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Non-refundable up-front license fee amount.

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Operating lease commitments.

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Regulatory and commercial milestone payments.

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Carrying value of amounts transferred to third parties for security purposes that are expected to be returned or applied towards payment in the future.

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Amount of operating lease expense. Excludes sublease income.

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Minimum amount of purchase arrangement in which the entity has agreed to expend funds to procure goods or services from a supplier.

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Commitments and contingent liabilities - Additional Information (Details) € in Thousands, $ in Thousands		12 Months Ended
	Sep. 10, 2018 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2023 EUR (€)
Loss Contingencies [Line Items]
Lease and rental expense		$ 8,196	$ 7,108	$ 7,349
Pledged bank deposits		2,848	2,296
Operating lease commitments		3,216	2,459
Debt securities, pledge to a bank as guarantee		910,616	$ 969,425
Purchase obligation		43,075
Zai License and Collaboration Agreement
Loss Contingencies [Line Items]
Non-refundable up-front license fee, amount	$ 15,000
Maximum \| Zai License and Collaboration Agreement
Loss Contingencies [Line Items]
Regulatory and commercial milestone payments	$ 78,000
Minimum \| Zai License and Collaboration Agreement \| License
Loss Contingencies [Line Items]
Percentage of tiered royalties rates on net sales	10.00%
Asset Pledged as Collateral
Loss Contingencies [Line Items]
Debt securities, pledge to a bank as guarantee		$ 16,650			€ 15,000