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Debt - Summary (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended
Jun. 02, 2021
Mar. 11, 2020
Feb. 29, 2020
Mar. 31, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Dec. 31, 2018
Debt                
Loss on extinguishment of debt           $ (2,757,000)    
Term loan                
Debt                
End of term fee         $ 5,000,000   $ 5,000,000  
Loan Agreement | Term loan                
Debt                
Maximum borrowing capacity               $ 75,000,000.0
Principal amount of advances outstanding   $ 35,000,000.0            
Interest rate (as a percent)         9.80%      
Fee due at maturity, as a percentage of aggregate advances         6.95%      
The amount in excess of which prepayments may be made         $ 5,000,000.0      
Repayment of debt   $ 30,000,000.0     30,000,000.0      
Minimum cash and cash equivalents in accounts to be maintained $ 3,000,000.0              
Net product revenue $ 15,000,000.0              
Trailing period 3 months   6 months          
Percent of net product revenue sales target   70.00% 80.00%          
Minimum liquidity requirement     $ 40,000,000.0          
Minimum amount to be maintained in cash and cash equivalents   $ 3,000,000.0            
Maximum value of lender option to purchase equity securities         2,000,000.0      
End of term loan charge payment   2,100,000            
End of term loan charge   $ 300,000 $ 600,000          
Loan origination costs         1,300,000      
Initial fee paid to lender         700,000      
Loss on extinguishment of debt       $ 2,700,000        
End of term fee         $ 5,000,000.0      
Loan Agreement | Term loan | Prime rate                
Debt                
Variable rate basis         interest minus 5.50%      
Variable interest rate margin (as a percent)         9.80%      
Variable rate adjustment (as a percent)         5.50%      
Loan Agreement | Term loan | Initial Advance                
Debt                
Principal amount of advances outstanding               25,000,000.0
Loan Agreement | Term loan | Tranche 7 Advance                
Debt                
Maximum borrowing capacity               $ 5,000,000.0
Additional tranches         $ 5,000,000.0      
Loan Agreement | Term loan | Prepayment during the first 12 months following initial closing                
Debt                
Prepayment penalty as a percentage of the amount being repaid         3.00%      
Loan Agreement | Term loan | Prepayment after the first 12 months following initial closing but before 24 months                
Debt                
Prepayment penalty as a percentage of the amount being repaid         2.00%      
Loan Agreement | Term loan | Prepayment after the first 24 months following initial closing but before maturity                
Debt                
Prepayment penalty as a percentage of the amount being repaid         1.00%