Number of vesting periods

No definition available.

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- Definition

Percentage of vesting of share-based compensation awards that vests monthly during the vesting period.

+ References

No definition available.

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- Definition

It represents the period of monthly vesting of share-based compensation awards.

+ References

No definition available.

+ Details

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

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- Definition

Aggregate number of common shares reserved for future issuance.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.29)
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- Definition

Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)(1)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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- Definition

The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

+ References

+ Details

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

Gross number of share options (or share units) granted during the period.

+ References

+ Details

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- Definition

Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
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-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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- Definition

Description of terms of award under share-based payment arrangement.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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- Definition

Percentage of vesting of award under share-based payment arrangement.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)(1)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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- Definition

Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)(2)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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Share-Based Payments - Stock Plan Activity (Details) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended		12 Months Ended
	Jul. 31, 2018 $ / shares shares	Sep. 30, 2022 USD ($) $ / shares shares	Sep. 30, 2021 USD ($) shares	Sep. 30, 2022 USD ($) $ / shares shares	Sep. 30, 2021 USD ($) shares	Dec. 31, 2020 tranche	Dec. 31, 2018	Dec. 31, 2021 $ / shares	Aug. 31, 2021 shares	Dec. 09, 2020 shares	Mar. 04, 2020 shares	Mar. 12, 2019 shares
Share-Based Payments
Share-based compensation expense \| $		$ 498	$ 779	$ 1,832	$ 2,517
Stock Options
Share-Based Payments
Options granted during the period				24,160
Options exercise price (in dollars per share) \| $ / shares		$ 349.79		$ 349.79				$ 510.34
Restricted Share Units ("RSUs")
Share-Based Payments
Restricted stock granted during the period				19,566
Stock Option Plan 2015 \| Stock Options
Share-Based Payments
Vesting period				4 years
Stock Option Plan 2015 \| Stock Options \| Vesting period, year one
Share-Based Payments
Percentage that vests during the period				25.00%
Stock Option Plan 2015 \| Stock Options \| Vesting period, years 2-4
Share-Based Payments
Percentage that vests during the period				75.00%
Monthly vesting percentage				2.083%
Stock Option Plan 2015 \| Maximum \| Stock Options
Share-Based Payments
Exercise period				10 years
2017 Share Incentive Plan \| Restricted Share Units ("RSUs")
Share-Based Payments
Vesting period				4 years
Percentage that vests during the period				25.00%
2017 Share Incentive Plan \| Restricted Share Units ("RSUs") \| Immediate vesting upon regulatory approval \| CONTEPO
Share-Based Payments
Percentage that vests during the period							50.00%
2017 Share Incentive Plan \| Restricted Share Units ("RSUs") \| Vesting upon the one-year-anniversary of FDA approval \| CONTEPO
Share-Based Payments
Percentage that vests during the period							50.00%
2019 Inducement Plan \| Ordinary shares
Share-Based Payments
Shares reserved for future issuance												8,000
Inducement Awards Outside of the 2019 Inducement Plan \| Vesting period, year one
Share-Based Payments
Percentage that vests during the period	25.00%
Inducement Awards Outside of the 2019 Inducement Plan \| Vesting period, year two
Share-Based Payments
Percentage that vests during the period	75.00%
Monthly vesting period	36 months
Inducement Awards Outside of the 2019 Inducement Plan \| Non-statutory option
Share-Based Payments
Vesting period	4 years
Exercise period	10 years
Options exercise price (in dollars per share) \| $ / shares	$ 882.50
Inducement Awards Outside of the 2019 Inducement Plan \| Non-statutory option \| Chief Executive Officer
Share-Based Payments
Options granted during the period	3,400
2020 Share Incentive Plan \| Stock Options
Share-Based Payments
Options granted during the period				23,680
Options exercise price (in dollars per share) \| $ / shares		$ 11.25		$ 11.25
Share-based compensation expense \| $				$ 66
2020 Share Incentive Plan \| Restricted Share Units ("RSUs")
Share-Based Payments
Restricted stock granted during the period				11,836
2020 Share Incentive Plan \| Restricted Share Units ("RSUs") \| Chief Executive Officer
Share-Based Payments
Percentage that vests during the period				50.00%
Restricted stock granted during the period				280
2020 Share Incentive Plan \| Restricted Share Units ("RSUs") \| Employees
Share-Based Payments
Vesting period						6 months
Percentage that vests during the period						25.00%
Number of vesting periods \| tranche						3
2020 Share Incentive Plan \| Ordinary shares
Share-Based Payments
Shares reserved for future issuance		9,885		9,885
2020 Share Incentive Plan \| Ordinary shares \| Maximum
Share-Based Payments
Shares reserved for future issuance											37,200
2021 Inducement Share Incentive Plan \| Maximum
Share-Based Payments
Term of Awards				ten years
2021 Inducement Share Incentive Plan \| Ordinary shares
Share-Based Payments
Shares reserved for future issuance			20,000		20,000				8,000	8,000