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Share-Based Payments - Stock Plan Activity (Details)
1 Months Ended 12 Months Ended
Jul. 31, 2018
$ / shares
shares
Dec. 31, 2021
$ / shares
shares
Dec. 31, 2020
tranche
$ / shares
shares
Dec. 31, 2019
$ / shares
shares
Dec. 31, 2018
tranche
$ / shares
Sep. 30, 2021
shares
Aug. 31, 2021
shares
Mar. 04, 2021
shares
Dec. 09, 2020
shares
Mar. 12, 2019
shares
Stock Options                    
Share-Based Payments                    
Options granted during the period   637,880 465,055 316,645            
Options exercise price (in dollars per share) | $ / shares   $ 20.46 $ 35.08 $ 47.82 $ 65.17          
Restricted Share Units ("RSUs")                    
Share-Based Payments                    
Restricted stock granted during the period   769,132 244,832 47,900            
Stock Option Plan 2015 | Stock Options                    
Share-Based Payments                    
Vesting period   4 years                
Stock Option Plan 2015 | Stock Options | Vesting period, year one                    
Share-Based Payments                    
Percentage that vests during the period   25.00%                
Stock Option Plan 2015 | Stock Options | Vesting period, years 2-4                    
Share-Based Payments                    
Percentage that vests during the period   75.00%                
Monthly vesting percentage   2.083%                
Stock Option Plan 2015 | Maximum | Stock Options                    
Share-Based Payments                    
Exercise period   10 years                
2017 Share Incentive Plan | Restricted Share Units ("RSUs")                    
Share-Based Payments                    
Vesting period   4 years                
Percentage that vests during the period   25.00%                
2017 Share Incentive Plan | Restricted Share Units ("RSUs") | XENLETA                    
Share-Based Payments                    
Vesting period         6 months          
Number of vesting periods | tranche         3          
2017 Share Incentive Plan | Restricted Share Units ("RSUs") | Immediate vesting upon regulatory approval | XENLETA                    
Share-Based Payments                    
Percentage that vests during the period         50.00%          
2017 Share Incentive Plan | Restricted Share Units ("RSUs") | Immediate vesting upon regulatory approval | CONTEPO                    
Share-Based Payments                    
Percentage that vests during the period         50.00%          
2017 Share Incentive Plan | Restricted Share Units ("RSUs") | Vesting upon the one-year-anniversary of FDA approval | XENLETA                    
Share-Based Payments                    
Percentage that vests during the period         50.00%          
2017 Share Incentive Plan | Restricted Share Units ("RSUs") | Vesting upon the one-year-anniversary of FDA approval | CONTEPO                    
Share-Based Payments                    
Percentage that vests during the period         50.00%          
2019 Inducement Plan | Ordinary shares                    
Share-Based Payments                    
Shares reserved for future issuance                   200,000
Inducement Awards Outside of the 2019 Inducement Plan | Vesting period, year one                    
Share-Based Payments                    
Percentage that vests during the period 25.00%                  
Inducement Awards Outside of the 2019 Inducement Plan | Vesting period, year two                    
Share-Based Payments                    
Percentage that vests during the period 75.00%                  
Monthly vesting period 36 months                  
Inducement Awards Outside of the 2019 Inducement Plan | Restricted Share Units ("RSUs") | Chief Executive Officer                    
Share-Based Payments                    
Options granted during the period 15,000                  
Inducement Awards Outside of the 2019 Inducement Plan | Restricted Share Units ("RSUs") | Upon receipt of FDA approval                    
Share-Based Payments                    
Percentage that vests during the period 50.00%                  
Inducement Awards Outside of the 2019 Inducement Plan | Restricted Share Units ("RSUs") | First anniversary of FDA approval                    
Share-Based Payments                    
Percentage that vests during the period 50.00%                  
Inducement Awards Outside of the 2019 Inducement Plan | Non-statutory option                    
Share-Based Payments                    
Vesting period 4 years                  
Exercise period 10 years                  
Options exercise price (in dollars per share) | $ / shares $ 35.30                  
Inducement Awards Outside of the 2019 Inducement Plan | Non-statutory option | Chief Executive Officer                    
Share-Based Payments                    
Options granted during the period 85,000                  
2020 Share Incentive Plan | Restricted Share Units ("RSUs") | Chief Executive Officer                    
Share-Based Payments                    
Percentage that vests during the period   50.00%                
Restricted stock granted during the period   7,000                
2020 Share Incentive Plan | Restricted Share Units ("RSUs") | Employees                    
Share-Based Payments                    
Vesting period     6 months              
Number of vesting periods | tranche     3              
2020 Share Incentive Plan | Ordinary shares                    
Share-Based Payments                    
Shares reserved for future issuance   271,080                
2020 Share Incentive Plan | Ordinary shares | Maximum                    
Share-Based Payments                    
Shares reserved for future issuance               930,000    
2021 Inducement Share Incentive Plan | Maximum                    
Share-Based Payments                    
Term of Awards   ten years                
2021 Inducement Share Incentive Plan | Ordinary shares                    
Share-Based Payments                    
Shares reserved for future issuance           500,000 200,000   200,000