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Selected Quarterly Financial Information (Unaudited) (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Selected Quarterly Financial Information (Unaudited)                      
Revenues $ 1,122 $ 1,468 $ 1,051 $ 1,678 $ 2,307 $ 971 $ 1,785 $ 1,419 $ 5,319 $ 6,482 $ 3,767
Operating expenses (23,403) (22,193) (16,613) (16,878) (17,047) (15,050) (13,311) (16,121) (79,087) (61,529) (31,525)
Loss from operations (22,281) (20,725) (15,562) (15,200) (14,740) (14,079) (11,526) (14,702) (73,768) (55,047) (27,758)
Other income (expense) 120 328 (7) 326 (1,118) 107 (590) 1,086 492 (783) 2,427
Income tax (expense) benefit (101) (1,872) 967 (349) 671 (28) 12 17 (1,355) 672 445
Net loss $ (22,262) $ (22,269) $ (14,602) $ (15,223) $ (15,187) $ (14,000) $ (12,104) $ (13,599) $ (74,356) $ (54,890) $ (46,964)
Basic and diluted loss per share $ (0.61) $ (0.79) $ (0.54)           $ (2.49) $ (2.56) $ (4.80)
Restatement Adjustment | Redomiciliation Transaction                      
Selected Quarterly Financial Information (Unaudited)                      
Basic and diluted loss per share       $ (0.56) $ (0.68) $ (0.66) $ (0.57) $ (0.64)