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Share Capital - Additional Information (Details) - USD ($)
1 Months Ended 12 Months Ended
Dec. 31, 2015
Oct. 07, 2015
Mar. 31, 2015
Feb. 28, 2015
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Aug. 31, 2015
Share Capital [Line Items]                
Convertible preferred shares conversion ratio         100.00%      
Voting rights of ordinary shareholder         one      
Settlement agreement date         February 2015      
Common stock, shares issued 83,778,581       83,778,581 13,431,414    
Share-based Compensation Cost       $ 0        
Warrants issued to purchase of preferred shares         975,644      
Exercise price per share $ 18.77       $ 18.77      
Class of Warrant or Right, Date from which Warrants or Rights Exercisable         Jan. 31, 2016      
Unrecognized compensation cost $ 25,008,000       $ 25,008,000      
Unrecognized compensation cost expected recognition weighted average period         3 years 4 months 21 days      
Weighted average grant date fair values options granted         $ 10.64 $ 5.08 $ 4.59  
Weighted average grant date fair values options unvested         $ 8.66 $ 4.26 $ 3.42  
Weighted average grant date fair values options unvested amount 4,613,423       4,613,423 2,934,974 3,125,543  
Weighted average grant date fair values options vested         $ 3.66 $ 2.89 $ 2.26  
Weighted average grant date fair values options vested amount         1,235,880 1,166,974 1,030,933  
Weighted average grant date fair values options forfeited and cancelled         $ 5.73 $ 3.59 $ 1.84  
Aggregate intrinsic values options exercised         $ 3,546,000 $ 3,339,000 $ 3,431,000  
Fair value of ordinary shares $ 22.36       $ 22.36 $ 7.73 $ 7.28  
2003 Plan                
Share Capital [Line Items]                
Option granted vesting period         4 years      
Option granted expiration period         10 years      
2013 Plan                
Share Capital [Line Items]                
Option granted vesting period         4 years      
Option granted expiration period         10 years      
Increase in shares authorized for issuance available for grants     13,198,224 2,956,500        
Ordinary shares available for grants 0       0      
2015 Plan                
Share Capital [Line Items]                
Option granted vesting period         4 years      
Option granted expiration period         10 years      
Increase in shares authorized for issuance available for grants 16,251,143       16,251,143     12,900,000
Ordinary shares available for grants 14,947,667       14,947,667      
Percentage increase in number of shares available for issuance 4.00%              
Condition One                
Share Capital [Line Items]                
Settlement agreement terms         (i) 18 months after signing of the Agreement, (ii) an IPO or (iii) the earlier of consummation of a merger/acquisition (“M&A”) or achievement of a Cumulative Net Sales milestone of $250,000 (as defined pursuant to the Agreement).      
Condition Two                
Share Capital [Line Items]                
Settlement agreement terms         (i) achievement of the Cumulative Net Sales milestone per above or (ii) consummation of a merger or acquisition transaction      
Settlement Agreement                
Share Capital [Line Items]                
Earlier Payment period after agreement       18 months        
Net sales milestone       $ 250,000,000        
Common stock, shares issued       1,005,210        
Ordinary shares granted       1,005,210        
Earlier Period for Option Termination       12 months        
Stock redeemed or called during period, shares       2,010,420        
Cash obligation     $ 2,000,000     $ 2,000,000    
Settlement Agreement | General and Administrative                
Share Capital [Line Items]                
Settlement expense           $ 1,867,000    
Settlement Agreement | Condition One                
Share Capital [Line Items]                
Settlement expense       $ 1,000,000        
Settlement additional payment       1,000,000        
Settlement additional amount paid       1,000,000        
Settlement Agreement | Condition Two                
Share Capital [Line Items]                
Settlement additional payment       $ 5,500,000        
Minimum                
Share Capital [Line Items]                
Entity listing value of share requirement for qualifying IPO in NYSE or NASDAQ         $ 50,000,000      
Entity listing value of share requirement for qualifying IPO in other public stock exchange.         $ 100,000,000      
Minimum | Settlement Agreement                
Share Capital [Line Items]                
Percentage of closing price per share     80.00%          
ESPP                
Share Capital [Line Items]                
Increase in shares authorized for issuance available for grants 830,000       830,000      
Ordinary shares available for grants 1,667,785       1,667,785      
Percentage of increase in shares outstanding         1.00%      
ESPP | Minimum                
Share Capital [Line Items]                
Increase in shares authorized for issuance available for grants 837,785       837,785      
ESPP | Maximum                
Share Capital [Line Items]                
Increase in shares authorized for issuance available for grants 1,667,785       1,667,785      
Ordinary Shares | IPO                
Share Capital [Line Items]                
Sale of ordinary shares   7,876,195            
Proceeds from issuance of ordinary shares   $ 157,534,000            
Series I Convertible Preferred shares                
Share Capital [Line Items]                
Shares issued 13,360,252       13,360,252      
Shares issued, price per share $ 14.53       $ 14.53      
Proceeds from issuance of preferred shares, net         $ 191,738,000      
Liquidation preference per share $ 14.53       $ 14.53      
Series J Convertible Preferred shares                
Share Capital [Line Items]                
Shares issued 4,068,500       4,068,500      
Shares issued, price per share $ 23.33       $ 23.33      
Proceeds from issuance of preferred shares, net         $ 94,599,000      
Liquidation preference per share 23.33       $ 23.33      
Share issuance expenses         $ 319,000      
Series A Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share 1.52       $ 1.52      
Series B Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share 1.09       1.09      
Series C Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share 1.77       1.77      
Series D Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share 1.80       1.80      
Series E Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share 1.80       1.80      
Series F Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share 2.23       2.23      
Series G Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share 8.64       8.64      
Series H Convertible Preferred shares                
Share Capital [Line Items]                
Liquidation preference per share $ 13.5       $ 13.5