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Share-Based Payments (Tables)
12 Months Ended
Dec. 31, 2020
Share-Based Payments  
Schedule of allocation of share-based compensation expense

Year ended December 31, 

(in thousands)

    

2018

    

2019

    

2020

Research and development

$

1,406

$

2,138

$

1,280

Selling, general and administrative 

 

3,748

 

7,610

 

3,939

Total

$

5,154

$

9,748

$

5,219

Stock Option Plan 2015  
Share-Based Payments  
Summary of information regarding stock option awards

2018

2019

2020

Weighted

Weighted

Weighted

average

average

average

exercise

exercise

exercise

Aggregate

price in

price in

price in

intrinsic

Stock Option Plan 2015

Options

    

$ per share

Options

    

$ per share

    

Options

    

$ per share

    

value

Outstanding as of January 1,

304,489

83.54

284,291

 

83.41

229,060

83.27

 

  

Granted

 

 

Exercised

 

 

Forfeited

(20,198)

84.07

(55,231)

 

84.01

(26,686)

 

87.46

 

Outstanding as of December 31, 

284,291

 

83.41

229,060

 

83.27

 

202,374

82.71

$

Vested and exercisable as of December 31, 

184,459

 

80.97

198,491

 

81.98

 

198,574

 

82.51

$

2017 Share Incentive Plan  
Share-Based Payments  
Summary of information regarding stock option awards

2018

2019

2020

    

Weighted

    

Weighted

    

Weighted

average

average

average

exercise

exercise

exercise

Aggregate

price in $

price in $

price in $

intrinsic

2017 Plan

Options

    

per share

Options

    

per share

    

Options

    

per share

    

value

Outstanding as of January 1,

29,410

69.17

239,842

54.14

 

442,266

35.48

 

 

  

Granted 

219,922

52.71

246,330

19.51

 

129,050

13.50

 

 

  

Exercised 

 

 

 

  

Forfeited 

(9,490)

67.52

(43,906)

47.87

 

(128,472)

29.39

 

Outstanding as of December 31, 

239,842

54.14

442,266

35.48

 

442,844

30.89

$

Vested and exercisable as of December 31, 

11,928

68.77

112,028

55.33

 

228,731

39.02

$

Summary of assumptions used for valuation of options

Input parameters

2018

    

2019

    

2020

Range of expected volatility

59.8% - 61.4%

 

61.4% - 63.1%

 

63.8% - 64.0%

Expected term of options (in years)

6.1

 

6.0

 

6.1

Range of risk-free interest rate

2.6% - 3.0%

 

1.9% - 2.6%

 

0.8% - 1.5%

Dividend yield

 

 

Summary of information regarding restricted stock awards

2019

2020

Weighted

Weighted

average fair

average fair

2017 Plan

RSUs

value in $ per share

RSUs

value in $ per share

Outstanding as of January 1,

122,210

33.10

90,169

27.37

Granted

47,900

19.00

155,730

13.50

Vested and issued

(65,758)

31.80

(51,671)

30.95

Forfeited

(14,183)

27.87

(42,959)

17.23

Outstanding as of December 31,

90,169

27.37

151,269

14.56

2019 Inducement Plan  
Share-Based Payments  
Summary of information regarding stock option awards

2019

2020

    

Weighted

Weighted

average

average

exercise

exercise

Aggregate

price in $

price in $

intrinsic

2019 Inducement Plan

    

Options

    

per share

    

Options

    

per share

    

value

Outstanding as of January 1

 

 

60,565

21.45

 

  

Granted 

 

70,315

22.20

 

18,200

13.50

 

  

Exercised 

 

 

 

 

  

Forfeited 

 

(9,750)

26.92

 

(52,950)

19.59

 

  

Outstanding as of December 31

 

60,565

21.45

 

25,815

19.04

Vested and exercisable as of December 31

 

 

4,396

26.96

Summary of assumptions used for valuation of options

Input parameters

    

2019

2020

Range of expected volatility

 

59.8% - 61.4%

63.7% - 64.0%

Expected term of options (in years)

 

6.1

6.1

Range of risk-free interest rate

 

2.55% - 3.03%

0.96% - 1.37%

Dividend yield

 

Inducement Awards Outside of the 2019 Inducement Plan  
Share-Based Payments  
Summary of assumptions used for valuation of options

Input parameters

    

Expected volatility

 

59.8

%

Expected term of options (in years)

 

6.1

Range of risk-free interest rate

 

2.9

%

Dividend yield

 

2020 Share Incentive Plan  
Share-Based Payments  
Summary of information regarding stock option awards

    

2020

    

Weighted

average

exercise

Aggregate

price in $

intrinsic

2020 Plan

    

Options

    

per share

    

value

Outstanding as of January 1,

 

 

  

Granted 

 

317,805

10.24

 

  

Exercised 

 

 

  

Forfeited 

 

(21,000)

7.88

 

  

Outstanding as of December 31, 

 

296,805

10.18

Vested and exercisable as of December 31, 

 

Summary of assumptions used for valuation of options

Input parameters

    

2020

Expected volatility

 

73.0% - 74.4%

Expected term of options (in years)

 

5.5 - 6.1

Risk-free interest rate

 

0.34% - 0.51%

Dividend yield