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Organization and Business Activities (Details) - USD ($) $ / shares in Units, $ in Thousands			1 Months Ended	3 Months Ended	12 Months Ended
	Jul. 31, 2018	Sep. 22, 2017	Feb. 28, 2019	Mar. 31, 2019	Mar. 05, 2019	Dec. 31, 2018	Mar. 31, 2018
Liquidity
Cash, cash equivalents and short-term investments						$ 102,200
At-the-market offering
Liquidity
Proceeds from issuance of stock						24,219
At-the-market offering \| Ordinary Shares
Liquidity
Proceeds from issuance of stock					$ 30,300	$ 24,200
Number of shares issued					7,742,379	4,778,031
Net proceeds from sale of stock					$ 28,900	$ 23,000
Public offering \| Ordinary Shares
Liquidity
Proceeds from issuance of stock	$ 50,000	$ 80,000
Number of shares issued	18,181,818	9,411,765
Shares issued, price per share	$ 2.75	$ 8.50
Net proceeds from sale of stock	$ 46,300	$ 73,300
License Agreement \| Clinical trial application submission \| Sinovant Sciences, LTD
Liquidity
Milestone payment received			$ 1,500
Loan Agreement \| Term loan
Liquidity
Maximum borrowing capacity						75,000
Loan Agreement \| Term loan \| Initial Advance
Liquidity
Principal amount of advances outstanding						25,000
Loan Agreement \| Term loan \| Additional Funding Subject to Certain Conditions [Member]
Liquidity
Remaining amount under the loan agreement						50,000
Loan Agreement \| Term loan \| Tranche 2 Advance
Liquidity
Maximum borrowing capacity						10,000
Loan Agreement \| Term loan \| Tranche 3 Advance
Liquidity
Maximum borrowing capacity						$ 5,000
ATM Agreement
Liquidity
Proceeds from issuance of stock				$ 5,900
ATM Agreement \| Cantor Fitzgerald and Co. \| Ordinary Shares
Liquidity
Maximum aggregate gross proceeds under the sales agreement							$ 50,000