10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

________________________________________________________________________________________________________

FORM 10-Q

________________________________________________________________________________________________________

(Mark One)

☒    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2022

☐    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ______________ to ______________.

Commission File Number 001-37998

________________________________________________________________________________________________________

JOUNCE THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

________________________________________________________________________________________________________

Delaware		45-4870634
(State or other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification No.)
780 Memorial Drive
Cambridge,	Massachusetts	02139
(Address of principal executive offices)		(Zip Code)

Registrant’s telephone number, including area code: (857) 259-3840

    Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $0.001 par value per share	JNCE	The Nasdaq Stock Market LLC

    Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒  No ☐ 

    Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).  Yes ☒  No ☐

    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☐
Non-accelerated filer	☒	Smaller reporting company	☒
		Emerging growth company	☒

    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☒  

    Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐  No ☒

    As of November 7, 2022, there were 51,694,237 shares of common stock, $0.001 par value per share, outstanding.

Table of Contents

		Page
PART I. FINANCIAL INFORMATION
Item 1.	Financial Statements (unaudited)	3
	Condensed Consolidated Balance Sheets as of September 30, 2022 and December 31, 2021	3
	Condensed Consolidated Statements of Operations and Comprehensive Loss for the Three and Nine Months Ended September 30, 2022 and 2021	4
	Condensed Consolidated Statements of Stockholders’ Equity for the Three and Nine Months Ended September 30, 2022 and 2021	5
	Condensed Consolidated Statements of Cash Flows for the Nine Months Ended September 30, 2022 and 2021	6
	Notes to Condensed Consolidated Financial Statements	7
Item 2.	Management's Discussion and Analysis of Financial Condition and Results of Operations	16
Item 3.	Quantitative and Qualitative Disclosures about Market Risk	25
Item 4.	Controls and Procedures	25
PART II. OTHER INFORMATION
Item 1.	Legal Proceedings	27
Item 1A.	Risk Factors	27
Item 6.	Exhibits	28
SIGNATURES

References to Jounce

Throughout this Quarterly Report on Form 10-Q, the “Company,” “Jounce,” “Jounce Therapeutics,” “we,” “us,” and “our,” except where the context requires otherwise, refers to Jounce Therapeutics, Inc. and its consolidated subsidiary, and “board of directors” refers to the board of directors of Jounce Therapeutics, Inc.

Cautionary Note Regarding Forward-Looking Statements and Industry Data

This Quarterly Report on Form 10-Q contains forward-looking statements that involve substantial risks and uncertainties. All statements other than statements of historical facts contained in this Quarterly Report on Form 10-Q, including statements regarding our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans, objectives of management and expected market growth, are forward-looking statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.

The words “aim,” “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “goal,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “target,” “will” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements include, among other things, statements about:

•the timing, progress, and results of preclinical studies and clinical trials for our current and future product candidates, including statements regarding the timing of initiation and completion of studies or trials and related preparatory work, the period during which the results of the trials will become available, and our research and development programs;

•our plans and expectations in light of the COVID-19 pandemic and its impacts on our operations and global healthcare systems;

•the timing, scope, or likelihood of regulatory filings and approvals, including, as applicable, timing of our investigational new drug applications for, biologics license application filing for, and final Food and Drug Administration approval of our current and future product candidates;

•our ability to use our Translational Science Platform to identify targets for future product candidates and to match immunotherapies to select patient subsets;

•our ability to identify, develop and advance future product candidates into, and successfully complete, clinical studies;

•our ability to develop combination therapies, whether on our own or in collaboration with third parties, for our current and future product candidates;

•our expectations regarding the size of the patient populations for our product candidates, if approved for commercial use, and any product candidates we may develop;

•our commercialization and marketing capabilities and strategy;

•the pricing and reimbursement of our current and future product candidates, if approved;

•the implementation of our business model and our strategic plans for our business, our current and future product candidates, and our technology;

•our ability to develop and commercialize a companion diagnostic or complementary diagnostic for our current and future product candidates;

•the rate and degree of market acceptance and clinical utility of our current and future product candidates;

•the potential benefits of our exclusive license of GS-1811, formerly JTX-1811, to Gilead Sciences, Inc.;

•our ability to establish or maintain future collaborations or strategic relationships or obtain additional funding;

•our ability to retain the continued service of our key professionals and to identify, hire and retain additional qualified professionals;

•our intellectual property position, including the scope of protection we are able to establish and maintain for intellectual property rights covering our current and future product candidates, and our ability not to infringe, misappropriate or otherwise violate any third-party intellectual property rights;

•our competitive position, and developments and projections relating to our competitors and our industry;

•our estimates regarding expenses, future revenue, capital requirements and needs for additional financing; and

1

•the impact of laws and regulations.

