidated Prescription Drugs joint venture (SHPL) grew by 18% to $152.7 million (H1 2017: $129.7m). The consolidated (non-GAAP) net income attributable to Chi-Med from our Prescription Drugs business was up 23% to $20.8 million (H1 2017: $16.9m, excluding one-time gains from R&D-related subsidies to SHPL). The Prescription Drugs business represented 77% of our overall Commercial Platform net income in the first half of 2018.

SHPL: Our own-brand Prescription Drugs business, operated through our non-consolidated joint venture SHPL, is a well-established and stable-growth business. In the first half of 2018, SHPL delivered sales growth of 18% at $152.7 million (H1 2017: $129.7m) as a result of both volume and price growth on SXBX pill.

SXBX pill: SHPL's main product is SXBX pill, an oral vasodilator and pro-angiogenesis prescription therapy approved to treat coronary artery disease, which includes stable/unstable angina, myocardial infarction and sudden cardiac death. There are over one million deaths due to coronary artery disease per year in China, with this number set to rise due to an aging population with high levels of smoking (34% of adults), increasing levels of obesity (28% of adults are overweight) and hypertension (26% of adults). SXBX pill is the third largest botanical prescription drug in this indication in China, with a market share of 15% nationally and 47% in Shanghai. Sales of SXBX pill have grown more than twenty-fold since 2001 due to continued geographical expansion of sales coverage, including 18% to $129.8 million in the first half of 2018 (H1 2017: $110.4m).

SXBX pill is protected by a formulation patent that expires in 2029 and is one of less than two dozen proprietary prescription drugs represented on China's National Essential Medicines List, which means that all Chinese state-owned health care institutions are required to carry the drug. SXBX pill is a low-cost drug, fully reimbursed in all provinces in China, listed on China's Low Price Drug List with a 2017 average daily cost of RMB4.00 (2016: RMB3.30), or approximately $0.60. In the coming years, we anticipate stable growth in sales and profit for SXBX pill given the strength of its proposition and the expected expansion of the coronary artery disease market in China driven by an aging population and trends in diet leading to increasing obesity.

The SHPL operation is large-scale in both the commercial and manufacturing areas. The commercial team now has about 2,400 medical sales representatives which allows for the promotion and scientific detailing of our prescription drug products not just in hospitals in provincial capitals and medium-sized cities, but also in the majority of county-level hospitals in China. SHPL's new, GMP-certified factory located 40

kilometers south of Shanghai in Fengpu district holds 74 drug product manufacturing licenses and is operated by about 550 manufacturing staff. This new factory, opened in 2017, has approximately tripled SHPL's capacity and therefore positions us well for continued long-term growth.

Concor^®: Concor^® (Bisoprolol tablets) is a cardiac beta1-receptor blocker, relieving hypertension and reducing high blood pressure. Concor^® is the number two beta-blocker in China with an approximately 18% national market share in China's beta-blocker drug market and 70% of China's generic bisoprolol market. SHPL is now the exclusive marketing agent in six provinces, markets that contain over 360 million people. We have created synergy with SHPL's existing cardiovascular medical sales team by detailing Concor^® alongside SXBX pill. In the first half of 2018, we grew Concor^® sales by 25%, resulting in service fees of $2.2 million (H1 2017: $1.1m). We expect growth in these fees will continue to be driven by cardiovascular market expansion.

Hutchison Sinopharm: Our Prescription Drugs commercial services business, which is operated through Hutchison Sinopharm, focuses on providing logistics services to, and distributing and marketing prescription drugs manufactured by, third-party pharmaceutical companies in China. In the first half of 2018, Hutchison Sinopharm sales decreased 21% to $68.0 million (H1 2017: $85.8m) as a result of the TIS implementation, as described below.

Regulatory reform in the China pharmaceutical distribution system—The new TIS, a mandatory government policy, has now been rolled-out across China. In principle, the purpose of the TIS is to restrict the number of layers in the drug distribution system in China and to improve transparency, compliant business conduct, and efficiency and thereby lower the cost of drugs. The impact to us is that, starting in October 2017, the Seroquel^® sales model, in which our consolidated revenues historically reflected total gross sales of Seroquel^®, shifted to a fee-for-service model similar to that used with respect to Concor^®. This change reduced the top-line revenues that Hutchison Sinopharm records from sales of Seroquel^® as well as several of our other third-party products. Importantly, however, this drop in reported sales has had no impact on profitability, the service fees paid to Hutchison Sinopharm, or our commercial team operations and expansion plans.

Seroquel^®: Seroquel^® (quetiapine tablets) is an anti-psychotic therapy approved for bi-polar disorder and schizophrenia, conditions that are under-diagnosed in China. Seroquel^® holds a 5.6% market share in China's approximately $0.9 billion atypical anti-psychotic prescription drug market, and 45% of China's generic quetiapine market, primarily as a result of being the first-mover and original patent holder on quetiapine. Seroquel^® is the only brand in China to have an extended release (XR) formulation, which in 2017 was included on the National Drug Reimbursement List (NDRL), thereby providing us with major competitive advantage over quetiapine generics.

Hutchison Sinopharm is the exclusive marketing agent for Seroquel^® tablets in China and operates through a team of about 110 dedicated medical sales representatives. As stated throughout, the new TIS has had no effect on profitability, with service fees paid to Hutchison Sinopharm for marketing Seroquel^® during the first half of 2018 increasing 75% to $9.6 million (H1 2017: $5.5m).

In June 2018, AstraZeneca sold and licensed rights to Seroquel^® to Luye Pharma Group, Ltd., including the transfer of contracts entered into by AstraZeneca with third parties. The terms of our agreement with AstraZeneca were assigned to Luye Pharma Hong Kong Ltd. and remain unchanged following this transaction, and this transaction has not affected our 2018 financial guidance.

Subject to Hutchison Sinopharm's continued performance of marketing services, and delivery of approximately 22% in-market sales growth in 2018 and 15% per year thereafter, we will continue to retain exclusive commercial rights to Seroquel^® in China until 2025. Growth in Seroquel in-market sales during

the first half of 2018 was 36% due to overall strong execution. We expect Hutchison Sinopharm to have a reasonable chance to meet these annual Seroquel^® sales targets over the next several years, although such sales are subject to a number of factors, some of which are beyond our control, including potential changes in government pricing policies in China.

During the first half of 2018, sales of our Consumer Health subsidiaries increased by 14% to $20.6 million (H1 2017: $18.1m) and sales of our non-consolidated Consumer Health joint venture (HBYS) were $119.0 million, a 26% increase (H1 2017: $94.4m on an as adjusted (non-GAAP) basis, excluding divested operation sales of $29.0m). Consolidated net income attributable to Chi-Med from our Consumer Health business grew by 7% to $6.1 million (H1 2017: $5.8m). The Consumer Health business represented 23% of our overall Commercial Platform net income in the first half of 2018.

HBYS: Our OTC business operated through our non-consolidated joint venture, HBYS, focuses on the manufacture, marketing and distribution of OTC pharmaceutical products. Its Bai Yun Shan brand is a market-leading, household name, established over 40 years ago, and is known by the majority of Chinese consumers. In addition to about 1,000 manufacturing staff in Guangdong and Anhui and 189 drug product licenses, HBYS has a commercial team of about 1,000 sales staff that covers the national retail pharmacy channel in China. The increased available production capacity as detailed below, and a decline in the prices of certain key raw materials, resulted in the above strong revenue and net income growth in the first half of 2018.

New Bozhou factory: In August 2017, HBYS transferred the majority of production to our new GMP-certified low-cost factory in Bozhou, Anhui. Capacity until this point had been constrained and production had to be supplemented by third-party contract manufacturers. These production capacity constraints were eliminated in the second half of 2017 once the Bozhou factory began production.

Fu Fang Dan Shen ("FFDS") tablets and Banlangen granules: FFDS tablets (angina) and Banlangen granules (anti-viral cold/flu), the two main products of HBYS, are generic OTC drugs with leading national market share in China of 38% (2016: 32%) and 53% (2016: 51%), respectively. The first half of 2018 saw the combined sales of these products increased by 10% to $70.7 million (H1 2017: $64.3m). This was largely due to the reversal of several headwinds affecting Banlangen during the same period in 2017. Banlangen sales grew 34% to $37.9 million in the first half of 2018 due to a moderate to severe flu season and the elimination of manufacturing capacity constraints. This increase was offset in part by a decline in sales of FFDS which fell 9% to $32.8 million as a result of price increases and a reduction in distribution channel inventory ahead of the approval and label expansion of FFDS for use in certain early-stage dementia indications, which is expected in the second half of 2018.

Nanyang Baiyunshan Hutchison Whampoa Guanbao Pharmaceutical Company Limited ("Guanbao") divestment: In September 2017, HBYS divested its 60% shareholding in Guanbao for a consideration approximately equal to its carrying value. Guanbao was a Good Supply Practice distribution company which had been established via a joint venture in 2012. This low margin, primarily third-party OTC logistics business, with operations limited mainly to Henan province, had proven to be a business with no strategic value to Chi-Med. Sales reported under HBYS for Guanbao were nil in the first half of 2018 (H1 2017: $29.0m).

HBYS property update: HBYS's vacant Plot 2 (26,700 sqm.) in Guangzhou has been listed for sale as part of the Guangzhou municipal government's urban redevelopment scheme plan since 2016. The date of this public auction will be determined by the Guangzhou government, while we are actively working to facilitate the process, external factors have to-date hampered progress. Land prices however continue to rise in Guangzhou, and based on precedent land transactions in the vicinity, we expect the auction value for Plot 2 to be well over $100 million of which 40 to 50% would be paid to HBYS as compensation for return of the land use rights. In addition, the move away from HBYS's larger Plot 1 (59,400 sqm.) will be contingent on how the Bozhou factory develops, but, when auctioned, we anticipate that based on recent precedent land transactions, Plot 1 could bring HBYS compensation per square meter comparable to Plot 2.

