Stockholders' Equity	12 Months Ended
Dec. 31, 2020
Stockholders' Equity
Stockholders' Equity	9. Stockholders’ Equity In December 2020, the Company completed a registered public offering in which it sold 6,000,000 ordinary shares at a public offering price of $2.50. The proceeds to the Company from the offering were $15.0 million gross and $13.3 million net, after deducting the placement agent’s fees and other offering expenses. In May 2020, the Company sold to certain institutional investors, including Fidelity Management & Research Company, LLC, in a registered direct offering an aggregate of 4,144,537 ordinary shares and accompanying warrants to purchase up to an aggregate of 4,144,537 ordinary shares at a combined price of $9.1686 per security. The proceeds to the Company from the offering were $38.0 million gross and $35.2 million net, after deducting the placement agent’s fees and other offering expenses. As of December 31, 2020, there were 4,059,532 warrants outstanding, where each warrant has an exercise price of $7.92 per share and is immediately exercisable and will expire on the two-year anniversary of the issuance date. In December 2019, the Company sold to certain institutional investors in a registered direct offering an aggregate of 1,379,310 ordinary shares, and accompanying warrants to purchase up to an aggregate of 1,379,310 ordinary shares. Each share was issued and sold together with an accompanying warrant at a combined price of $14.50 per security. The proceeds to the Company from the offering were $20.0 million gross and $18.3 million net, after deducting the placement agent’s fees and other offering expenses. As of December 31, 2020, there were 1,379,310 warrants outstanding, where each warrant has an exercise price of $19.00 per share and is initially exercisable six months following the date of issuance, or the Initial Exercise Date, and will expire on the three-year anniversary of the Initial Exercise Date. In June 2019, the Company entered into an Open Market Sale Agreement^SM (the “Jefferies ATM Agreement”) with Jefferies, pursuant to which, from time to time, the Company may offer and sell ordinary shares, for aggregate gross sale proceeds of up to $50.0 million through Jefferies by any method permitted that is deemed an “at the market offering” as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended. As of December 31, 2020, the Company has issued and sold an aggregate of 1,992,390 ordinary shares pursuant to the Jefferies ATM Agreement and received gross proceeds of $21.9 million and net proceeds of $20.4 million, after deducting commissions to Jefferies and other offering expenses. From January 1, 2021 and through the date of this filing, the Company sold and issued 3,933,350 ordinary shares pursuant to the Jefferies ATM Agreement for net proceeds of approximately $11.5 million. As of the date of this filing, the Company may issue and sell ordinary shares for gross proceeds of up to $16.3 million. In July 2018, the Company completed an underwritten public offering and issued 1,818,181 ordinary shares at a public offering price of $27.50 per share, resulting in gross proceeds of $50.0 million and net proceeds to the Company of $46.3 million, after deducting underwriting discounts and commissions and offering expenses. In March 2018, the Company entered into a Controlled Equity Offering^SM Sales Agreement, or the ATM Agreement, with Cantor Fitzgerald & Co., or Cantor, pursuant to which, from time to time, the Company was able to offer and sell its ordinary shares having aggregate gross proceeds of up to $50.0 million through Cantor. The Company terminated the Cantor ATM Agreement effective as of June 24, 2019. The Company did not incur any penalties as a result of the termination of the Cantor ATM Agreement. As of the effective date of the termination of the Cantor ATM Agreement, the Company had issued and sold an aggregate of 1,031,619 of our ordinary shares pursuant to the Cantor ATM Agreement for aggregate gross proceeds of $37.8 million and net proceeds of $36.3 million, after deducting commissions and offering expenses. The $12.2 million of ordinary shares that had been available for sale pursuant to the Cantor ATM Agreement remained unsold at the time of its termination.

Stockholders' Equity

12 Months Ended

Dec. 31, 2020

9. Stockholders’ Equity

In December 2020, the Company completed a registered public offering in which it sold 6,000,000 ordinary shares at a public offering price of $2.50. The proceeds to the Company from the offering were $15.0 million gross and $13.3 million net, after deducting the placement agent’s fees and other offering expenses.

In May 2020, the Company sold to certain institutional investors, including Fidelity Management & Research Company, LLC, in a registered direct offering an aggregate of 4,144,537 ordinary shares and accompanying warrants to purchase up to an aggregate of 4,144,537 ordinary shares at a combined price of $9.1686 per security. The proceeds to the

Company from the offering were $38.0 million gross and $35.2 million net, after deducting the placement agent’s fees and other offering expenses. As of December 31, 2020, there were 4,059,532 warrants outstanding, where each warrant has an exercise price of $7.92 per share and is immediately exercisable and will expire on the two-year anniversary of the issuance date.

In December 2019, the Company sold to certain institutional investors in a registered direct offering an aggregate of 1,379,310 ordinary shares, and accompanying warrants to purchase up to an aggregate of 1,379,310 ordinary shares. Each share was issued and sold together with an accompanying warrant at a combined price of $14.50 per security. The proceeds to the Company from the offering were $20.0 million gross and $18.3 million net, after deducting the placement agent’s fees and other offering expenses. As of December 31, 2020, there were 1,379,310 warrants outstanding, where each warrant has an exercise price of $19.00 per share and is initially exercisable six months following the date of issuance, or the Initial Exercise Date, and will expire on the three-year anniversary of the Initial Exercise Date.

In June 2019, the Company entered into an Open Market Sale Agreement^SM (the “Jefferies ATM Agreement”) with Jefferies, pursuant to which, from time to time, the Company may offer and sell ordinary shares, for aggregate gross sale proceeds of up to $50.0 million through Jefferies by any method permitted that is deemed an “at the market offering” as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended. As of December 31, 2020, the Company has issued and sold an aggregate of 1,992,390 ordinary shares pursuant to the Jefferies ATM Agreement and received gross proceeds of $21.9 million and net proceeds of $20.4 million, after deducting commissions to Jefferies and other offering expenses. From January 1, 2021 and through the date of this filing, the Company sold and issued 3,933,350 ordinary shares pursuant to the Jefferies ATM Agreement for net proceeds of approximately $11.5 million. As of the date of this filing, the Company may issue and sell ordinary shares for gross proceeds of up to $16.3 million.

In July 2018, the Company completed an underwritten public offering and issued 1,818,181 ordinary shares at a public offering price of $27.50 per share, resulting in gross proceeds of $50.0 million and net proceeds to the Company of $46.3 million, after deducting underwriting discounts and commissions and offering expenses.

In March 2018, the Company entered into a Controlled Equity Offering^SM Sales Agreement, or the ATM Agreement, with Cantor Fitzgerald & Co., or Cantor, pursuant to which, from time to time, the Company was able to offer and sell its ordinary shares having aggregate gross proceeds of up to $50.0 million through Cantor. The Company terminated the Cantor ATM Agreement effective as of June 24, 2019. The Company did not incur any penalties as a result of the termination of the Cantor ATM Agreement. As of the effective date of the termination of the Cantor ATM Agreement, the Company had issued and sold an aggregate of 1,031,619 of our ordinary shares pursuant to the Cantor ATM Agreement for aggregate gross proceeds of $37.8 million and net proceeds of $36.3 million, after deducting commissions and offering expenses. The $12.2 million of ordinary shares that had been available for sale pursuant to the Cantor ATM Agreement remained unsold at the time of its termination.