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Commitments and Contingent Liabilities - Additional Information (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Jan. 01, 2019
Sep. 10, 2018
Feb. 28, 2019
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Loss Contingencies [Line Items]                                    
Right-of-use assets obtained in exchange for lease liabilities                               $ 22,943    
Lease and rental expense                               4,607 $ 4,033 $ 3,474
Pledged bank deposits       $ 1,557       $ 1,143               1,557 1,143  
Operating lease commitments       1,390       1,299               1,390 1,299  
Net revenues       $ 99,234 $ 92,062 $ 86,713 $ 73,309 69,674 $ 64,756 $ 61,514 $ 52,125 $ 53,661 $ 50,109 $ 38,376 $ 34,880 351,318 248,069 $ 177,026
Zai License and Collaboration Agreement                                    
Loss Contingencies [Line Items]                                    
Non-refundable up-front license fee, amount   $ 15,000                                
License fees received               $ 12,700                    
Settlement Agreement                                    
Loss Contingencies [Line Items]                                    
Settlement expense                     $ 5,500              
Net revenues                                 250,000  
Pending Litigation | Paz Litigation                                    
Loss Contingencies [Line Items]                                    
Damages sought (in shares)     1,200,000                              
Maximum | Zai License and Collaboration Agreement                                    
Loss Contingencies [Line Items]                                    
Regulatory and commercial milestone payments   $ 78,000                                
Minimum | Zai License and Collaboration Agreement | License                                    
Loss Contingencies [Line Items]                                    
Percentage of tiered royalties rates on net sales   10.00%                                
Accounting Standards Update 2016-02                                    
Loss Contingencies [Line Items]                                    
Right-of-use assets obtained in exchange for lease liabilities $ 15,733                                  
Accounting Standards Update 2014-09 | Zai License and Collaboration Agreement | License                                    
Loss Contingencies [Line Items]                                    
Liability, revenue recognized                               $ 2,115 $ 767  
Accounting Standards Update 2014-09 | Zai License and Collaboration Agreement | License | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2020-01-01                                    
Loss Contingencies [Line Items]                                    
Revenue recognition period       6 years                       6 years