Hutchison Healthcare Limited ("HHL") and Hutchison Hain Organic Holdings Limited ("HHOH"): HHL, HHOH and other minor entities are subsidiaries involved in the commercialization of health-related consumer products. Sales of such products in the first half of 2018 grew by 14% to $20.6 million (H1 2017: $18.1m) driven in part by growth of the Zhi Ling Tong^® and Earth's Best^® infant nutrition products.

The profits of the Commercial Platform continue to pass on to the Chi-Med Group through dividend payments primarily from our non-consolidated joint ventures, SHPL and HBYS. Dividends of $23.5 million (H1 2017: $42.6m) were paid from these joint ventures to the Chi-Med Group level in the first half of 2018. Dividends in the first half of 2017 were unusually high as the proceeds of one-time land compensation from SHPL were paid out. Net income from SHPL and HBYS have totaled over $500 million since 2005, of which $355 million has been paid in dividends to Chi-Med and its partners, with the balance retained by the joint ventures as cash or used primarily to fund factory upgrades and expansion. As of June 30, 2018, SHPL and HBYS held in aggregate $41.9 million in cash and cash equivalents, with no outstanding bank borrowings.

In addition to financial information prepared in accordance with U.S. GAAP, this announcement also contains certain non-GAAP financial measures based on management's view of performance including:

Management uses such measures internally for planning and forecasting purposes and to measure the Chi-Med Group's overall performance. We believe these adjusted financial measures provide useful and meaningful information to us and investors because they enhance investors' understanding of the continuing operating performance of our business and facilitate the comparison of performance between past and future periods. These adjusted financial measures are non-GAAP measures and should be considered in addition to, but not as a substitute for, the information prepared in accordance with U.S. GAAP. Other companies may define these measures in different ways. The following items are excluded from adjusted financial results:

Adjusted R&D expenses: We exclude the impact of the revenue received from external customers of our Innovation Platform, which is reinvested into our clinical trials, to derive our adjusted R&D expense. Revenue received from external customers of our Innovation Platform consists of milestone and other payments from our collaboration partners. The variability of such payments makes the identification of trends in our ongoing R&D activities more difficult. We believe the presentation of adjusted R&D expenses provides useful and meaningful information about our ongoing R&D activities by enhancing investors' understanding of the scope of our normal, recurring operating R&D expenses.

Adjusted consolidated operating profit from our Commercial Platform, adjusted consolidated net income attributable to Chi-Med from our Commercial Platform and adjusted consolidated net income attributable to Chi-Med from our Prescription Drugs business: We exclude the impact of one-time gains which were triggered by the payment of R&D-related subsidies from the Shanghai government to SHPL.

Adjusted revenues of HBYS and non-consolidated joint ventures: We exclude the sales of Guanbao because Guanbao was divested by HBYS in September 2017.

Reconciliation of GAAP to adjusted consolidated operating profit from our Commercial Platform:

Reconciliation of GAAP to adjusted consolidated net income attributable to Chi-Med from our Commercial Platform:

Reconciliation of GAAP to adjusted consolidated net income attributable to Chi-Med from our Prescription Drugs business:

Reconciliation of GAAP to adjusted revenues of HBYS and non-consolidated joint ventures:

Hutchison China MediTech Limited
Condensed Consolidated Balance Sheets
(in US$'000, except share data)

	Note	June 30, 2018		December 31, 2017


		(Unaudited)
Assets
Current assets
Cash and cash equivalents	3	75,329		85,265
Short-term investments	4	247,165		273,031
Accounts receivable—third parties	5	44,419		38,410
Accounts receivable—related parties	18 (ii)	2,550		3,860
Other receivables, prepayments and deposits	6	14,315		11,296
Amounts due from related parties	18 (ii)	1,110		8,544
Inventories	7	9,788		11,789

Total current assets		394,676		432,195
Property, plant and equipment	8	14,416		14,220
Deferred tax assets	19 (ii)	681		633
Investments in equity investees	9	161,589		144,237
Other assets		6,581		6,647

Total assets		577,943		597,932



Liabilities and shareholders' equity
Current liabilities
Accounts payable	10	19,308		24,365
Other payables, accruals and advance receipts	11	49,669		40,953
Income tax payable	19 (iii)	1,167		979
Deferred revenue	16	3,753		1,295
Amounts due to related parties	18 (ii)	10,687		7,021
Short-term bank borrowings	12	—		29,987

Total current liabilities		84,584		104,600
Deferred tax liabilities	19 (ii)	5,052		4,452
Long-term bank borrowings	12	26,692		—
Deferred revenue	16	924		809
Other liabilities		2,846		3,105

Total liabilities		120,098		112,966
Commitments and contingencies	13
Company's shareholders' equity
Ordinary shares; $1.00 par value; 75,000,000 shares authorized; 66,532,683 and 66,447,037 shares issued at June 30, 2018 and December 31, 2017 respectively	14	66,533		66,447
Additional paid-in capital		497,517		496,960
Accumulated losses		(140,890	)	(107,104	)
Accumulated other comprehensive income		8,571		5,430

Total Company's shareholders' equity		431,731		461,733
Non-controlling interests		26,114		23,233

Total shareholders' equity		457,845		484,966

Total liabilities and shareholders' equity		577,943		597,932

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Hutchison China MediTech Limited
Condensed Consolidated Statements of Operations
(Unaudited, in US$'000, except share and per share data)

		Six Months Ended June 30,


	Note	2018		2017

Revenues
Sales—third parties	16	85,116		99,950
Sales—related parties	16	3,449		3,908
Revenue from license and collaboration agreements—third parties	16	8,548		17,843
Revenue from research and development services—related parties	16	5,076		4,883

Total revenues		102,189		126,584

Operating expenses
Costs of sales—third parties		(69,423	)	(86,528	)
Costs of sales—related parties		(2,455	)	(2,859	)
Research and development expenses	17	(60,053	)	(31,566	)
Selling expenses		(9,392	)	(9,681	)
Administrative expenses		(14,549	)	(12,015	)

Total operating expenses		(155,872	)	(142,649	)

Loss from operations		(53,683	)	(16,065	)
Other income/(expense)		3,188		(673	)

Loss before income taxes and equity in earnings of equity investees		(50,495	)	(16,738	)
Income tax expense	19 (i)	(2,680	)	(1,846	)
Equity in earnings of equity investees, net of tax	9	23,050		22,269

Net (loss)/income		(30,125	)	3,685
Less: Net income attributable to non-controlling interests		(2,566	)	(2,003	)

Net (loss)/income attributable to the Company		(32,691	)	1,682



(Losses)/earnings per share attributable to the Company—basic (US$ per share)	20 (i)	(0.49	)	0.03
(Losses)/earnings per share attributable to the Company—diluted (US$ per share)	20 (ii)	(0.49	)	0.03
Number of shares used in per share calculation—basic	20 (i)	66,389,454		60,660,846
Number of shares used in per share calculation—diluted	20 (ii)	66,389,454		61,134,539

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Hutchison China MediTech Limited
Condensed Consolidated Statements of Comprehensive (Loss)/Income
(Unaudited, in US$'000)

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Hutchison China MediTech Limited
Condensed Consolidated Statements of Changes in Shareholders' Equity
(Unaudited, in US$'000, except share data in '000)

	Ordinary Shares Number	Ordinary Shares Value	Additional Paid-in Capital		Accumulated Losses		Accumulated Other Comprehensive Income/(Loss)		Total Company's Shareholders' Equity		Non- controlling Interests		Total Equity


As at January 1, 2017	60,706	60,706	208,196		(80,357	)	(4,275	)	184,270		19,790		204,060
Net income	—	—	—		1,682		—		1,682		2,003		3,685
Issuances in relation to share option exercises	31	31	143		—		—		174		—		174
Share-based compensation
Share options	—	—	551		—		—		551		1		552
Long-term incentive plan ("LTIP")	—	—	1,125		—		—		1,125		1		1,126

	—	—	1,676		—		—		1,676		2		1,678

LTIP—treasury shares acquired and held by Trustee	—	—	(1,367	)	—		—		(1,367	)	—		(1,367	)
Dividend paid to a non-controlling shareholder of a subsidiary	—	—	—		—		—		—		(37	)	(37	)
Transfer between reserves	—	—	10		(10	)	—		—		—		—
Foreign currency translation adjustments	—	—	—		—		2,944		2,944		364		3,308

As at June 30, 2017	60,737	60,737	208,658		(78,685	)	(1,331	)	189,379		22,122		211,501



As at December 31, 2017	66,447	66,447	496,960		(107,104	)	5,430		461,733		23,233		484,966
Impact of change in accounting policy (Note 2)	—	—	—		(1,080	)	—		(1,080	)	(3	)	(1,083	)

As at January 1, 2018	66,447	66,447	496,960		(108,184	)	5,430		460,653		23,230		483,883
Net (loss)/income	—	—	—		(32,691	)	—		(32,691	)	2,566		(30,125	)
Issuances in relation to share option exercises	86	86	634		—		—		720		—		720
Share-based compensation
Share options	—	—	2,784		—		—		2,784		7		2,791
LTIP	—	—	2,575		—		—		2,575		7		2,582

	—	—	5,359		—		—		5,359		14		5,373

LTIP—treasury shares acquired and held by Trustee	—	—	(5,451	)	—		—		(5,451	)	—		(5,451	)
Transfer between reserves	—	—	15		(15	)	—		—		—		—
Foreign currency translation adjustments	—	—	—		—		3,141		3,141		304		3,445

As at June 30, 2018	66,533	66,533	497,517		(140,890	)	8,571		431,731		26,114		457,845

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Hutchison China MediTech Limited
Condensed Consolidated Statements of Cash Flows
(Unaudited, in US$'000)

		Six Months Ended June 30,


	Note	2018		2017

Net cash (used in)/generated from operating activities	22	(18,596	)	19,422

Investing activities
Purchases of property, plant and equipment		(2,079	)	(3,045	)
Deposits in short-term investments		(491,169	)	(16,000	)
Proceeds from short-term investments		517,035		40,270
Investment in an equity investee		(8,000	)	(7,000	)

Net cash generated from investing activities		15,787		14,225

Financing activities
Proceeds from issuance of ordinary shares	15 (i)	720		174
Purchases of treasury shares	15 (ii)	(5,451	)	(1,367	)
Proceeds from bank borrowings		26,923		22,551
Repayment of bank borrowings		(30,000	)	(22,564	)
Payment of issuance costs		(34	)	—
Dividends paid to a non-controlling shareholder of a subsidiary		—		(37	)

Net cash used in financing activities		(7,842	)	(1,243	)

Net (decrease)/increase in cash and cash equivalents		(10,651	)	32,404
Effect of exchange rate changes on cash and cash equivalents		715		697

		(9,936	)	33,101
Cash and cash equivalents
Cash and cash equivalents at beginning of period		85,265		79,431

Cash and cash equivalents at end of period		75,329		112,532

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Hutchison China MediTech Limited
Notes to the Unaudited Condensed Consolidated Financial Statements

Hutchison China MediTech Limited (the "Company") and its subsidiaries (together the "Group") are principally engaged in researching, developing, manufacturing and selling pharmaceuticals and healthcare products. The Group and its equity investees have research and development facilities and manufacturing plants in the People's Republic of China (the "PRC") and sell their products mainly in the PRC and Hong Kong.

