Leases - Additional Information (Details)	12 Months Ended
	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	May 31, 2022 USD ($)	May 03, 2022 USD ($)	Mar. 28, 2022 USD ($) ft²
Lessee, Lease, Description [Line Items]
Operating Lease, Right-of-Use Asset	$ 9,202,670	$ 9,809,876
Operating Lease, Liability	9,317,786
Operating Lease, Liability, Current	3,300,173	4,931,675
Operating Lease, Liability, Noncurrent	6,017,613	5,121,179
Operating Leases, Rent Expense, Net	4,182,000	4,963,000
Finance Lease, Interest Expense	626,000
Gain On Right Of Use Asset Termination	276,633	$ 0
License Agreement Terms [Member]
Lessee, Lease, Description [Line Items]
Operating Lease, Right-of-Use Asset	9,056,000
Operating Lease, Liability	$ 9,056,000
Operating lease, weighted average discount rate	8.00%
Security Deposit Liability				$ 225,760
License monthly rental rate first year					$ 200,700
License monthly rental rate second year					208,728
License monthly rental rate third year					217,077
License monthly rental rate remainder of the term				200,700	$ 225,760
Increase in security deposit				235,884
License monthly rental rate				$ 209,700
ASU 2016-02
Lessee, Lease, Description [Line Items]
Lease term		3 years 3 months 14 days
Operating Lease, Right-of-Use Asset	$ 9,809,876
Operating Lease, Liability, Current	3,300,000	$ 4,931,675
Operating Lease, Liability, Noncurrent	6,018,000
Cambridge, Massachusetts
Lessee, Lease, Description [Line Items]
Office space for lease | ft²					13,000
Operating Lease Agreement
Lessee, Lease, Description [Line Items]
Operating Lease, Liability		5,121,179
Additional Laboratory Lease Fourth Amendment Member
Lessee, Lease, Description [Line Items]
Loss on Right Of Use Asset	258,000
Adjustment related to right of use asset	8,124,000
Adjustment related to lease liability	8,382,000
Lab Space Lease [Member]
Lessee, Lease, Description [Line Items]
Operating Lease, Right-of-Use Asset	945,000
Operating Lease, Cost	963,000
Gain On Right Of Use Asset Termination	19,000
First Amendment [Member] | License Agreement Terms [Member]
Lessee, Lease, Description [Line Items]
Operating Lease, Right-of-Use Asset	369,000
Operating Lease, Liability, Current	100,300
Operating Lease, Liability, Noncurrent	260,600
Operating Lease Agreement For Additional Laboratory Space [Member] | Boston [Member]
Lessee, Lease, Description [Line Items]
Operating Lease, Right-of-Use Asset	$ 1,307,000
Lessee operating lease monthly rental payments for remaining term			$ 61,519
Lessee Operating Lease Monthly Rental Payments			$ 59,152
Operating lease, weighted average discount rate	10.00%
Operating Lease, Liability, Current	$ 712,000
Operating Lease, Liability, Noncurrent	535,000
Forty G Office and Additional Laboratory [Member]
Lessee, Lease, Description [Line Items]
Security Deposit Liability	794,000	$ 794,000
Forty G Office and Additional Laboratory [Member] | ASU 2016-02
Lessee, Lease, Description [Line Items]
Operating Lease, Right-of-Use Asset	9,203,000
Twenty One Erie Laboratory and Office Lease [Member]
Lessee, Lease, Description [Line Items]
Lease Cash Collected	$ 803,000