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Organization and Business Activities (Details)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Mar. 01, 2021
$ / shares
shares
Mar. 11, 2020
USD ($)
Jul. 31, 2018
USD ($)
$ / shares
shares
Mar. 31, 2021
USD ($)
$ / shares
shares
Jan. 31, 2021
USD ($)
shares
Dec. 31, 2020
USD ($)
$ / shares
shares
Nov. 30, 2020
employee
Sep. 30, 2020
employee
May 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
Jun. 30, 2019
USD ($)
Jun. 25, 2019
USD ($)
Liquidity                            
Cash, cash equivalents and short-term investments           $ 41,600       $ 41,600        
Selling, general and administrative expenses                   55,285 $ 62,485 $ 41,743    
Number of sales representatives | employee             60 15            
Proceeds from at-the-market facility                   $ 7,520 $ 27,945 $ 24,219    
Net proceeds from sale of stock                 $ 35,200          
Nominal value | $ / shares           $ 0.01       $ 0.01 $ 0.01      
Public offering                            
Liquidity                            
Number of shares issued | shares           6,000,000       6,000,000        
Shares Issued, Price Per Share | $ / shares           $ 2.50       $ 2.50        
Proceeds from at-the-market facility           $ 15,000       $ 15,000        
Net proceeds from sale of stock           $ 13,300       13,300        
Public offering | Ordinary Shares                            
Liquidity                            
Number of shares issued | shares     1,818,181                      
Shares Issued, Price Per Share | $ / shares     $ 27                      
Proceeds from at-the-market facility     $ 50,000                      
Net proceeds from sale of stock     $ 46,300                      
Purchase agreement                            
Liquidity                            
Number of shares issued | shares                 4,144,537          
Proceeds from at-the-market facility                 $ 38,000          
Net proceeds from sale of stock                 $ 35,200          
Number of ordinary shares that can be purchased by warrant holders | shares                 4,144,537          
Share and warrant price | $ / shares                 $ 9.1686          
Jefferies LLC | At-the-market offering                            
Liquidity                            
Maximum aggregate gross proceeds under the sales agreement                         $ 50,000 $ 50,000
Proceeds from at-the-market facility         $ 16,300         21,900        
Net proceeds from sale of stock         $ 11,500         $ 20,400        
Jefferies LLC | At-the-market offering | Ordinary Shares                            
Liquidity                            
Number of shares issued | shares         3,933,350         1,992,390        
Jefferies LLC | Estimate | At-the-market offering                            
Liquidity                            
Number of shares issued | shares         3,933,350                  
Net proceeds from sale of stock         $ 11,500                  
Jefferies LLC | Estimate | At-the-market offering | Maximum                            
Liquidity                            
Proceeds from at-the-market facility         $ 16,300                  
Purchasers | Purchase agreement                            
Liquidity                            
Number of shares issued | shares                 4,144,537   1,379,310      
Proceeds from at-the-market facility                     $ 20,000      
Net proceeds from sale of stock                     $ 18,300      
Number of ordinary shares that can be purchased by warrant holders | shares                 4,144,537   1      
Share and warrant price | $ / shares                 $ 9.1686   $ 14.50      
Exercise price | $ / shares           $ 7.92       $ 7.92        
Term           2 years       2 years        
Warrants outstanding | shares           4,059,532       4,059,532        
Loan Agreement | Term loan                            
Liquidity                            
Repayment of debt   $ 30,000               $ 30,000        
Aggregate principal amount of debt outstanding   $ 35,000                        
Subsequent Event | Purchasers | Purchase agreement                            
Liquidity                            
Number of shares issued | shares 9,761,010     9,761,010                    
Net proceeds from sale of stock       $ 23,400                    
Proceeds from Issuance or Sale of Equity       $ 25,400                    
Number of ordinary shares that can be purchased by warrant holders | shares 4,880,505     4,880,505                    
Term       5 years                    
Subsequent Event | Ordinary Share Warrants | Purchasers | Purchase agreement                            
Liquidity                            
Number of ordinary shares that can be purchased by warrant holders | shares       300,000                    
Nominal value | $ / shares $ 0.01     $ 0.01                    
Share and warrant price | $ / shares       2.4525                    
Exercise price | $ / shares       $ 2.39                    
Subsequent Event | Pre-Funded Warrants | Purchasers | Purchase agreement                            
Liquidity                            
Number of ordinary shares that can be purchased by warrant holders | shares       600,000                    
Share and warrant price | $ / shares       $ 2.4425                    
Exercise price | $ / shares       $ 0.01