As at June 30, 2018, the Group had accumulated losses of US$140,890,000, primarily due to its significant spending in drug research and development ("Drug R&D") activities. The Group regularly monitors current and expected liquidity requirements to ensure that it maintains sufficient cash balances and adequate credit facilities to meet its liquidity requirements in the short and long term. As at June 30, 2018, the Group had cash and cash equivalents of US$75,329,000, short-term investments of US$247,165,000 and unutilized bank borrowing facilities of US$94,359,000. Short-term investments comprised of bank deposits maturing over three months. As at December 31, 2017, the Group had cash and cash equivalents of US$85,265,000, short-term investments of US$273,031,000 and unutilized bank borrowing facilities of US$121,282,000. The Group's operating plan includes the continued receipt of dividends from certain of its equity investees. Dividends received from equity investees for the six months ended June 30, 2018 and 2017 were US$23,526,000 and US$42,617,000 respectively.

Based on the Group's operating plan, the existing cash and cash equivalents, short-term investments and unutilized bank borrowing facilities are considered to be sufficient to meet the cash requirements to fund planned operations and other commitments for at least the next twelve months (the look-forward period used).

The accompanying interim unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America ("U.S. GAAP") for interim financial information. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements, except for the adoption of Accounting Standards Update ("ASU") 2014-09, Revenue from Contracts with Customers (Topic 606) ("ASC 606") as described below. In the opinion of management, all adjustments, consisting of normal recurring adjustments necessary for the fair statement of results for the periods presented, have been included. The results of operations of any interim period are not necessarily indicative of the results of operations for the full year or any other interim period.

The comparative year-end condensed balance sheet data was derived from the annual audited consolidated financial statements, but does not include all disclosures required by U.S. GAAP.

The interim unaudited condensed consolidated financial statements and related disclosures have been prepared with the presumption that users have read or have access to the annual audited consolidated financial statements for the preceding fiscal year.

The preparation of these interim unaudited condensed consolidated financial statements in conformity with U.S. GAAP required management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities as at the end of the reporting period and the reported amounts of revenues and expenses during the reporting period. Estimates are used in determining items such as useful lives of property, plant and equipment, write-down of inventories, allowance for doubtful accounts, share-based compensation, impairments of long-lived assets, impairment of other intangible asset and goodwill, income tax expense, tax valuation allowances and revenues from research and development projects. Actual results could differ from those estimates.

The Group applied ASC 606 to all contracts at the date of initial application of January 1, 2018. As a result, the Group has changed its accounting policy for revenue recognition as detailed below. The Group applied ASC 606 using the modified retrospective method by recognizing the cumulative effect as an adjustment to opening accumulated losses at January 1, 2018. The comparative information prior to January 1, 2018 has not been adjusted and continues to be reported under Accounting Standard Codification 605, Revenue Recognition (Topic 605) ("ASC 605").

The Group assessed its license and collaboration contracts under ASC 606. Refer to Note 16. As a result of this assessment, the Group recorded an aggregate US$1.1 million deferral of revenue as a cumulative adjustment to opening accumulated losses upon adoption.

For sales of goods and services, the Group applied a portfolio approach to aggregate contracts into portfolios whose performance obligations do not differ materially from each other. In its assessment of each portfolio, the Group assessed the contracts under the new five-step model under ASC 606 and determined there was no significant impact to the timing or amount of revenue recognition under the new guidance.

Under the Group's previous accounting policy, deferred revenue comprised deferred upfront payments from the Group's license and collaboration contracts. Under ASC 606, advance payments from customers preceding an entity's performance are considered contract liabilities; therefore, advance payments from customers from the Group's Commercial Platform have been reclassified from other payables, accruals and advance receipts to deferred revenue. Expected rebates for sales of goods remain in other payables, accruals and advance receipts.

The following tables summarize the impact of adopting ASC 606 on the Group's unaudited condensed consolidated financial statements as at and for the six months ended June 30, 2018, as compared to the amounts as if applying ASC 605:

	As reported ASC 606		Adjustments		As if applied ASC 605


	(in US$'000)
Condensed Consolidated Balance Sheet
Current assets	394,676		—		394,676
Non-current assets	183,267		—		183,267

Total assets	577,943		—		577,943



Liabilities and shareholders' equity
Current liabilities
Other payables, accruals and advance receipts	49,669		1,754		51,423
Deferred revenue	3,753		(2,434	)	1,319
Other current liabilities	31,162		—		31,162

Total current liabilities	84,584		(680	)	83,904
Deferred revenue	924		(267	)	657
Other non-current liabilities	34,590		—		34,590

Total liabilities	120,098		(947	)	119,151
Company's shareholders' equity
Accumulated losses	(140,890	)	916		(139,974	)
Accumulated other comprehensive income	8,571		28		8,599
Other shareholders' equity	564,050		—		564,050

Total Company's shareholders' equity	431,731		944		432,675
Non-controlling interests	26,114		3		26,117

Total shareholders' equity	457,845		947		458,792

Total liabilities and shareholders' equity	577,943		—		577,943

	As reported ASC 606		Adjustments		As if applied ASC 605


	(in US$'000)
Condensed Consolidated Statement of Operations
Total revenues	102,189		(164	)	102,025
Total operating expense	(155,872	)	—		(155,872	)

Loss from operations	(53,683	)	(164	)	(53,847	)
Total other income	3,188		—		3,188

Loss before income taxes and equity in earnings of equity investees	(50,495	)	(164	)	(50,659	)
Income tax expense	(2,680	)	—		(2,680	)
Equity in earnings of equity investees, net of tax	23,050		—		23,050

Net loss	(30,125	)	(164	)	(30,289	)
Less: Net income attributable to non-controlling interests	(2,566	)	—		(2,566	)

Net loss attributable to the Company	(32,691	)	(164	)	(32,855	)

	As reported ASC 606		Adjustments		As if applied ASC 605


	(in US$'000)
Condensed Consolidated Statement of Comprehensive Loss
Net loss	(30,125	)	(164	)	(30,289	)
Other comprehensive income	3,445		28		3,473

Total comprehensive loss	(26,680	)	(136	)	(26,816	)
Less: Comprehensive income attributable to non-controlling interests	(2,870	)	—		(2,870	)

Total comprehensive loss attributable to ordinary shareholders of the Company	(29,550	)	(136	)	(29,686	)

There are no adjustments to net cash (used in)/generated from operating activities, investing activities or financing activities in the condensed consolidated statement of cash flows.

Revenue is measured based on consideration specified in a contract with a customer, and excludes any sales incentives and amounts collected on behalf of third parties. Taxes assessed by a governmental authority that are both imposed on and concurrent with a specific revenue-producing transaction, that are collected by the Group from a customer, are also excluded from revenue. The Group recognizes revenue when it satisfies a performance obligation by transferring control over a good, service or license to a customer.

The following is a description of principal activities, separated by reportable segments, from which the Company generates its revenue:

The Innovation Platform reportable segment principally generates revenue from license and collaboration contracts. The license and collaboration contracts generally contain multiple performance obligations including (1) the license to the drug compound and (2) the research and development services for each specified treatment indication, which are accounted for separately if they are distinct, i.e. if a product or service is separately identifiable from other items in the arrangement and if a customer can benefit from it on its own or with other resources that are readily available to the customer.

The transaction price generally includes fixed and variable consideration in the form of upfront payment, research and development cost reimbursements, contingent milestone payments and sales-based royalties. Contingent milestone payments are not included in the transaction price until it becomes probable that a significant reversal of revenue will not occur, which is generally when the specified milestone is achieved. The allocation of the transaction price to each performance obligation is based on the relative standalone selling prices of each performance obligation determined at the inception of the contract. The Group estimates the standalone selling prices based on the income approach. Control of the license to the drug compounds transfers at the inception date of the collaboration agreements and consequently, amounts allocated to this performance obligation are generally recognized at a point in time. Conversely, research and development services for each specified indication are performed over time and amounts allocated to these performance obligations are generally recognized over time using cost inputs as

a measure of progress. The Group has determined that research and development expenses provide an appropriate depiction of measure of progress for the research and development services. Changes to estimated cost inputs may result in a cumulative catch-up adjustment. Royalty revenues are recognized as future sales occur as they meet the requirements for the sales-usage based royalty exception.

Deferred revenue is recognized if allocated consideration is received in advance of the Group rendering research and development services. Accounts receivable is recognized based on the terms of the contract and when the Group has an unconditional right to bill the customer, which is generally when research and development services are rendered.

The Commercial Platform reportable segment principally generates revenue from (1) sales of goods, which are the manufacture or purchase and distribution of drug, healthcare and consumer products, and (2) sales of services, which are the provision of sales, distribution and marketing services to pharmaceutical manufacturers. These contracts include prescription drug products and consumer health products.

