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Selected Quarterly Financial Information (Unaudited) (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Selected Quarterly Financial Information (Unaudited)                      
Revenues $ 797 $ 461 $ 847 $ 7,551 $ 1,122 $ 1,468 $ 1,051 $ 1,678 $ 9,656 $ 5,319 $ 6,482
Operating expenses (31,676) (53,386) (18,554) (20,415) (23,403) (22,193) (16,613) (16,878) (124,031) (79,087) (61,529)
Loss from operations (30,879) (52,925) (17,707) (12,864) (22,281) (20,725) (15,562) (15,200) (114,375) (73,768) (55,047)
Other income (expense) (204) (51) (129) 28 120 328 (7) 326      
Income tax (expense) benefit 259 151 48 (506) (101) (1,872) 967 (349) (49) (1,355) 672
Net loss $ (30,824) $ (52,825) $ (17,788) $ (13,342) $ (22,262) $ (22,269) $ (14,602) $ (15,223) $ (114,780) $ (74,356) $ (54,890)
Basic and diluted loss per share $ (0.46) $ (0.90) $ (0.44) $ (0.36) $ (0.61) $ (0.79) $ (0.54)   $ (2.26) $ (2.49) $ (2.56)
Restatement Adjustment | Redomiciliation Transaction                      
Selected Quarterly Financial Information (Unaudited)                      
Basic and diluted loss per share               $ (0.56)