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Income Taxes (Details 1)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Income Taxes    
Federal income tax 21.00% 21.00%
State income taxes, less federal benefit 6.39% 7.12%
Tax credits 5.57% 2.03%
Permanent differences (2.45%) (1.97%)
Change in valuation allowances (32.58%) (27.47%)
Other 2.06% 0.71%
Effective tax rate benefit (expense) (0.01%) 0.00%