Revenue from sales of goods is recognized when the customer takes possession of the goods. This usually occurs upon completed delivery of the goods to the customer site. The amount of revenue recognized is adjusted for expected sales incentives as stipulated in the contract, which are generally issued to customers as direct discounts at the point-of-sale or indirectly in the form of rebates. Sales incentives are estimated using the expected value method. Additionally, sales are generally made with a limited right of return under certain conditions. Revenues are recorded net of provisions for sales discounts and returns.

Revenue from sales of services is recognized when the benefits of the services transfer to the customer over time.

Deferred revenue is recognized if consideration is received in advance of transferring control of the goods or rendering of services. Accounts receivable is recognized if the Group has an unconditional right to bill the customer, which is generally when the customer takes possession of the goods or services are rendered. Payment terms differ by subsidiary and customer, but generally range from 45 to 180 days from the invoice date.

Refer to the recent accounting pronouncements in the annual audited consolidated financial statements for the preceding fiscal year. The following includes updates and new accounting pronouncements since the issuance of the annual audited consolidated financial statements.

In February 2016, the Financial Accounting Standards Board ("FASB") issued ASU 2016-02, Leases (Topic 842) ("ASU 2016-02"). The core principle of ASU 2016-02 is that a lessee should recognize the assets and liabilities that arise from leases. A lessee should recognize in the balance sheet a liability to make lease payments (the lease liability) and a right-of-use asset representing its right to use the underlying asset for the lease term. For leases with a term of 12 months or less, a lessee is permitted to make an accounting policy election by class of underlying asset not to recognize lease assets and lease liabilities. ASU 2016-02 is effective for fiscal years and interim periods within those years beginning after December 15, 2018. The Group expects to adopt the new standard using the modified retrospective method on January 1, 2019 with a retrospective adjustment to comparable periods starting from January 1, 2017, subject to further implementation guidance issued by the FASB. The Group is continuing to evaluate the impact of the new guidance, but expects a gross up to the consolidated balance sheets on the date of

adoption primarily related to the Group's various factories and offices under non-cancellable lease agreements (Note 13) and are currently accounted off-balance sheet as operating leases under Accounting Standard Codification 840, Leases (Topic 840). Additionally, the Group expects limited impact to the consolidated statements of operations after adoption as the pattern of rental expense recognition should not change materially for such operating leases.

In June 2018, the FASB issued ASU 2018-07, Improvements to Nonemployee Share-Based Payment Accounting ("ASU 2018-07"), which simplifies the accounting for share-based payments granted to nonemployees for goods and services. Under the ASU, most of the guidance on such payments to nonemployees would be aligned with the requirements for share-based payments granted to employees. ASU 2018-07 is effective for fiscal years and interim periods within those years beginning after December 15, 2018. The Group shall adopt the guidance on January 1, 2019, but does not expect a significant impact upon adoption as there have been no nonemployee stock option grants during any periods presented.

Other amendments that have been issued by the FASB or other standards-setting bodies that do not require adoption until a future date are not expected to have a material impact on the Group's consolidated financial statements upon adoption.

	June 30, 2018	December 31, 2017


	(in US$'000)
Cash at bank and on hand	57,209	30,018
Bank deposits maturing in three months or less (note (a))	18,120	55,247

	75,329	85,265



Denominated in:
United States dollar ("US$") (note (b))	55,761	66,381
Renminbi ("RMB") (note (b))	15,186	15,140
UK Pound Sterling ("£") (note (b))	725	295
Hong Kong dollar ("HK$")	3,657	3,449

	75,329	85,265

Substantially all the accounts receivable are denominated in RMB, US$ and HK$ and are due within one year from the end of the reporting period. The carrying values of accounts receivable approximate their fair values due to their short-term maturities.

Inventories, net of provision for excess and obsolete inventories, consisted of the following:

	Buildings	Leasehold improvements	Plant and equipment	Furniture and fixtures, other equipment and motor vehicles		Construction in progress		Total


	(in US$'000)
Cost
As at January 1, 2018	2,372	9,057	2,568	15,154		2,558		31,709
Additions	—	80	2	492		1,021		1,595
Disposals	—	—	—	(68	)	—		(68	)
Transfers	—	209	748	208		(1,165	)	—
Exchange differences	40	141	38	243		45		507

As at June 30, 2018	2,412	9,487	3,356	16,029		2,459		33,743

Accumulated depreciation
As at January 1, 2018	1,141	5,296	499	10,553		—		17,489
Depreciation	56	569	159	851		—		1,635
Disposals	—	—	—	(62	)	—		(62	)
Exchange differences	18	79	6	162		—		265

As at June 30, 2018	1,215	5,944	664	11,504		—		19,327

Net book value
As at June 30, 2018	1,197	3,543	2,692	4,525		2,459		14,416

	Buildings	Leasehold improvements	Plant and equipment	Furniture and fixtures, other equipment and motor vehicles		Construction in progress		Total


	(in US$'000)
Cost
As at January 1, 2017	2,232	6,296	86	13,976		1,760		24,350
Additions	—	228	39	509		2,269		3,045
Disposals	—	—	—	(12	)	—		(12	)
Transfers	—	128	1,300	(847	)	(581	)	—
Exchange differences	40	113	3	247		44		447

As at June 30, 2017	2,272	6,765	1,428	13,873		3,492		27,830

Accumulated depreciation
As at January 1, 2017	971	4,249	71	9,105		—		14,396
Depreciation	52	410	55	746		—		1,263
Disposals	—	—	—	(11	)	—		(11	)
Transfers	—	—	239	(239	)	—		—
Exchange differences	18	77	1	162		—		258

As at June 30, 2017	1,041	4,736	366	9,763		—		15,906

Net book value
As at June 30, 2017	1,231	2,029	1,062	4,110		3,492		11,924

All of the equity investees are private companies and there are no quoted market prices available for their shares.

Summarized financial information for the significant equity investees is as follows:

	Commercial Platform								Innovation Platform


	Consumer Health HBYS				Prescription Drugs SHPL				Drug R&D NSPL

	June 30, 2018		December 31, 2017		June 30, 2018		December 31, 2017		June 30, 2018		December 31, 2017

	(in US$'000)
Current assets	121,229		101,570		134,355		129,535		20,627		9,640
Non-current assets	108,263		107,226		103,468		103,477		30,000		30,000
Current liabilities	(82,693	)	(75,787	)	(87,274	)	(91,665	)	(1,044	)	(1,239	)
Non-current liabilities	(18,839	)	(18,748	)	(8,202	)	(8,616	)	—		—

Net assets	127,960		114,261		142,347		132,731		49,583		38,401
Non-controlling interests	(3,668	)	(3,645	)	—		—		—		—

	124,292		110,616		142,347		132,731		49,583		38,401

	Commercial Platform								Innovation Platform


	Consumer Health HBYS				Prescription Drugs SHPL				Drug R&D NSPL

	Six Months Ended June 30,				Six Months Ended June 30,				Six Months Ended June 30,

	2018		2017		2018		2017		2018		2017

	(in US$'000)
Revenue	118,983		123,408		152,717		129,718		—		—



Gross profit	59,155		45,933		108,802		94,964		—		—



Interest income	37		79		407		498		43		—



Finance cost	(135	)	(58	)	—		—		—		—



Profit/(loss) before taxation	14,306		13,525		45,942		43,727		(4,818	)	(4,749	)
Income tax expense (note)	(2,362	)	(1,942	)	(7,127	)	(5,984	)	—		—

Net income/(loss)	11,944		11,583		38,815		37,743		(4,818	)	(4,749	)
Non-controlling interests	39		(61	)	—		—		—		—

Net income/(loss) attributable to the shareholders of equity investee	11,983		11,522		38,815		37,743		(4,818	)	(4,749	)

For the six months ended June 30, 2018 and 2017, other immaterial equity investees had net income of approximately US$120,000 and US$22,000 respectively.

Reconciliation of the summarized financial information presented to the carrying amount of investments in equity investees is as follows:

	Commercial Platform							Innovation Platform


	Consumer Health HBYS			Prescription Drugs SHPL				Drug R&D NSPL

	2018	2017		2018		2017		2018		2017

	(in US$'000)
Opening net assets after non-controlling interests as at January 1	110,616	127,072		132,731		150,134		38,401		33,611
Net income/(loss) attributable to the shareholders of equity investee	11,983	11,522		38,815		37,743		(4,818	)	(4,749	)
Dividends declared	—	(14,615	)	(31,538	)	(70,619	)	—		—
Other comprehensive income	1,693	2,330		2,339		2,889		—		—
Investments	—	—		—		—		16,000		14,000

Closing net assets after non-controlling interests as at June 30	124,292	126,309		142,347		120,147		49,583		42,862



Group's share of net assets	62,146	63,154		71,173		60,074		24,792		21,431
Goodwill	—	—		3,103		2,923		—		—

Carrying amount of investments as at June 30	62,146	63,154		74,276		62,997		24,792		21,431

The equity investees had the following lease commitments and capital commitments:

Substantially all the accounts payable are denominated in RMB and US$ and due within one year from the end of the reporting period. The carrying values of accounts payable approximate their fair values due to their short-term maturities.

	June 30, 2018	December 31, 2017


	(in US$'000)
Accrued salaries and benefits	7,904	9,295
Accrued research and development expenses	23,908	14,613
Accrued selling expenses and rebates	5,524	4,121
Accrued administrative and other general expenses	4,843	4,729
Deferred government incentives	1,936	1,790
Loan from a non-controlling shareholder of a subsidiary (Note 18 (iv))	1,550	1,550
Deposits (note)	1,386	1,282
Others	2,618	3,573

	49,669	40,953

The weighted average interest rate for outstanding bank borrowings for the six months ended June 30, 2018 and the year ended December 31, 2017 was 2.33% per annum and 1.90% per annum respectively. In addition, the Group incurred guarantee fees of nil and US$320,000 for the six months ended June 30, 2018 and the year ended December 31, 2017 respectively, which was nil and 0.76% per annum respectively of the weighted average outstanding bank borrowings. The carrying amounts of the Group's bank borrowings are all denominated in HK$.

