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Revenue (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2018
Dec. 31, 2020
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenue          
Revenue accounted for under Topic 606     $ 5,027 $ 9,481 $ 9,656
Product revenue, gross     500    
Sinovant Sciences, LTD | License Agreement          
Revenue          
Regulatory milestone payment received       500  
Merck & Co | License Agreement          
Revenue          
Regulatory milestone payment received     1,800    
Collaboration revenue          
Revenue          
Revenue accounted for under Topic 606     2,756 6,210 6,500
Collaboration revenue - Upfront payment          
Revenue          
Revenue accounted for under Topic 606     108 1,538  
Product revenue, gross     484 2,173  
Collaboration revenue - Upfront payment | License Agreement          
Revenue          
Revenue accounted for under Topic 606     1,000    
Collaboration revenue - Upfront payment | Sinovant Sciences, LTD | License Agreement          
Revenue          
Revenue accounted for under Topic 606 $ 5,000 $ 1,000   1,000  
Collaboration revenue - Upfront payment | Sunovion Pharmaceutics Canada, Inc.          
Revenue          
Revenue accounted for under Topic 606 $ 1,000        
Collaboration revenue - Variable consideration | Sinovant Sciences, LTD | License Agreement          
Revenue          
Milestone payment received       5,000  
Research premium          
Revenue          
Revenue accounted for under Topic 606     1,227 1,311 2,594
Government grants          
Revenue          
Revenue accounted for under Topic 606     $ 936 $ 422 $ 562