Income taxes (Tables)

12 Months Ended

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Schedule of Income (Loss) before Income Taxes

Income (loss) before income taxes is as follows:

	Year ended December 31,
	2023		2022		2021
Swiss	$	(281,685)	$	(269,621)	$	(145,591)
Non-Swiss	89,945		187,775		93,516
Total income (loss) before income taxes	$	(191,740)	$	(81,846)	$	(52,075)

Schedule of Components of Income Tax Expense (Benefit)

The provision (benefit) for income taxes from continuing operations is comprised of:

	Year ended December 31,
	2023		2022		2021
Current:
Swiss	$	2,163	$	469	$	281
Non-Swiss	13,140		10,219		5,995
Total current	$	15,303	$	10,688	$	6,276
Deferred:
Swiss	$	—	—		$	—
Non-Swiss	—		—		—
Total deferred	—		—		—
Total income tax provision	$	15,303	$	10,688	$	6,276

Reconciliation of Provision for Income Taxes

A reconciliation of the provision for income taxes compared with the amounts at the Swiss rate was:

	Year ended December 31,
	2023			2022			2021
Income (loss) before income taxes	$	(191,740)		$	(81,846)		$	(52,075)
Swiss federal statutory rate	8.5		%	8.5		%	8.5		%
Income tax at federal Swiss rate	$	(16,298)		$	(6,957)		$	(4,426)
Change in valuation allowance	13,427			(14,238)			11,643
Foreign taxes rate differential	10,620			25,716			1,601
Return to provision true-ups	10,854			(1,020)			2,416
Research and development credits	(6,483)			(4,898)			(2,216)
Share based compensation	2,332			5,318			(4,636)
Withholding Taxes	435			548			273
Effect of tax law change	6			5,681			—
Other	410			538			1,621
Income tax	$	15,303		$	10,688		$	6,276
Effective tax rate	(8.0)		%	(13.1)		%	(12.1)		%

Schedule of Significant Components of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets and liabilities are as follows:

	December 31,
	2023		2022
Deferred tax assets:
Unamortized intangible assets	$	153,450	$	153,450
Net operating loss carryforwards	$	99,743	$	65,472
Impact of revenue recognition	$	79,934	$	82,972
Share based compensation	$	32,639	$	30,009
Lease liabilities	$	8,128	$	5,846
Capitalized research and development	$	2,783	$	16,730
Research and development credits	$	1,615	$	8,992
Other temporary differences	$	7,809	$	7,089
Total gross deferred tax assets	$	386,101	$	370,560
Less: valuation allowance	(375,375)		(361,358)
Total deferred tax assets	10,726		9,202
Deferred tax liabilities:
Right of use assets	7,962		5,785
Fixed assets	1,914		1,730
Other liabilities	850		1,687
Total gross deferred tax liabilities	$	10,726	$	9,202
Net deferred taxes assets (liability)	$	—	$	—

Schedule of Reconciliation of Beginning and Ending Amount of Unrecognized Tax Benefits

A reconciliation of the beginning and ending balances of uncertain tax benefits is as follows:

	December 31,
	2023		2022		2021
Balance at beginning of the year	$	76	$	154	$	297
Additions (reductions) for taxes positions related to prior years	(58)		(78)		(143)
Balance at the end of the year	$	18	$	76	$	154