In November 2017, the Group through its subsidiary, entered into facility agreements with a bank for the provision of unsecured credit facilities in the aggregate amount of HK$400,000,000 (US$51,282,000). The credit facilities include (i) a HK$210,000,000 (US$26,923,000) 3-year term loan facility and (ii) a HK$190,000,000 (US$24,359,000) 18-month revolving loan facility. The term loan bears interest at 1.50% over the Hong Kong Interbank Offered Rate ("HIBOR") per annum and an upfront fee of HK$1,575,000 (US$202,000). The revolving loan facility bears interest at 1.25% over HIBOR per annum. The term loan was drawn in May 2018 and is due in November 2020. Accordingly, the term loan is recorded under long-term bank borrowings as at June 30, 2018. As at June 30, 2018 and December 31, 2017, no amount has been drawn from the revolving loan facility. These credit facilities are guaranteed by the Company.

In February 2017, the Group through its subsidiary, entered into two separate facility agreements with banks for the provision of unsecured credit facilities in the aggregate amount of HK$546,000,000 (US$70,000,000). The first credit facility includes (i) a HK$156,000,000 (US$20,000,000) term loan facility and (ii) a HK$195,000,000 (US$25,000,000) revolving loan facility, both with a term of 18 months and an annual interest rate of 1.25% over HIBOR. The second credit facility includes (i) a HK$78,000,000 (US$10,000,000) term loan facility and (ii) a HK$117,000,000 (US$15,000,000) revolving loan facility, both with a term of 18 months and an annual interest rate of 1.25% over HIBOR. The term loans from the first and second credit facilities were repaid and terminated in May 2018. As at June 30, 2018 and December 31, 2017, no amount has been drawn from either of the revolving loan facilities which are guaranteed by the Company.

In November 2015, the Group through its subsidiary renewed a three year revolving loan facility with a bank in the aggregate amount of HK$234,000,000 (US$30,000,000) with an annual interest rate of 1.25% over HIBOR. This facility will expire in November 2018. In February 2017, HK$20,000,000 (US$2,564,000) was drawn from this facility and the amount was fully repaid in March 2017. As at June 30, 2018 and December 31, 2017, there were no amounts due under this loan.

The Group's bank borrowings are repayable as from the dates indicated as follows:

As at June 30, 2018 and December 31, 2017, the Group had unutilized bank borrowing facilities of HK$736,000,000 (US$94,359,000) and HK$946,000,000 (US$121,282,000) respectively.

The Group leases various factories and offices under non-cancellable operating lease agreements. Future aggregate minimum payments under non-cancellable operating leases as from the dates indicated are as follows:

In addition, the Group has also undertaken to provide the necessary additional funds for NSPL to finance its ongoing operations. The Group does not have any other significant commitments or contingencies.

The Company is authorized to issue 75,000,000 ordinary shares. A summary of ordinary share transactions (in thousands) is as follows:

Each ordinary share is entitled to one vote. The holders of ordinary shares are also entitled to receive dividends whenever funds are legally available and when declared by the Board of Directors of the Company.

The Company conditionally adopted a share option scheme on June 4, 2005 (as amended on March 21, 2007) and such scheme has a term of 10 years. It expired in 2016 and no further share options can be granted. Another share option scheme was conditionally adopted on April 24, 2015 (the "HCML Share Option Scheme"). Pursuant to the HCML Share Option Scheme, the Board of Directors of the Company may, at its discretion, offer any employees and directors (including Executive and Non-executive Directors but excluding Independent Non-executive Directors) of the Company, holding companies of the Company and any of their subsidiaries or affiliates, and subsidiaries or affiliates of the Company, share options to subscribe for shares of the Company.

The aggregate number of shares issuable under the HCML Share Option Scheme is 2,425,597 ordinary shares. The aggregate number of shares issuable under the prior share option scheme which expired in 2016 is 197,080 ordinary shares. As at June 30, 2018, the number of shares authorized but unissued was 8,467,317 ordinary shares.

Share options granted are generally subject to a four-year vesting schedule, depending on the nature and the purpose of the grant. Share options subject to the four-year vesting schedule, in general, vest 25% upon the first anniversary of the vesting commencement date as defined in the grant letter, and 25% every subsequent year. However, certain share option grants may have a different vesting schedule as approved by the Board of Directors of the Company. No outstanding share options will be exercisable or subject to vesting after the expiry of a maximum of eight to ten years from the date of grant.

A summary of the Company's share option activity and related information is as follows:

	Number of share options		Weighted average exercise price in £ per share	Weighted average remaining contractual life (years)	Aggregate intrinsic value (in £'000)


Outstanding at January 1, 2017	1,039,596		15.00	6.77	7,900
Granted	150,000		31.05
Exercised	(56,309	)	5.16
Cancelled	(6,875	)	6.10

Outstanding at December 31, 2017	1,126,412		17.69	6.29	43,158
Granted	949,626		46.78
Exercised	(85,646	)	6.10

Outstanding at June 30, 2018	1,990,392		32.07	7.72	28,530



Vested and exercisable at December 31, 2017	951,412		15.52	5.81	38,508
Vested and exercisable at June 30, 2018	928,266		17.13	5.46	26,702

In estimating the fair value of share options granted, the following assumptions were used in the Polynomial model for awards granted in the periods indicated:

	Year Ended December 31,				Six Months Ended June 30,

	2011	2013	2016	2017	2018
Weighted average grant date fair value of share options (in £ per share)	1.84	3.15	8.99	12.69	16.71
Significant inputs into the valuation model (weighted average):
Exercise price (in £ per share)	4.41	6.10	19.70	31.05	46.78
Share price at effective date of grant (in £ per share)	4.33	6.10	19.70	31.05	46.57
Expected volatility (note (a))	46.6%	36.0%	39.0%	36.3%	37.7%
Risk-free interest rate (note (b))	3.13%	3.16%	1.00%	1.17%	1.47%
Contractual life of share options (in years)	10	10	8	10	10
Expected dividend yield (note (c))	0%	0%	0%	0%	0%

The Company will issue new shares to satisfy share option exercises. The following table summarizes the Company's share option exercises:

The Group recognizes compensation expense for only the portion of options expected to vest, on a graded vesting approach over the requisite service period. The following table presents share-based compensation expense:

As at June 30, 2018, the total unrecognized compensation cost was US$20,937,000 and will be recognized on a graded vesting approach over the weighted average remaining service period of 3.75 years.

The Company grants awards under the LTIP to participating directors and employees, giving them a conditional right to receive ordinary shares of the Company or the equivalent American depositary shares ("ADS") (collectively the "Awarded Shares") to be purchased by the Trustee up to a cash amount. Vesting will depend upon continued employment of the award holder with the Group and will otherwise be at the discretion of the Board of Directors of the Company. Additionally, some awards are subject to change based on annual performance targets prior to their determination date.

Performance targets vary by award, and may include targets for shareholder returns, free cash flows, revenues, net profit after taxes and the achievement of clinical and regulatory milestones. As the extent of achievement of the performance targets is uncertain prior to the determination date, a probability based on management's assessment on the achievement of the performance target has been assigned to calculate the amount to be recognized as an expense over the requisite period with a corresponding entry to liability.

Upon the determination date, the Company will pay a determined monetary amount, up to the maximum cash amount based on the actual achievement of the performance target specified in the award, to the Trustee to purchase the Awarded Shares. Any cumulative compensation expense previously recognized as a liability will be transferred to additional paid-in capital, as an equity-settled award. If the performance target is not achieved, no Awarded Shares of the Company will be purchased and the amount previously recorded in the liability will be reversed through profit or loss.

On December 15, 2017, the Company granted awards up to a maximum cash amount per annum of US$0.5 million that stipulated annual performance targets. Shares under such LTIP awards will cover each financial year from 2018 to 2019. The annual performance target determination date is the date of the announcement of the Group's annual results for the covered financial year and vesting occurs two business days after the announcement of the Group's annual results for the financial year falling two years after the covered financial year to which the LTIP award relates.

On March 15, 2017 and August 2, 2017, the Company granted awards up to a maximum cash amount per annum of US$6.0 million that stipulated annual performance targets. Shares under such LTIP awards will cover each financial year from 2017 to 2019. The annual performance target determination date is the date of the announcement of the Group's annual results for the covered financial year and vesting occurs two business days after the announcement of the Group's annual results for the financial year falling two years after the covered financial year to which the LTIP award relates.

On March 15, 2017, the Company granted awards up to a maximum cash amount of US$0.4 million in aggregate that did not stipulate performance targets. Shares under such LTIP awards vested one business day after the publication date of the annual report for the 2017 financial year.

The Trustee has been set up solely for the purpose of purchasing and holding the Awarded Shares during the vesting period on behalf of the Group using funds provided by the Group. On the determination date, if any, the Company will determine the cash amount, based on the actual achievement of each annual performance target, for the Trustee to purchase the Awarded Shares. The Awarded Shares will then be held by the Trustee until they are vested.

The Trustee's assets include treasury shares and funds for additional treasury shares, trustee fees and expenses. The number of treasury shares (in the form of ordinary shares or ADS of the Company) purchased and held by the Trustee are as follows:

For the six months ended June 30, 2018, US$93,000 of the determined LTIP awards have been forfeited.

The following table presents the share-based compensation expenses recognized under the LTIP awards:

For the six months ended June 30, 2018 and 2017, US$1,770,000 and US$451,000 was reclassified from liability to additional paid-in capital respectively upon LTIP awards reaching the determination date. As at June 30, 2018 and December 31, 2017, US$1,260,000 and US$2,241,000 was recorded as liability respectively for LTIP awards prior to the determination date.

As at June 30, 2018, the total unrecognized compensation cost was approximately US$6,679,000, which considers expected performance targets and the amount expected to vest, and will be recognized over the requisite periods.