There are a number of important risks and uncertainties that could cause our actual results to differ materially from those indicated by forward-looking statements. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. You should also read carefully the factors described in the sections “Summary of Risks Factors” and “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2021 to better understand the risks and uncertainties inherent in our business and underlying any forward-looking statements. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures or investments that we may make.

You should read this Quarterly Report on Form 10-Q and the documents that we have filed as exhibits to this Quarterly Report on Form 10-Q completely and with the understanding that our actual future results may be materially different from what we expect. The forward-looking statements contained in this Quarterly Report on Form 10-Q are made as of the date of this Quarterly Report on Form 10-Q, and we do not assume any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law.

This Quarterly Report on Form 10-Q may include industry and market data, which we may obtain from our own internal estimates and research, as well as from industry and general publications and research, surveys, and studies conducted by third parties. Industry publications, studies, and surveys generally state that they have been obtained from sources believed to be reliable, although they do not guarantee the accuracy or completeness of such information. While we believe that such studies and publications are reliable, we have not independently verified market and industry data from third‑party sources.

Website and Social Media Disclosure

From time to time, we may use our website (www.jouncetx.com), investor and media relations website (http://ir.jouncetx.com), Facebook page (https://www.facebook.com/jouncetx), LinkedIn page (https://www.linkedin.com/company/3494537/) and Twitter feed (https://twitter.com/JounceTx) as channels for the distribution of information. The information we post through these channels may be deemed material. Accordingly, investors should monitor these channels, in addition to following our press releases, Securities and Exchange Commission filings and public conference calls and webcasts. The contents of our website and social media channels are not, however, a part of this report.

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PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

Jounce Therapeutics, Inc.

Condensed Consolidated Balance Sheets (unaudited)

(amounts in thousands, except par value amounts)

d

	September 30,		December 31,
	2022		2021
Assets:
Current assets:
Cash and cash equivalents	$	77,111	$	95,529
Short-term investments	51,498		83,037
Prepaid expenses and other current assets	11,321		12,261
Total current assets	139,930		190,827
Property and equipment, net	3,926		4,882
Long-term investments	1,723		41,657
Operating lease right-of-use asset	9,440		11,877
Other non-current assets	3,062		3,453
Total assets	$	158,081	$	252,696
Liabilities and stockholders’ equity:
Current liabilities:
Accounts payable	$	1,115	$	1,674
Accrued expenses	16,604		13,467
Operating lease liability, current	4,024		3,695
Other current liabilities	54		62
Total current liabilities	21,797		18,898
Operating lease liability, net of current portion	6,926		9,993
Total liabilities	28,723		28,891
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value: 5,000 shares authorized at September 30, 2022 and December 31, 2021; no shares issued or outstanding at September 30, 2022 or December 31, 2021	—		—
Common stock, $0.001 par value: 160,000 shares authorized at September 30, 2022 and December 31, 2021; 51,694 and 51,265 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively	51		51
Additional paid-in capital	474,089		465,865
Accumulated other comprehensive loss	(1,031)		(238)
Accumulated deficit	(343,751)		(241,873)
Total stockholders’ equity	129,358		223,805
Total liabilities and stockholders’ equity	$	158,081	$	252,696

The accompanying notes are an integral part of these condensed consolidated financial statements.

3

Jounce Therapeutics, Inc.

Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited)

(amounts in thousands, except per share amounts)

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Revenue:
License and collaboration revenue — related party	$	—	$	—	$	—	$	26,907
Operating expenses:
Research and development	23,752		23,288		80,070		65,895
General and administrative	7,653		6,854		22,511		21,786
Total operating expenses	31,405		30,142		102,581		87,681
Operating loss	(31,405)		(30,142)		(102,581)		(60,774)
Other income, net	412		55		721		144
Loss before provision for income taxes	(30,993)		(30,087)		(101,860)		(60,630)
Provision for income taxes	5		6		18		9
Net loss	$	(30,998)	$	(30,093)	$	(101,878)	$	(60,639)
Net loss per share, basic and diluted	$	(0.60)	$	(0.59)	$	(1.97)	$	(1.23)
Weighted-average common shares outstanding, basic and diluted	51,694		51,232		51,670		49,488
Comprehensive loss:
Net loss	$	(30,998)	$	(30,093)	$	(101,878)	$	(60,639)
Other comprehensive income (loss):
Unrealized gain (loss) on available-for-sale securities	66		5		(793)		(2)
Comprehensive loss	$	(30,932)	$	(30,088)	$	(102,671)	$	(60,641)

The accompanying notes are an integral part of these condensed consolidated financial statements.

4

Jounce Therapeutics, Inc.

Condensed Consolidated Statements of Stockholders’ Equity (unaudited)

(amounts in thousands)

	Common Stock			Additional Paid-In Capital		Accumulated Other Comprehensive Loss		Accumulated Deficit		Total Stockholders’ Equity
	Shares	Amount
Balance at December 31, 2021	51,265	$	51	$	465,865	$	(238)	$	(241,873)	$	223,805
Exercises of common stock options	64	—		359		—		—		359
Vesting of restricted stock units	345	—		—		—		—		—
Stock-based compensation expense	—	—		2,829		—		—		2,829
Other comprehensive loss	—	—		—		(663)		—		(663)
Net loss	—	—		—		—		(37,367)		(37,367)
Balance at March 31, 2022	51,674	51		469,053		(901)		(279,240)		188,963
Exercises of common stock options	7	—		33		—		—		33
Stock-based compensation expense	—	—		2,443		—		—		2,443
Other comprehensive loss	—	—		—		(196)		—		(196)
Net loss	—	—		—		—		(33,513)		(33,513)
Balance at June 30, 2022	51,681	$	51	$	471,529	$	(1,097)	$	(312,753)	$	157,730
Vesting of restricted stock units	13	—		—		—		—		—
Stock-based compensation expense	—	—		2,560		—		—		2,560
Other comprehensive income	—	—		—		66		—		66
Net loss	—	—		—		—		(30,998)		(30,998)
Balance at September 30, 2022	51,694	$	51	$	474,089	$	(1,031)	$	(343,751)	$	129,358
	Common Stock			Additional Paid-In Capital		Accumulated Other Comprehensive Loss		Accumulated Deficit		Total Stockholders’ Equity
	Shares	Amount
Balance at December 31, 2020	41,729	$	42	$	362,270	$	(17)	$	(151,001)	$	211,294
Issuance of common stock from at the market offering, net of issuance cost	3,156	3		30,218		—		—		30,221
Issuance of common stock from follow-on public offering, net of issuance costs	5,750	6		60,632		—		—		60,638
Exercise of common stock options	342	—		1,019		—		—		1,019
Vesting of restricted stock units	223	—		—		—		—		—
Stock-based compensation expense	—	—		2,825		—		—		2,825
Other comprehensive loss	—	—		—		(8)		—		(8)
Net loss	—	—		—		—		(26,535)		(26,535)
Balance at March 31, 2021	51,200	51		456,964		(25)		(177,536)		279,454
Exercises of common stock options	21	—		83		—		—		83
Stock-based compensation expense	—	—		2,935		—		—		2,935
Other comprehensive income	—	—		—		1		—		1
Net loss	—	—		—		—		(4,011)		(4,011)
Balance at June 30, 2021	51,221	$	51	$	459,982	$	(24)	$	(181,547)	$	278,462
Exercises of common stock options	15	—		67		—		—		67
Vesting of restricted stock awards and restricted stock units	4	—		—		—		—		—
Stock-based compensation expense	—	—		2,926		—		—		2,926
Other comprehensive income	—	—		—		5		—		5
Net loss	—	—		—		—		(30,093)		(30,093)
Balance at September 30, 2021	51,240	$	51	$	462,975	$	(19)	$	(211,640)	$	251,367

The accompanying notes are an integral part of these condensed consolidated financial statements.

5

Jounce Therapeutics, Inc.

