percentage of annual minimum purchase requirement reduction.

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- Definition

Percentage of annual minimum purchase requirement reduction in year four.

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Percentage of annual minimum purchase requirement reduction in year one to three.

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- Definition

Cash payments made for amendment of agreement.

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The amount of milestone payment receivable in cash upon marketing approval by the FDA with respect to any oral, intravenous or other form of fosfomycin by the company prior to acquisition.

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Royalty payments to be paid.

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Threshold aggregate royalty payments that required the company to repay the difference amount at the end of royalty term.

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- Definition

The amount of threshold milestone payment that may be settled in ordinary shares in the aggregate upon the occurrence of various specified levels of net sales with respect to the Zavante Products, prior to acquisition.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Amount of liability recognized arising from contingent consideration in a business combination.

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Amount of loss contingency liability.

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Commitments and Contingencies (Details) € in Millions, $ in Millions		12 Months Ended
	Aug. 04, 2021 EUR (€)	Dec. 31, 2021 USD ($)	Jul. 31, 2018 USD ($)
Other Commitments and Contingencies
Contingent liabilities		$ 0.0
Zavante Therapeutics
Acquisition of Zavante
Milestone payment receivable prior acquisition			$ 3.0
Threshold milestone payment that may be settled in ordinary shares			26.0
Zavante Therapeutics \| Maximum
Acquisition of Zavante
Contingent consideration			97.5
Hovione Supply Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Cash payments made for amendment of agreement \| €	€ 3.2
Threshold aggregate royalty payments \| €	4.0
Acquisition of Zavante
Percentage of annual minimum purchase requirement reduction in 2021		0.00%
Percentage of annual minimum purchase requirement reduction 2022 to 2024		50.00%
Percentage of annual minimum purchase requirement reduction in 2025		25.00%
Hovione Supply Agreement [Member] \| Maximum
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty payment \| €	€ 10.0
Approval Milestone Payment \| Zavante Therapeutics
Acquisition of Zavante
Contingent consideration			25.0
Net Sales Milestone Payments \| Zavante Therapeutics
Acquisition of Zavante
Contingent consideration			$ 72.5