Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Total revenue	$ 847,000	$ 1,051,000	$ 8,398,000	$ 2,729,000
Operating expenses:
Research and development	(9,717,000)	(11,043,000)	(19,996,000)	(23,703,000)
General and administrative	(8,837,000)	(5,570,000)	(18,973,000)	(9,788,000)
Total operating expenses	(18,554,000)	(16,613,000)	(38,969,000)	(33,491,000)
Loss from operations	(17,707,000)	(15,562,000)	(30,571,000)	(30,762,000)
Other income (expense):
Other income (expense), net	(141,000)	(116,000)	(118,000)	90,000
Interest income	19,000	112,000	28,000	233,000
Interest expense	(7,000)	(3,000)	(11,000)	(4,000)
Loss before income taxes	(17,836,000)	(15,569,000)	(30,672,000)	(30,443,000)
Income tax benefit (expense)	48,000	967,000	(458,000)	618,000
Net loss	(17,788,000)	(14,602,000)	(31,130,000)	(29,825,000)
Other comprehensive income (loss), net of tax
Unrealized losses on available-for-sale financial assets		(10,000)		(26,000)
Other comprehensive income (loss), net of tax		(10,000)		(26,000)
Comprehensive loss	$ (17,788,000)	$ (14,612,000)	$ (31,130,000)	$ (29,851,000)
Loss per share
Basic and Diluted (in dollars per share)	$ (0.44)	$ (0.54)	$ (0.80)	$ (1.10)
Weighted average number of shares:
Basic and Diluted (in shares)	40,515,920	27,186,560	38,723,718	27,197,070
Collaboration revenues
Revenues:
Total revenue			$ 6,500,000
Research premium and grant revenue
Revenues:
Total revenue	$ 847,000	$ 1,051,000	$ 1,898,000	$ 2,729,000