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Share-Based Payments - Stock Options (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Fair Value Assumptions      
Dividend yield 0.00% 0.00% 0.00%
Minimum      
Fair Value Assumptions      
Expected volatility 75.30% 63.70% 59.80%
Expected term of options (in years) 5 years 6 months 5 years 6 months 6 years
Range of risk-free interest rate 0.80% 0.80% 1.90%
Maximum      
Fair Value Assumptions      
Expected volatility 77.30% 74.40% 63.10%
Expected term of options (in years) 6 years 1 month 6 days 6 years 1 month 6 days 6 years 1 month 6 days
Range of risk-free interest rate 1.30% 1.50% 3.00%
Stock Options      
Options      
Outstanding at beginning of year (in shares) 1,052,838 816,891 609,133
Granted (in shares) 637,880 465,055 316,645
Forfeited (in shares) (342,241) (229,108) (108,887)
Outstanding at end of year (in shares) 1,348,477 1,052,838 816,891
Vested and exercisable at end of year (in shares) 533,564    
Weighted average exercise price in $ per share      
Outstanding balance at beginning of year (in dollars per share) $ 35.08 $ 47.82 $ 65.17
Granted (in dollars per share) 1.23 11.27 20.11
Forfeited (in dollars per share) 16.90 31.92 64.33
Outstanding balance at end of year (in dollars per share) 20.46 35.08 47.82
Vested and exercisable balance at end of year (in dollars per share) $ 45.05    
Weighted Average Remaining Contractual Term (in years)      
Weighted average remaining contractual term, outstanding 8 years    
Weighted average remaining contractual term, vested and exercisable 6 years 8 months 12 days    
Additional disclosures      
Total unrecognized compensation related to unvested options $ 1.8    
Recognition period 10 months 24 days    
Weighted-average grant date fair value (in dollars per share) $ 0.82 $ 5.99 $ 11.95
Stock Options | Exercise Price Range From 1.06 To 110.0 [Member]      
Additional disclosures      
Exercise price maximum range 110.00    
Exercise price minimum range $ 1.06    
Stock Options | Minimum      
Fair Value Assumptions      
Risk-free interest rate average market yield term 5 years    
Stock Options | Maximum      
Fair Value Assumptions      
Risk-free interest rate average market yield term 7 years