The following table presents revenue disaggregated by customers and major product lines, and reconciles disaggregated revenue with reportable segments:

For the six months ended June 30, 2018, revenue of US$1.2 million was recognized that was included in the deferred revenue balance as at January 1, 2018 (which includes US$2.1 million deferred revenue as at December 31, 2017, US$0.7 million of payments in advance from customers reclassified from other payables, accruals and advance receipts (Note 11) and US$1.1 million cumulative adjustment upon adoption of ASC 606). Estimated deferred revenue to be recognized over time as from the date indicated is as follows:

Innovation Platform revenue is mainly from license and collaboration agreements as follows:

On October 8, 2013, the Group entered into a licensing, co-development and commercialization agreement in China with Eli Lilly ("Lilly") relating to fruquintinib ("Lilly Agreement"), a targeted oncology therapy for the treatment of various types of solid tumors. Under the terms of the Lilly Agreement, the Group is entitled to receive a series of payments up to US$86.5 million, including upfront payments and development and regulatory approval milestones. Should fruquintinib be successfully commercialized in China, the Group would receive tiered royalties from 15% to 20% on all sales in China. Development costs after the first development milestone are shared between the Group and Lilly.

Upfront and milestone payments in the Lilly Agreement are summarized as follows:

In addition, the Group also signed an option agreement which grants Lilly an exclusive option to expand the fruquintinib rights beyond Hong Kong and China. The option agreement further sets out certain milestone payments and royalty rates that apply in the event the option is exercised on a global basis. However, these are subject to further negotiation should the option be exercised on a specific territory basis as opposed to a global basis. The option was determined at the inception of the contract to have minimal value. As at June 30, 2018, the option has not been exercised.

The Group adopted ASC 606 on January 1, 2018 and reassessed the Lilly Agreement under the new standard, which resulted in US$0.1 million recognition of previously deferred revenue as a cumulative adjustment to opening accumulated losses as at January 1, 2018, summarized as follows (in US$ millions).

Under ASC 606, the Group identified the following performance obligations under the Lilly Agreement: (1) the license to fruquintinib and (2) the research and development services for the specified indications. The transaction price includes the upfront payment, research and development cost reimbursements, milestone payments and sales-based royalties. Milestone payments were not included in the transaction price until it became probable that a significant reversal of revenue would not occur, which is generally when the specified milestone is achieved. The allocation of the transaction price to each performance obligation was based on the relative standalone selling prices of each performance obligation determined at the inception of the contract. Based on this estimation, proportionate amounts of transaction price to be allocated to the license to fruquintinib and the research and development services were 90% and 10% respectively. Control of the license to fruquintinib transferred at the inception date of the agreement and consequently, amounts allocated to this performance obligation were recognized at inception. Conversely, research and development services for each specified indication are performed over

time and amounts allocated are recognized over time using the prior and estimated future development costs for fruquintinib as a measure of progress.

Under ASC 606, the Group recognized US$5.7 million, US$0.1 million and US$0.2 million revenue during the six months ended June 30, 2018 for research and development cost reimbursements, the amortization of the upfront payment and the amortization of the milestone payments respectively.

Under ASC 605, the Group recognized US$6.0 million, US$0.5 million and US$4.5 million revenue during the six months ended June 30, 2017 for research and development services, amortization of the upfront payment and the achievement of the milestone in relation to the acceptance of a new drug application by the China Food and Drug Administration (now the China National Drug Administration) for fruquintinib as a treatment of patients with advanced colorectal cancer respectively.

On December 21, 2011 (as amended on August 1, 2016), the Group and AstraZeneca ("AZ") entered into a global licensing, co-development, and commercialization agreement for savolitinib ("AZ Agreement"), a novel targeted therapy and a highly selective inhibitor of the c-Met receptor tyrosine kinase for the treatment of cancer. Under the terms of the AZ Agreement, the Group is entitled to receive a series of payments including upfront payments and development, first-sale and commercial sale milestones. Should savolitinib be successfully commercialized outside China, the Group would receive tiered royalties from 14% to 18% on all sales outside of China. After total aggregate sales of savolitinib have reached US$5 billion, this royalty will step down over a two-year period to an ongoing tiered royalty rate from 10.5% to 14.5%. Should savolitinib be successfully commercialized in China, the Group would receive fixed royalties of 30% based on all sales in China. Development costs for savolitinib in China will be shared between the Group and AZ, with the Group continuing to lead the development in China. AZ will lead and pay for the development of savolitinib for the rest of the world, except for Phase III clinical trial costs related to developing savolitinib for papillary renal cell carcinoma which the Group shall pay for up to a maximum of US$50 million.

The Group adopted ASC 606 on January 1, 2018 and reassessed the AZ Agreement under the new standard, which resulted in US$1.2 million deferral of previously recognized revenue as a cumulative adjustment to opening accumulated losses as at January 1, 2018, summarized as follows (in US$ millions).

Under ASC 606, the Group identified the following performance obligations under the AZ Agreement: (1) the license to savolitinib and (2) the research and development services for the specified indications. The transaction price includes the upfront payment, research and development cost reimbursements, milestone payments and sales-based royalties. Milestone payments were not included in the transaction price until it became probable that a significant reversal of revenue would not occur, which is generally when the specified milestone is achieved. The allocation of the transaction price to each performance obligation was based on the relative standalone selling prices of each performance obligation determined at the inception of the contract. Based on this estimation, proportionate amounts of transaction price to be allocated to the license to savolitinib and the research and development services were 95% and 5% respectively. Control of the license to savolitinib transferred at the inception date of the agreement and consequently, amounts allocated to this performance obligation were recognized at inception. Conversely, research and development services for each specified indication are performed over time and amounts allocated are recognized over time using the prior and estimated future development costs for savolitinib as a measure of progress.

Under ASC 606, the Group recognized US$2.4 million, US$0.1 million and US$0.1 million revenue during the six months ended June 30, 2018 for research and development cost reimbursements, the amortization of the upfront payment and the amortization of milestone payments respectively.

Under ASC 605, the Group recognized US$1.8 million, approximately US$0.1 million and US$5.0 million revenue during the six months ended June 30, 2017 for research and development services, amortization of the upfront payment and the achievement of the milestone in relation to the Phase III initiation for the secondary indication papillary renal cell carcinoma respectively.

18. Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries

The Group has the following significant transactions with related parties and non-controlling shareholders of subsidiaries, which were carried out in the normal course of business at terms determined and agreed by the relevant parties.

	Six Months Ended June 30,


	2018	2017

	(in US$'000)
Sales to:
Indirect subsidiaries of CK Hutchison	3,449	3,908



Revenue from research and development services from:
Equity investees	5,076	4,883



Purchases from:
Equity investees	1,197	494



Rendering of marketing services from:
Indirect subsidiaries of CK Hutchison	256	241
An equity investee	6,561	5,125

	6,817	5,366



Rendering of management services from:
An indirect subsidiary of CK Hutchison	455	448



Interest paid to:
An indirect subsidiary of CK Hutchison	—	65



Guarantee fee on bank borrowing to:
An indirect subsidiary of CK Hutchison	—	234

	June 30, 2018	December 31, 2017


	(in US$'000)
Accounts receivable—related parties
Indirect subsidiaries of CK Hutchison (note (a))	1,738	2,761
Equity investees (note (a))	812	1,099

	2,550	3,860



Accounts payable
An equity investee (note (a))	—	20



Amounts due from related parties
An indirect subsidiary of CK Hutchison (note (a))	—	23
Equity investees (note (a))	1,110	893
Dividend receivable from an equity investee	—	7,628

	1,110	8,544



Amounts due to related parties
An indirect subsidiary of CK Hutchison (note (b))	285	454
An equity investee (note (a))	10,402	6,567

	10,687	7,021



Other deferred income
An equity investee (note (c))	1,558	1,648

(iv) Balances with non-controlling shareholders of subsidiaries included in:

Notes:

(a): The Company, two subsidiaries incorporated in the British Virgin Islands and its Hong Kong subsidiaries are subject to Hong Kong profits tax which has been provided for at the rate of 16.5% on the estimated assessable profits less estimated available tax losses in each entity.
(b): Taxation in the PRC has been provided for at the applicable rate on the estimated assessable profits less estimated available tax losses, if any, in each entity. Under the PRC Enterprise Income Tax Law (the "EIT Law"), the standard enterprise income tax rate is 25%. In addition, the EIT Law provides for, among others, a preferential tax rate of 15% for companies which qualify as HNTE. HMPL qualifies as a HNTE up to December 31, 2019. Pursuant to the EIT law, a 10% withholding tax is levied on dividends declared by PRC companies to their foreign investors. A lower withholding tax rate of 5% is applicable under the China-HK Tax Arrangement if direct foreign investors with at least 25% equity interest in the PRC companies are Hong Kong tax residents, and meet the conditions or requirements pursuant to the relevant PRC tax regulations regarding beneficial ownership. Since the equity holders of the major subsidiaries and equity investees of the Company are Hong Kong incorporated companies and Hong Kong tax residents, and meet the aforesaid conditions or requirements, the Company has used 5%

The reconciliation of the Group's reported income tax expense to the theoretical tax amount that would arise using the tax rates of the Company against the Group's loss before income taxes and equity in earnings of equity investees is as follows:

	Six Months Ended June 30,


	2018		2017

	(in US$'000)
Loss before income taxes and equity in earnings of equity investees	(50,495	)	(16,738	)



Tax calculated at the statutory tax rate of the Company	(8,332	)	(2,762	)
Tax effects of:
Different tax rates available in different jurisdictions	893		537
Tax valuation allowance	10,231		3,881
Preferential tax deduction	(1,763	)	(845	)
Expenses not deductible for tax purposes	690		261
Utilization of previously unrecognized tax losses	(2	)	(97	)
Withholding tax on undistributed earnings of PRC entities	1,323		1,307
Others	(360	)	(436	)

Income tax expense	2,680		1,846

The significant components of deferred tax assets and liabilities are as follows:

	June 30, 2018		December 31, 2017


	(in US$'000)
Deferred tax assets
Tax losses	41,647		31,028
Others	1,448		1,267

Total deferred tax assets	43,095		32,295
Less: Valuation allowance	(42,414	)	(31,662	)

Deferred tax assets	681		633



Deferred tax liabilities
Undistributed earnings from PRC entities	4,937		4,332
Others	115		120

Deferred tax liabilities	5,052		4,452

	2018		2017


	(in US'000)
As at January 1	(3,819	)	(4,989	)
Utilization of previously recognized withholding tax on undistributed earnings	788		2,140
(Charged)/Credited to the consolidated statements of operations
Withholding tax on undistributed earnings of PRC entities	(1,323	)	(1,307	)
Deferred tax on amortization of intangible assets	10		9
Deferred tax on provision for assets	36		51
Exchange differences	(63	)	(96	)

As at June 30	(4,371	)	(4,192	)

The deferred tax assets and liabilities are offset when there is a legally enforceable right to set off and when the deferred income taxes relate to the same fiscal authority.

