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Organization and Business Activities (Details)
1 Months Ended 12 Months Ended
Apr. 15, 2023
USD ($)
Jan. 02, 2023
USD ($)
Sep. 30, 2021
USD ($)
$ / shares
shares
May 31, 2021
USD ($)
Mar. 31, 2021
USD ($)
$ / shares
shares
Dec. 31, 2020
USD ($)
$ / shares
shares
May 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2022
USD ($)
shares
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
$ / shares
Jul. 13, 2022
country
Dec. 31, 2019
USD ($)
Liquidity                        
Number of countries, exclusive rights are distributed. | country                     9  
Number of additional countries rights are distributed | country                     5  
Cash and cash equivalents and restricted cash           $ 41,590,000   $ 12,537,000 $ 47,834,000 $ 41,590,000   $ 86,411,000
Proceeds from at-the-market facility               3,460,000 42,280,000 7,520,000    
Shares issued               5,584,000 $ 70,138,000 $ 61,060,000    
Public offering                        
Liquidity                        
Number of shares issued | shares           240,000            
Shares Issued, Price Per Share | $ / shares           $ 62.50       $ 62.50    
Proceeds from at-the-market facility           $ 15,000,000.0            
Net proceeds from sale of stock           $ 13,300,000            
Purchase agreement                        
Liquidity                        
Number of shares issued | shares             165,755          
Proceeds from at-the-market facility             $ 38,000,000.0          
Net proceeds from sale of stock             $ 35,200,000          
Number of ordinary shares that can be purchased by warrant holders | shares             165,755          
Share and warrant price | $ / shares             $ 229.21          
Purchasers | Purchase agreement                        
Liquidity                        
Number of shares issued | shares         390,440              
Net proceeds from sale of stock         $ 23,400,000              
Proceeds from Issuance or Sale of Equity         $ 25,400,000              
Number of ordinary shares that can be purchased by warrant holders | shares         195,220              
Term         5 years              
Lincoln Park Capital Fund, LLC | Purchase agreement                        
Liquidity                        
Net proceeds from sale of stock               $ 4,600,000        
Lincoln Park Capital Fund, LLC | Purchase agreement | Maximum                        
Liquidity                        
Ordinary shares remained unsold   $ 18,500,000                    
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares                        
Liquidity                        
Number of shares issued | shares               320,000        
Net proceeds from sale of stock               $ 4,600,000        
Commitment shares | shares     25,298                  
Commitment share price | $ / shares     $ 0.01                  
Regular purchase     $ 2,500,000                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Minimum                        
Liquidity                        
Shares issued     200,000                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Maximum                        
Liquidity                        
Shares issued     $ 23,000,000.0                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Share Price Not Below $0.25 Per Share                        
Liquidity                        
Share price | $ / shares     $ 0.25                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Share Price Not Below $0.25 Per Share | Maximum                        
Liquidity                        
Number of shares issued | shares     16,000                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Share Price Not Below $2.00 Per Share                        
Liquidity                        
Share price | $ / shares     $ 50.00                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Share Price Not Below $2.00 Per Share | Maximum                        
Liquidity                        
Number of shares issued | shares     24,000                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Share Price Not Below $3.00 Per Share                        
Liquidity                        
Share price | $ / shares     $ 75.00                  
Lincoln Park Capital Fund, LLC | Purchase agreement | Ordinary shares | Share Price Not Below $3.00 Per Share | Maximum                        
Liquidity                        
Number of shares issued | shares     32,000                  
Ordinary Share Warrants | Purchasers | Purchase agreement                        
Liquidity                        
Number of ordinary shares that can be purchased by warrant holders | shares         24,000              
Share and warrant price | $ / shares         $ 61.31              
Exercise price | $ / shares         $ 59.75              
Pre-Funded Warrants | Purchasers | Purchase agreement                        
Liquidity                        
Number of ordinary shares that can be purchased by warrant holders | shares         12,000              
Share and warrant price | $ / shares         $ 61.06              
Exercise price | $ / shares         $ 0.01              
Open Market Sale Agreement | Jefferies LLC | Ordinary shares                        
Liquidity                        
Number of shares issued | shares               1,429,729        
Proceeds from at-the-market facility               $ 32,500,000        
Aggregate gross sale proceeds for ordinary shares               $ 33,900,000        
Open Market Sale Agreement | Jefferies LLC | Ordinary shares | Maximum                        
Liquidity                        
Aggregate gross sale proceeds for ordinary shares       $ 50,000,000.0                
Subsequent Event | Lincoln Park Capital Fund, LLC | Purchase agreement | Maximum                        
Liquidity                        
Ordinary shares remained unsold $ 18,500,000