Condensed Consolidated Statements of Cash Flows (unaudited)

(amounts in thousands)

	Nine Months Ended September 30,
	2022		2021
Operating activities:
Net loss	$	(101,878)	$	(60,639)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	7,832		8,686
Depreciation expense	1,645		2,184
Net amortization of premiums and discounts on investments	748		604
Gain on sale of property and equipment	(93)		—
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	975		(4,732)
Other non-current assets	391		360
Accounts payable	(559)		(290)
Accrued expenses and other current liabilities	3,129		640
Deferred revenue — related party	—		(1,931)
Other liabilities	(301)		(175)
Net cash used in operating activities	(88,111)		(55,293)
Investing activities:
Purchases of investments	(24,928)		(91,914)
Proceeds from maturities of investments	94,875		53,331
Purchases of property and equipment	(696)		(247)
Net cash provided by (used in) investing activities	69,251		(38,830)
Financing activities:
Proceeds from issuance of common stock, net of issuance costs	—		90,826
Proceeds from exercise of stock options	442		1,169
Net cash provided by financing activities	442		91,995
Net decrease in cash, cash equivalents and restricted cash	(18,418)		(2,128)
Cash, cash equivalents and restricted cash, beginning of period	96,799		148,763
Cash, cash equivalents and restricted cash, end of period	$	78,381	$	146,635
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accrued expenses	$	—	$	77
Supplemental cash flow information:
Cash paid for lease liabilities	$	3,498	$	3,760
Cash paid for income taxes	$	8	$	8

The accompanying notes are an integral part of these condensed consolidated financial statements.

6

Jounce Therapeutics, Inc.

Notes to Condensed Consolidated Financial Statements

(unaudited)

1. Nature of Business

Jounce Therapeutics, Inc. (the “Company”) is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. The Company is subject to a number of risks similar to those of other clinical-stage companies, including dependence on key individuals; the need to develop commercially viable products; competition from other companies, many of which are larger and better capitalized; and the need to obtain adequate additional financing to fund the development of its products.

As of September 30, 2022, the Company had cash, cash equivalents and investments of $130.3 million. The Company expects that its existing cash, cash equivalents and investments will enable it to fund its expected operating expenses and capital expenditure requirements for at least 12 months from November 10, 2022, the filing date of this Quarterly Report on Form 10-Q. The Company expects to finance its future cash needs through a combination of equity or debt financings, collaborations, licensing arrangements and strategic alliances.

2. Basis of Presentation and Summary of Significant Accounting Policies

Basis of Presentation and Consolidation

The accompanying condensed consolidated financial statements as of September 30, 2022 and December 31, 2021, and for the three and nine months ended September 30, 2022 and 2021, have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission (the “SEC”) and generally accepted accounting principles in the United States of America (“GAAP”) as found in the Accounting Standards Codification (“ASC”) of the Financial Accounting Standards Board (“FASB”) for condensed consolidated financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In the opinion of management, these condensed consolidated financial statements reflect all normal recurring adjustments which are necessary for a fair presentation of the Company’s financial position and results of its operations, as of and for the periods presented. These condensed consolidated financial statements should be read in conjunction with the consolidated financial statements and notes thereto contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC on March 2, 2022 (the “Annual Report on Form 10-K”).

The information presented in the condensed consolidated financial statements and related notes as of September 30, 2022, and for the three and nine months ended September 30, 2022 and 2021, is unaudited. The December 31, 2021 condensed consolidated balance sheet included herein was derived from the audited financial statements as of that date, but does not include all disclosures, including notes, required by GAAP for complete financial statements.

Interim results for the nine months ended September 30, 2022 are not necessarily indicative of the results that may be expected for the fiscal year ending December 31, 2022, or any future period.

The accompanying condensed consolidated financial statements include the accounts of Jounce Therapeutics, Inc. and its wholly-owned subsidiary, Jounce Mass Securities, Inc. All intercompany transactions and balances have been eliminated in consolidation.

Summary of Significant Accounting Policies

The significant accounting policies and estimates used in the preparation of the condensed consolidated financial statements are described in the Company’s audited financial statements as of and for the year ended December 31, 2021, and the notes thereto, which are included in the Annual Report on Form 10-K. There have been no material changes in the Company’s significant accounting policies during the nine months ended September 30, 2022.

