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Commitments and Contingencies - Lease Arrangements (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2007
Lease Arrangements          
Rent expense     $ 304,000 $ 272,000  
Obligations payable under the lease agreement:          
No later than 1 year $ 1,252,000 $ 1,484,000 1,252,000    
Later than 1 year and no later than 5 years 2,572,000 2,536,000 2,572,000    
Later than 5 years 515,000 507,000 515,000    
Total 4,339,000 4,527,000 $ 4,339,000    
Lease agreement for use of business and research premises at Vienna          
Lease Arrangements          
Term of the lease agreement, under which it can only be terminated under certain conditions         10 years
Monthly costs for facility management and security services 9,000 9,000      
Lease agreement for use of business and research premises at Vienna | Premises and laboratory furniture          
Lease Arrangements          
Monthly rent 84,000 85,000      
Lease agreement for use of office premises at King of Prussia, Suite 600          
Lease Arrangements          
Monthly rent $ 40,000 $ 40,000