Income Tax Expense - Net Operating Losses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Net operating losses carryforwards
Period in which the company is in cumulative loss position.	3 years
Valuation allowance	$ 118,583	$ 116,200	$ 103,185	$ 100,832
Uncertain tax positions disclosures
Uncertain tax positions	0
Decrease in research tax credit	100
Ireland
Net operating losses carryforwards
Net operating losses carryforwards	297,453
Austria
Net operating losses carryforwards
Net operating losses carryforwards	239,510
U.S.
Net operating losses carryforwards
Net operating losses carryforwards	10,403
Net operating losses carryforwards	$ 35,516