Use of Estimates

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. On an ongoing basis, the Company’s management evaluates its estimates which include, but are not limited to, accrued expenses, stock-based compensation expense and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions it believes to be reasonable under the circumstances. Actual results could differ from those estimates.

7

Recent Accounting Pronouncements, Not Yet Adopted

In June 2016, the FASB issued Accounting Standards Update (“ASU”) 2016-13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments. This standard requires that credit losses be reported using an expected losses model rather than the incurred losses model that is currently used, and it establishes additional disclosure requirements related to credit risks. For available-for-sale debt securities with expected credit losses, this standard now requires allowances to be recorded instead of reducing the amortized cost of the investment. This ASU is effective for smaller reporting companies for fiscal years beginning after December 15, 2022, with early adoption permitted. Accordingly, the Company will now adopt this standard effective January 1, 2023. The adoption of ASU 2016-13 is not expected to have a material impact on the Company’s financial position or results of operations upon adoption.

3.     License and Collaboration Revenue

Gilead License Agreement

On August 31, 2020, the Company and Gilead Sciences, Inc. (“Gilead”) entered into an exclusive license agreement (the “Gilead License Agreement”) to license the Company’s GS-1811, formerly JTX-1811, program to Gilead, which became effective on October 16, 2020. Concurrently with the Gilead License Agreement, the Company and Gilead entered into a stock purchase agreement (the “Stock Purchase Agreement”) and a registration rights agreement (the “Registration Rights Agreement”, and together with the Gilead License Agreement and the Stock Purchase Agreement, the “Transaction Agreements”). Pursuant to the Gilead License Agreement, the Company granted to Gilead a worldwide and exclusive license to develop, manufacture and commercialize GS-1811 and certain derivatives thereof (the “Licensed Products”). Gilead paid the Company a one-time, non-refundable upfront payment of $85.0 million in October 2020. The Company continued to develop GS-1811 during the initial development term, which included conducting activities defined within the agreement to advance GS-1811 through the clearance of an investigational new drug application (“IND”), which occurred in June 2021, after which the program transitioned to Gilead.

Milestone and Royalties

The Company is entitled to receive payments from Gilead upon the achievement of specified clinical, regulatory and sales milestones, including potential clinical development and regulatory milestone payments up to an aggregate total of $510.0 million and potential sales milestone payments up to an aggregate total of $175.0 million.

The Company is also eligible to receive tiered royalty payments based on a percentage of annual worldwide net sales ranging from the high-single digits to mid-teens, based on future annual net sales of the Licensed Products, on a Licensed Product-by-Licensed Product and country-by-country basis.

In June 2021, the Company received clearance of the IND for GS-1811 from the U.S. Food and Drug Administration (“FDA”) and achieved a $25.0 million clinical development and regulatory milestone under the Gilead License Agreement.

Termination

Gilead may terminate the Gilead License Agreement for convenience, in its sole discretion, in its entirety or on a Licensed Product-by-Licensed Product or region-by-region basis, at any time with prior written notice to the Company. Unless terminated earlier in accordance with its terms, the Gilead License Agreement provides that it will expire (i) on a Licensed Product-by-Licensed Product (as defined in the Gilead License Agreement) and country-by-country basis on the date of the expiration of the royalty term with respect to such Licensed Product in such country and (ii) in its entirety upon the expiration of all applicable royalty terms with respect to the Licensed Products in all countries, following which the applicable licenses under the Gilead License Agreement will become fully paid-up, perpetual, irrevocable and royalty-free.

8

Accounting Analysis

Identification of the Contract(s)

The Company assessed the Gilead License Agreement and concluded that it represents a contract with a customer within the scope of ASC 606, Revenue from Contracts with Customers (“ASC 606”). In addition, the Company determined that the Gilead License Agreement and Stock Purchase Agreement should be evaluated as a combined contract in accordance with ASC 606 given that the agreements were executed contemporaneously, negotiated as a package and have the same commercial objective to provide funding to further the Company’s research and development activities.

