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Share-Based Payments (Tables)
12 Months Ended
Dec. 31, 2021
Share-Based Payments  
Summary of information regarding stock option awards

Weighted

Weighted

Average

average

Remaining

Aggregate

exercise

Contractual

intrinsic

price in

Term

value

Options

    

$ per share

    

(in years)

(in thousands)

Outstanding as of January 1, 2019

609,133

65.17

Granted

316,645

20.11

 

Exercised

Cancelled and forfeited

(108,887)

64.33

Outstanding as of December 31, 2019

816,891

47.82

Granted

465,055

11.27

Exercised

Cancelled and forfeited

(229,108)

31.92

Outstanding as of December 31, 2020

1,052,838

35.08

Granted

637,880

1.23

Exercised

Cancelled and forfeited

(342,241)

16.90

Outstanding as of December 31, 2021

1,348,477

 

20.46

8.0

$

Vested and exercisable as of December 31, 2021

533,564

 

45.05

6.7

$

Summary of assumptions used for valuation of options

Input parameters

    

2021

2020

2019

Range of expected volatility

 

75.3% ‑ 77.3%

63.7% ‑ 74.4%

59.8% - 63.1%

Expected term of options (in years)

 

5.5 - 6.1

5.5 - 6.1

6.0 - 6.1

Range of risk-free interest rate

 

0.8% ‑ 1.3%

0.8% ‑ 1.5%

1.9% - 3.0%

Dividend yield

 

Schedule of allocation of share-based compensation expense

Year Ended

December 31, 

(in thousands)

    

2021

    

2020

    

2019

Research and development expense

 

$

565

$

1,280

$

2,138

Selling, general and administrative expense

 

2,726

3,939

7,610

Total stock-based compensation expense

 

$

3,291

$

5,219

$

9,748

2017 Share Incentive Plan  
Share-Based Payments  
Summary of information regarding restricted stock awards

Weighted average

grant date fair

RSUs

value in $ per share

Outstanding as of January 1, 2019

137,210

33.34

Granted

47,900

19.00

Vested and issued

(65,758)

31.80

Forfeited

(14,183)

27.87

Outstanding as of December 31, 2019

105,169

28.50

Granted

244,832

10.99

Vested and issued

(52,640)

31.15

Forfeited

(57,977)

21.74

Outstanding as of December 31, 2020

239,384

11.60

Granted

769,132

2.02

Vested and issued

(90,330)

12.04

Forfeited

(128,448)

6.93

Outstanding as of December 31, 2021

789,738

2.92