Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenues:
Total revenue	$ 5,027	$ 9,481	$ 9,656
Operating expenses:
Cost of product sales	(766)	(70)
Research and development expenses	(15,102)	(26,415)	(82,288)
Selling, general and administrative expenses	(55,285)	(62,485)	(41,743)
Total operating expenses	(71,153)	(88,970)	(124,031)
Loss from operations	(66,126)	(79,489)	(114,375)
Other income (expense):
Other income (expense), net	1,187	215	(272)
Interest income	86	255	49
Interest expense	(1,735)	(3,644)	(133)
Loss on extinguishment of debt	(2,757)
Loss before income taxes	(69,345)	(82,663)	(114,731)
Income tax expense	(139)	(101)	(49)
Net loss	$ (69,484)	$ (82,764)	$ (114,780)
Loss per share
Basic and Diluted ($ per share)	$ (5.41)	$ (11.15)	$ (22.60)
Weighted average number of shares:
Basic and Diluted	12,845,089	7,419,948	5,079,576
Product revenue, net
Revenues:
Total revenue	$ 108	$ 1,538
Collaboration revenue
Revenues:
Total revenue	2,756	6,210	$ 6,500
Research premium and grant revenue
Revenues:
Total revenue	$ 2,163	$ 1,733	$ 3,156