Identification of Promises and Performance Obligations

The Company assessed the promises under the Gilead License Agreement and concluded that the (i) delivery of a worldwide and exclusive license to develop, manufacture and commercialize GS-1811 (the “GS-1811 License”) and (ii) provision of certain research transition activities, specifically outlined within the Gilead License Agreement, related to the advancement of GS-1811 through the clearance of an IND application and transition of the GS-1811 program to Gilead (the “Research and Transition Services”) are capable of being distinct and distinct within the context of the Gilead License Agreement. Based upon this evaluation, the Company concluded that its promise to deliver the GS-1811 License and promise to perform Research and Transition Services represent separate performance obligations in the Gilead License Agreement.

Determination of Transaction Price

The Company received a non-refundable upfront payment of $85.0 million upon the closing of the Gilead License Agreement. This upfront payment represents an element of fixed consideration under the Gilead License Agreement.

The Company also evaluated as possible variable consideration the milestones and royalties discussed above. With respect to clinical development and regulatory milestones, based upon the high degree of uncertainty and risk associated with these potential payments, the Company concluded that all such amounts should be fully constrained and are not included in the initial transaction price. As part of the evaluation of the constraint the Company considered certain factors, including that receipt of such milestones is outside the control of the Company and the probability of success criteria is estimated. Each of these variable consideration items was evaluated under the most-likely amount method. As for royalties and sales milestones, the Company determined that the royalties and milestones relate solely to the GS-1811 License, which is a license of intellectual property (“IP”). Accordingly, the Company did not include any potential royalty or sales milestone amounts in the initial transaction price, and the Company will not recognize revenue related to these royalties and sales milestones until the associated sales occur and relevant thresholds are met. The Company will re-evaluate the transaction price in each reporting period as uncertain events are resolved or as other changes in circumstances occur, and if necessary, will adjust its estimate of the transaction price to include milestones as they become probable of occurrence.

Allocation of Transaction Price to Performance Obligations

The Company allocated the transaction price to each performance obligation on a relative estimated standalone selling price basis. The Company developed the estimated standalone selling price for the GS-1811 License based on the present value of expected future cash flows associated with the license and related clinical development and regulatory milestones. In developing such estimate, the Company applied judgement in determining the timing needed to develop the Licensed Product, the probability of success, and the discount rate. The Company developed the estimated standalone selling price for the Research and Transition Services obligation based on the nature of the services to be performed and the Company’s best estimate of the length of time required to perform the services necessary to achieve clearance of an IND application for the GS-1811 program.

Based on the above considerations, $3.5 million of the initial transaction price was allocated to the Research and Transition Services performance obligation.

Recognition of Revenue

The Company determined that the GS-1811 License is a functional license as the underlying IP has significant standalone functionality. In addition, the Company determined that October 16, 2020 represents (i) the date at which the Company made available the IP to Gilead and (ii) the beginning of the period during which Gilead is able to use and benefit from its right to use the IP. Based upon these considerations, the Company recognized the entirety of the initial transaction price allocated to the GS-1811 License performance obligation during the year ended December 31, 2020.

Further, the Company determined the input method under ASC 606 is the most appropriate method of revenue recognition for the Research and Transition Services performance obligation. The method of measuring progress towards delivery of the services incorporated actual internal and external costs incurred, relative to total internal and external costs expected to be incurred to satisfy the performance obligation. The period over which total costs were estimated reflected the Company’s best

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estimate of the period over which it would perform the Research and Transition Services to achieve clearance of an IND application of the GS-1811 program and transition the program to Gilead.

No revenue was recognized under the contract during the three and nine months ended September 30, 2022 as all remaining performance obligations were satisfied during the year ended December 31, 2021. During the nine months ended September 30, 2021, the Company recognized $26.9 million of license and collaboration revenue related to achievement of a $25.0 million clinical development and regulatory milestone for FDA clearance of the IND for GS-1811 and $1.9 million related to the completion of Research and Transition Services. No revenue was recognized during the three months ended September 30, 2021.

4.    Fair Value Measurements

Fair value is an exit price, representing the amount that would be received from the sale of an asset or paid to transfer a liability in an orderly transaction between market participants. Fair value is determined based on observable and unobservable inputs. Observable inputs reflect readily obtainable data from independent sources, while unobservable inputs reflect certain market assumptions. As a basis for considering such assumptions, GAAP establishes a three-tier value hierarchy, which prioritizes the inputs used to develop the assumptions and for measuring fair value as follows: (Level 1) observable inputs such as quoted prices in active markets for identical assets; (Level 2) inputs other than the quoted prices in active markets that are observable either directly or indirectly; and (Level 3) unobservable inputs in which there is little or no market data, which requires the Company to develop its own assumptions. This hierarchy requires the Company to use observable market data, when available, and to minimize the use of unobservable inputs when determining fair value.

