Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenues:
Total Revenue	$ 7,551,000	$ 1,678,000
Operating expenses:
Research and development	(10,279,000)	(12,660,000)
General and administrative	(10,136,000)	(4,218,000)
Total operating expenses	(20,415,000)	(16,878,000)
Loss from operations	(12,864,000)	(15,200,000)
Other income (expense):
Other income, net	23,000	206,000
Interest income	9,000	121,000
Interest expense	(4,000)	(1,000)
Loss before income taxes	(12,836,000)	(14,874,000)
Income tax expense	(506,000)	(349,000)
Net loss	(13,342,000)	(15,223,000)
Other comprehensive income (loss), net of tax
Unrealized losses on available-for-sale securities		(16,000)
Other comprehensive income (loss), net of tax		(16,000)
Comprehensive loss	$ (13,342,000)	$ (15,239,000)
Loss per share
Basic and Diluted (in dollars per share)	$ (0.36)	$ (0.56)
Weighted average number of shares:
Basic and Diluted (in shares)	36,911,604	27,204,230
Collaboration revenue
Revenues:
Total Revenue	$ 6,500,000
Research premium and grant revenue
Revenues:
Total Revenue	$ 1,051,000	$ 1,678,000