Consolidated Statements of Operations - USD ($)	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Total Revenue	$ 1,703,000	$ 7,551,000
Operating expenses:
Research and development	(7,538,000)	(10,279,000)
General and administrative	(13,409,000)	(10,136,000)
Total operating expenses	(20,947,000)	(20,415,000)
Loss from operations	(19,244,000)	(12,864,000)
Other income (expense):
Other income (expense), net	70,000	23,000
Interest income	10,000	9,000
Interest expense	(899,000)	(4,000)
Loss before income taxes	(20,063,000)	(12,836,000)
Income tax expense	(154,000)	(506,000)
Net loss	$ (20,217,000)	$ (13,342,000)
Loss per share
Basic and diluted (in dollars per share)	$ (0.29)	$ (0.36)
Weighted average number of shares:
Basic and diluted (in shares)	68,701,599	36,911,604
Collaboration revenue
Revenues:
Total Revenue	$ 1,000,000	$ 6,500,000
Research premium and grant revenue
Revenues:
Total Revenue	$ 703,000	$ 1,051,000