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Share-Based Payments (Tables)
9 Months Ended
Sep. 30, 2022
Share-Based Payments  
Summary of information regarding stock option awards

Weighted

Weighted

Average

average

Remaining

Aggregate

exercise

Contractual

intrinsic

price in

Term

value

Options

$ per share

(in years)

(in thousands)

Outstanding as of January 1, 2022

53,885

$

510.34

8.0

Granted

24,160

11.25

Exercised

Cancelled and forfeited

(500)

816.81

Outstanding as of September 30, 2022

77,545

$

349.79

7.9

$

Vested and exercisable as of September 30, 2022

36,829

$

685.59

6.7

$

Summary of assumptions used for valuation of options

    

Expected volatility

 

76.4% - 76.9%

Expected term of options (in years)

 

6.1

Range of risk-free interest rate

 

1.68% - 1.76%

Dividend yield

 

Summary of information regarding restricted stock awards

Weighted

average fair

RSUs

value in $ per share

Outstanding as of January 1, 2022

31,538

$

74.10

Granted

19,566

11.04

Vested and issued

(9,222)

76.37

Forfeited

(1,042)

46.69

Outstanding as of September 30, 2022

40,840

$

44.07

Schedule of allocation of share-based compensation expense

Three Months Ended

Nine Months Ended

September 30, 

September 30, 

(in thousands)

    

2022

    

2021

2022

    

2021

Research and development expense

 

$

63

$

96

$

224

$

435

Selling, general and administrative expense

 

435

683

1,608

2,082

Total stock-based compensation expense

 

$

498

$

779

$

1,832

$

2,517