The Group recognizes interest and penalties, if any, under income tax payable on its condensed consolidated balance sheets and under other expenses in its condensed consolidated statements of operations. As at June 30, 2018 and December 31, 2017, the Group did not have any material unrecognized uncertain tax positions.

Basic (losses)/earnings per share is calculated by dividing the net (loss)/income attributable to the Company by the weighted average number of ordinary shares in issue during the period. Treasury shares held by the Trustee are excluded from the weighted average number of outstanding ordinary shares in issue for purposes of calculating basic (losses)/earnings per share.

Diluted (losses)/earnings per share is calculated by dividing net (loss)/income attributable to the Company by the weighted average number of ordinary and dilutive ordinary share equivalents outstanding during the period. Dilutive ordinary share equivalents include shares issuable upon the exercise or settlement of share option and LTIP awards issued by the Company using the treasury stock method.

For the six months ended June 30, 2018, the share options and LTIP awards issued by the Company were not included in the calculation of diluted losses per share because of their anti-dilutive effect.

The Group determines its operating segments from both business and geographic perspectives as follows:

Innovation Platform and Prescription Drugs businesses under the Commercial Platform are primarily located in the PRC. The locations for Consumer Health business under the Commercial Platform are further segregated into the PRC and Hong Kong.

The performance of the reportable segments is assessed based on three measurements: (a) losses or earnings of subsidiaries before interest income, interest expense, income tax expense and equity in earnings of equity investees, net of tax ("Adjusted (LBIT)/EBIT" or "Adjusted LBIT"), (b) equity in earnings of equity investees, net of tax and (c) operating (loss)/profit.

	Six Months Ended June 30, 2018


	Innovation Platform		Commercial Platform

	Drug R&D		Prescription Drugs	Consumer Health

	PRC		PRC	PRC	Hong Kong	Subtotal	Unallocated		Total

	(in US$'000)
Revenue from external customers	13,624		67,950	6,559	14,056	88,565	—		102,189

Adjusted (LBIT)/EBIT	(50,718	)	3,457	456	1,584	5,497	(7,619	)	(52,840	)
Interest income	26		23	7	32	62	2,701		2,789
Equity in earnings of equity investees, net of tax	(2,349	)	19,408	5,991	—	25,399	—		23,050

Operating (loss)/profit	(53,041	)	22,888	6,454	1,616	30,958	(4,918	)	(27,001	)
Interest expense	—		—	—	39	39	405		444
Income tax expense	20		813	124	264	1,201	1,459		2,680
Net (loss)/income attributable to the Company	(52,930	)	20,768	5,497	649	26,914	(6,675	)	(32,691	)
Depreciation/amortization	1,584		68	12	10	90	14		1,688
Additions to non-current assets (other than financial instrument and deferred tax assets)	1,564		5	7	14	26	5		1,595

	June 30, 2018


	Innovation Platform	Commercial Platform

	Drug R&D	Prescription Drugs	Consumer Health

	PRC	PRC	PRC	Hong Kong	Subtotal	Unallocated	Total

	(in US$'000)
Total assets	95,668	133,674	65,482	14,882	214,038	268,237	577,943
Property, plant and equipment	14,147	135	57	33	225	44	14,416
Leasehold land	1,264	—	—	—	—	—	1,264
Goodwill	—	2,949	407	—	3,356	—	3,356
Other intangible asset	—	403	—	—	403	—	403
Investments in equity investees	25,167	74,276	62,146	—	136,422	—	161,589

	Six Months Ended June 30, 2017


	Innovation Platform		Commercial Platform

	Drug R&D		Prescription Drugs	Consumer Health

	PRC		PRC	PRC		Hong Kong	Subtotal	Unallocated		Total

	(in US$'000)
Revenue from external customers	22,726		85,759	4,423		13,676	103,858	—		126,584

Adjusted (LBIT)/EBIT	(12,467	)	1,523	99		1,519	3,141	(6,846	)	(16,172	)
Interest income	19		17	5		3	25	207		251
Equity in earnings of equity investees, net of tax	(2,363	)	18,871	5,761		—	24,632	—		22,269

Operating (loss)/profit	(14,811	)	20,411	5,865		1,522	27,798	(6,639	)	6,348
Interest expense	—		—	—		32	32	785		817
Income tax expense	14		441	(179	)	243	505	1,327		1,846
Net (loss)/income attributable to the Company	(14,790	)	19,421	5,093		644	25,158	(8,686	)	1,682
Depreciation/amortization	1,232		52	6		9	67	13		1,312
Additions to non-current assets (other than financial instrument and deferred tax assets)	3,017		6	1		1	8	20		3,045

	December 31, 2017


	Innovation Platform	Commercial Platform

	Drug R&D	Prescription Drugs	Consumer Health

	PRC	PRC	PRC	Hong Kong	Subtotal	Unallocated	Total

	(in US$'000)
Total assets	63,268	122,665	58,961	13,794	195,420	339,244	597,932
Property, plant and equipment	13,917	160	61	30	251	52	14,220
Leasehold land	1,261	—	—	—	—	—	1,261
Goodwill	—	2,901	407	—	3,308	—	3,308
Other intangible asset	—	430	—	—	430	—	430
Investments in equity investees	19,512	69,417	55,308	—	124,725	—	144,237

Revenue from external customers is after elimination of inter-segment sales. The amount eliminated attributable to sales within Consumer Health business from Hong Kong to the PRC was nil and

US$708,000 for the six months ended June 30, 2018 and 2017 respectively. Sales between segments are carried out at mutually agreed terms.

There was one customer who accounted for over 10% of the Group's revenue for the six months ended June 30, 2018 and nil customers for the six months ended June 30, 2017.

Unallocated expenses mainly represent corporate expenses which include corporate employee benefit expenses and the relevant share-based compensation expenses. Unallocated assets mainly comprise cash and cash equivalents and short-term investments.

Reconciliation of net (loss)/income for the period to net cash (used in)/generated from operating activities:

	Six Months Ended June 30,


	2018		2017

	(in US$'000)
Net (loss)/income	(30,125	)	3,685
Adjustments to reconcile net (loss)/income to net cash used in/generated from operating activities
Depreciation and amortization	1,688		1,312
Share-based compensation expense—share options	2,791		664
Share-based compensation expense—LTIP	1,601		1,269
Equity in earnings of equity investees, net of tax	(23,050	)	(22,269	)
Dividends received from equity investees	23,526		42,617
Other adjustments	990		(772	)
Changes in working capital
Accounts receivable—third parties	(6,053	)	(2,699	)
Accounts receivable—related parties	1,310		1,804
Other receivables, prepayments and deposits	(3,266	)	(3,448	)
Amounts due from related parties	(194	)	71
Inventories	2,041		2,148
Accounts payable	(5,057	)	(2,875	)
Other payables, accruals and advance receipts	10,215		(4,320	)
Deferred revenue	1,490		(533	)
Amounts due to related parties	3,666		2,844
Other changes in working capital	(169	)	(76	)

Total changes in working capital	3,983		(7,084	)

Net cash (used in)/generated from operating activities	(18,596	)	19,422

From time to time, the Group may become involved in litigation relating to claims arising from the ordinary course of business. The Group believes that there are currently no claims or actions pending against the Group, the ultimate disposition of which could have a material adverse effect on the Group's results of operations, financial position or cash flows. However, litigation is subject to inherent uncertainties and the Group's view of these matters may change in the future. When an unfavorable outcome occurs, there exists the possibility of a material adverse impact on the Group's financial position and results of operations for the periods in which the unfavorable outcome occurs, and potentially in future periods.

The Group evaluated subsequent events through July 27, 2018, which is the date when the interim unaudited condensed consolidated financial statements were issued.


Investor Enquiries
Mark Lee, Senior Vice President,		+852 2121 8200
Corporate Finance & Development
U.K. & International Media Enquiries
Anthony Carlisle,		+44 7973 611 888 (Mobile)
Citigate Dewe Rogerson		anthony.carlisle@cdrconsultancy.co.uk
U.S. Based Media Enquiries
Brad Miles, Solebury Trout		+1 (917) 570 7340 (Mobile)
		bmiles@troutgroup.com
Susan Duffy, Solebury Trout		+1 (917) 499 8887 (Mobile)
		sduffy@troutgroup.com
Investor Relations
Xuan Yang, Solebury Trout		+1 (415) 971 9412 (Mobile)
		xyang@troutgroup.com
David Dible,		+44 7967 566 919 (Mobile)
Citigate Dewe Rogerson		david.dible@citigatedewerogerson.com
Panmure Gordon (UK) Limited
Richard Gray / Andrew Potts		+44 (20) 7886 2500

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

1	SAVOIR: 1L/2L c-MET-driven PRCC	Savolitinib monotherapy	Global	III	Initiated Q2 2017 Est. enrolled YE 2019
N/A	MES: PRCC epidemiology study	N/A—diagnostic	Global	N/A	Est. completed YE 2018
2	PAPMET: PRCC	Savolitinib vs. sunitinib vs. cabozantinib vs. crizotinib	US(NCI)	II	Est. enrolled YE 2019
3	CALYPSO: PRCC	Savolitinib and Imfinzi^®	UK/Spain	II	Est. enrolled YE 2018
4	CALYPSO: 2L ccRCC (VEGFR TKI refractory)	Savolitinib monotherapy	UK/Spain	II	Est. enrolled H1 2019
5	CALYPSO: 2L ccRCC (VEGFR TKI refractory)	Savolitinib and Imfinzi^®	UK/Spain	II	Est. enrolled H1 2019

