XML 61 R46.htm IDEA: XBRL DOCUMENT v3.22.1
Collaboration Agreements - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Dec. 21, 2017
May 31, 2018
Aug. 31, 2017
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Jan. 14, 2021
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Research and development       $ 13,324,000 $ 11,015,000 $ 15,119,000  
Collaborative Arrangements [Member] | Reneo [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
License fee received $ 3,000,000.0            
Collaboration revenue recognized       2,000,000.0   1,700,000  
Collaborative Arrangements [Member] | Reneo [Member] | Maximum [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Potential development and regulatory milestone payments 94,500,000            
Collaborative Arrangements [Member] | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
License fee received 8,000,000.0            
Potential regulatory milestone payments based on regulatory approval 20,000,000.0            
Potential sales-based milestones based on tiered sales of licensed products 50,000,000.0            
Collaborative Arrangements [Member] | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. [Member] | Phase 2 MRCT [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Potential development and regulatory milestone payments             $ 3,000,000.0
Maximum contribution amount to clinical trial             $ 3,000,000.0
Unrecognized amount of transaction price allocated to performance obligation       1,000,000.0      
Collaborative Arrangements [Member] | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. [Member] | Phase 2 MRCT [Member] | License and Technology Transfer Services of Chemistry and Manufacturing Know-How [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Adjustments to transaction price for performance obligations       1,000,000.0      
Collaborative Arrangements [Member] | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. [Member] | Joint Development Committee [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Unrecognized amount of transaction price allocated to performance obligation       100,000      
Collaborative Arrangements [Member] | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. [Member] | Maximum [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Potential development and regulatory milestone payments $ 22,000,000.0            
Collaborative Arrangements [Member] | Newsoara Biopharma Co., Ltd. [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
License fee received   $ 2,000,000.0          
Potential development and regulatory milestone payments   $ 58,500,000          
Collaboration revenue recognized           1,000,000.0  
Collaborative Arrangements [Member] | Newsoara Biopharma Co., Ltd. [Member] | License And Technology Transfer Services [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Revenue recognized from change in estimated transaction prices       1,000,000.0   $ 1,000,000.0  
Collaborative Arrangements [Member] | Anteris Bio, Inc. [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
License fee received       2,000,000.0      
Potential development and regulatory milestone payments       151,000,000.0      
Collaborative Arrangements [Member] | Anteris Bio, Inc. [Member] | License and Technology Transfer Services of Chemistry and Manufacturing Know-How [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
License fee received       2,000,000.0      
Collaboration revenue recognized       0      
Equity interest received       4,200,000      
Collaborative Arrangements [Member] | JDRF [Member]              
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]              
Maximum research funding receivable achievement based on research and development milestones     $ 3,400,000        
Maximum funding percentage of research and development milestones     50.00%        
Funding received       3,400,000      
Research and development       $ 3,400,000