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

6	TATTON: NSCLC 1^st/2^nd-gen EGFR TKI refractory	Savolitinib and Tagrisso^®	Global	Ib/II	Next trial est. start H1 2019
7	TATTON: NSCLC 3^rd-gen EGFR TKI refractory	Savolitinib and Tagrisso^®	Global	Ib/II	Next trial est. start YE 2018
8	2L NSCLC, EGFR TKI refractory	Savolitinib and Iressa^®	China	Ib/II	Next trial in discussion with partner AstraZeneca
9	1L NSCLC	Savolitinib monotherapy	China	II	Enrollment complete
10	MET Exon 14 mutation/deletion NSCLC	Savolitinib monotherapy	China	II	Registration intent. Enrolling

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

11	Gastric cancer (c-MET gene amplification) and VIKTORY (in South Korea)	Savolitinib monotherapy	China & South Korea	II	Enrolling
12	VIKTORY: Gastric cancer (c-MET over-expression)	Savolitinib and Taxotere^®	South Korea	II	Enrolling
13	VIKTORY: Gastric cancer (c-MET gene amplification)	Savolitinib and Taxotere^®	South Korea	II	Enrolling

TPP		Name, Line, Patient Focus		Therapy		Sites		Phase		Status

14		Metastatic Castration-Resistant Prostate Cancer		Savolitinib monotherapy		Canada		II		Enrolling

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

15	FRESCO: 3L CRC	Fruquintinib monotherapy	China	III	Pending NDA approval
16	FALUCA: 3L NSCLC	Fruquintinib monotherapy	China	III	Enrollment complete Top-line data YE 2018
17	1L NSCLC	Fruquintinib and Iressa^®	China	II	Enrollment complete
18	Solid tumors	Fruquintinib monotherapy	US	I	Est. complete YE 2018
19	FRUTIGA: 2L gastric cancer	Fruquintinib and Taxol^®	China	III	Initiated Oct 2017

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

20	SANET-p: Pancreatic NET	Sulfatinib monotherapy	China	III	Est. enrolled 2019
21	SANET-ep: Non-pancreatic NET	Sulfatinib monotherapy	China	III	Est. enrolled 2019
22	Pancreatic NET and BTC	Sulfatinib monotherapy	US	Ib/II	Enrolling
23	Thyroid cancer (Recurrent/refractory MTC)	Sulfatinib monotherapy	China	II	Enrollment complete
24	Thyroid cancer (RAI-refractory DTC)	Sulfatinib monotherapy	China	II	Enrollment complete
25	Chemotherapy refractory BTC	Sulfatinib monotherapy	China	II	Enrolling

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

26	EGFR-mutation NSCLC with brain metastasis	Epitinib monotherapy	China	Ib	Enrolling Ph. III start YE 2018
27	Glioblastoma	Epitinib monotherapy	China	Ib/II	Initiated March 2018

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

28	Solid tumors	Theliatinib monotherapy	China	I	Completed
29	Esophageal cancer	Theliatinib monotherapy	China	Ib	Enrolling

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

30	Immunology (healthy volunteers)	HMPL-523 monotherapy	Australia	I	Completed
31	Immunology (healthy volunteers)	HMPL-523 monotherapy	China	I	Initiating
32	Hematological cancers	HMPL-523 monotherapy	Australia	I	Enrolling
33	Lymphoma	HMPL-523 monotherapy	China	I	Enrolling

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

34	Healthy volunteers	HMPL-689 monotherapy	Australia	I	Completed
35	Lymphoma	HMPL-689 monotherapy	China	I	Initiated August 2017

TPP	Name, Line, Patient Focus	Therapy	Sites	Phase	Status

36	Solid tumors	HMPL-453 monotherapy	Australia	I	Discontinued
37	Solid tumors	HMPL-453 monotherapy	China	I	Enrolling

TPP		Name, Line, Patient Focus		Therapy		Sites		Phase		Status

38		Healthy volunteers		HMPL004-6599 monotherapy		Australia		I		Initiated April 2018

	Six Months Ended June 30, 2018		Six Months Ended June 30, 2017


	$'000
Segment operating loss—Innovation Platform	(53,041	)	(14,811	)
Less: Segment revenue from external customers—Innovation Platform	(13,624	)	(22,726	)

Adjusted R&D expenses	(66,665	)	(37,537	)

	Six Months Ended June 30, 2018	Six Months Ended June 30, 2017


	$'000
Consolidated operating profit—Commercial Platform	30,958	27,798
Less: One-time gains from R&D-related subsidies	—	(2,494	)

Adjusted consolidated operating profit—Commercial Platform	30,958	25,304

	Six Months Ended June 30, 2018	Six Months Ended June 30, 2017


	$'000
Consolidated net income attributable to Chi-Med—Commercial Platform	26,914	25,158
Less: One-time gains from R&D-related subsidies	—	(2,494	)

Adjusted consolidated net income attributable to Chi-Med—Commercial Platform	26,914	22,664

	Six Months Ended June 30, 2018	Six Months Ended June 30, 2017


	$'000
HBYS revenue	118,983	123,408
Less: Guanbao revenue	—	(28,964	)

Adjusted revenue of HBYS	118,983	94,444
SHPL revenue	152,717	129,718

Adjusted revenues of non-consolidated joint ventures	271,700	224,162

	June 30, 2018	December 31, 2017


	(in US$'000)
Bank deposits maturing over three months (note)
Denominated in:
US$	246,791	272,659
HK$	374	372

	247,165	273,031

	June 30, 2018		December 31, 2017


	(in US$'000)
Accounts receivable, gross	44,722		38,668
Allowance for doubtful accounts	(303	)	(258	)

Accounts receivable, net	44,419		38,410

	2018		2017


	(in US$'000)
As at January 1	258		2,720
Increase in allowance for doubtful accounts	279		6
Decrease in allowance due to subsequent collection	(235	)	(7	)
Write-off	(1	)	—
Exchange difference	2		48

As at June 30	303		2,767

	June 30, 2018	December 31, 2017


	(in US$'000)
Prepayments	4,961	2,565
Purchase rebates	184	284
Other service receivables	—	490
Deposits	1,326	932
Value-added tax receivables	6,595	5,436
Interest receivables	634	506
Others	615	1,083

	14,315	11,296

	June 30, 2018	December 31, 2017


	(in US$'000)
Raw materials	639	314
Finished goods	9,149	11,475

	9,788	11,789

	2018		2017


	(in US$'000)
As at January 1	121		160
Increase in provision for excess and obsolete inventories	79		—
Decrease in provision due to subsequent sale or recovery	(124	)	(13	)
Exchange difference	3		3

As at June 30	79		150

	June 30, 2018	December 31, 2017


	(in US$'000)
Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited ("HBYS")	62,146	55,308
Shanghai Hutchison Pharmaceuticals Limited ("SHPL")	74,276	69,417
Nutrition Science Partners Limited ("NSPL")	24,792	19,201
Other	375	311

	161,589	144,237

	June 30, 2018	December 31, 2017


	(in US$'000)
Not later than 1 year	1,272	1,282
Between 1 to 2 years	595	400
Between 2 to 3 years	391	151
Between 3 to 4 years	137	141
Between 4 to 5 years	—	47

Total minimum lease payments	2,395	2,021

	June 30, 2018	December 31, 2017


	(in US$'000)
Property, plant and equipment
Contracted but not provided for	1,368	1,034

	June 30, 2018	December 31, 2017


	(in US$'000)
Accounts payable—third parties	13,430	17,095
Accounts payable—non-controlling shareholders of subsidiaries (Note 18 (iv))	5,878	7,250
Accounts payable—related party (Note 18 (ii))	—	20

	19,308	24,365

	June 30, 2018	December 31, 2017


	(in US$'000)
Current	—	29,987
Non-current	26,692	—

	26,692	29,987

	June 30, 2018	December 31, 2017


	(in US$'000)
Not later than 1 year	3,544	3,330
Between 1 to 2 years	2,725	2,875
Between 2 to 3 years	1,232	2,132
Between 3 to 4 years	285	345
Between 4 to 5 years	52	161
Later than 5 years	4	17

Total minimum lease payments	7,842	8,860

	2018	2017


As at January 1	66,447	60,706
Share option exercises	86	31

As at June 30	66,533	60,737

	Number of treasury shares		Cost in US$'000


As at January 1, 2017	62,921		2,390
Purchased	35,095		1,367
Vested	(42,038	)	(1,800	)

As at December 31, 2017	55,978		1,957
Purchased	79,500		5,451
Vested	(23,375	)	(731	)

As at June 30, 2018	112,103		6,677

	Six Months Ended June 30, 2018


	Innovation Platform	Commercial Platform	Total

	(in US$'000)
Customers
Third parties	8,548	85,116	93,664
Related parties (Note 18 (i))	5,076	3,449	8,525

	13,624	88,565	102,189



Major product lines (note)
Goods	—	82,912	82,912
Services	13,624	5,653	19,277

	13,624	88,565	102,189

	June 30, 2018		December 31, 2017


	(in US$'000)
Innovation Platform
Receivables—included in accounts receivable	6,483		6,535
Deferred revenue—current portion (note (a))	(1,999	)	(1,295	)
Deferred revenue—noncurrent portion (note (a))	(924	)	(809	)



Commercial Platform
Receivables—included in accounts receivable	40,486		35,735
Deferred revenue—current portion (note (b))	(1,754	)	—

		(in US$'000)


Upfront payment		6,500
Development milestone payments achieved as at June 30, 2018		25,000
Remaining development and regulatory approval milestone payments		55,000

		86,500

	ASC 605			ASC 606


	December 31, 2017	Opening Adjustments		January 1, 2018

Cumulative amounts recognized to accumulated losses from:
Upfront payment (note (a))	5.7	0.5		6.2
Milestone payments (note (b))	23.7	(0.4	)	23.3

	29.4	0.1		29.5