The Company measures the fair value of money market funds, U.S. Treasuries and government agency securities based on quoted prices in active markets for identical securities. Investments also include corporate debt securities which are valued either based on recent trades of securities in inactive markets or based on quoted market prices of similar instruments and other significant inputs derived from or corroborated by observable market data.

The carrying amounts reflected in the condensed consolidated balance sheets for cash, prepaid expenses and other current assets, accounts payable and accrued expenses approximate their fair values, due to their short-term nature.

Assets measured at fair value on a recurring basis as of September 30, 2022 were as follows (in thousands):

	Total		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Money market funds, included in cash equivalents	$	77,111	$	77,111	$	—	$	—
Investments:
Corporate debt securities	21,419		—		21,419		—
U.S. Treasuries	24,066		24,066		—		—
Government agency securities	7,736		—		7,736		—
Totals	$	130,332	$	101,177	$	29,155	$	—

Assets measured at fair value on a recurring basis as of December 31, 2021 were as follows (in thousands):

	Total		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Money market funds, included in cash equivalents	$	95,529	$	95,529	$	—	$	—
Investments:
Corporate debt securities	86,470		—		86,470		—
U.S. Treasuries	30,271		30,271		—		—
Government agency securities	7,953		—		7,953		—
Totals	$	220,223	$	125,800	$	94,423	$	—

There were no changes in valuation techniques during the nine months ended September 30, 2022 or during the year ended December 31, 2021. There were no liabilities measured at fair value on a recurring basis as of September 30, 2022 or December 31, 2021.

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5.     Investments

Short-term investments consist of investments with maturities greater than ninety days and less than one year from the balance sheet date. Long-term investments consist of investments with maturities of greater than one year that are not expected to be used to fund current operations. The Company classifies all of its investments as available-for-sale securities. Accordingly, these investments are recorded at fair value. Realized gains and losses, amortization and accretion of discounts and premiums are included in other income, net. Unrealized gains and losses on available-for-sale securities are included in other comprehensive income as a component of stockholders’ equity until realized.

Cash equivalents, short-term investments and long-term investments as of September 30, 2022 were comprised as follows (in thousands):

	September 30, 2022
	Amortized Cost		Unrealized Gains		Unrealized Losses		Fair Value
Cash equivalents and short-term investments:
Money market funds, included in cash equivalents	$	77,111	$	—	$	—	$	77,111
Corporate debt securities	21,741		—		(322)		21,419
U.S. Treasuries	24,559		—		(493)		24,066
Government agency securities	6,158		—		(145)		6,013
Total cash equivalents and short-term investments	129,569		—		(960)		128,609
Long-term investments:
Government agency securities	1,794		—		(71)		1,723
Total long-term investments	1,794		—		(71)		1,723
Total cash equivalents and investments	$	131,363	$	—	$	(1,031)	$	130,332

Cash equivalents, short-term investments and long-term investments as of December 31, 2021 were comprised as follows (in thousands):

	December 31, 2021
	Amortized Cost		Unrealized Gains		Unrealized Losses		Fair Value
Cash equivalents and short-term investments:
Money market funds, included in cash equivalents	$	95,529	$	—	$	—	$	95,529
Corporate debt securities	69,316		—		(34)		69,282
U.S. Treasuries	13,777		—		(22)		13,755
Total cash equivalents and short-term investments	178,622		—		(56)		178,566
Long-term investments:
Corporate debt securities	17,276		—		(88)		17,188
U.S. Treasuries	16,580		—		(64)		16,516
Government agency securities	7,983		—		(30)		7,953
Total long-term investments	41,839		—		(182)		41,657
Total cash equivalents and investments	$	220,461	$	—	$	(238)	$	220,223

As of September 30, 2022 and December 31, 2021, the aggregate fair value of securities that were in an unrealized loss position for less than twelve months was $39.2 million and $86.7 million, respectively. As of September 30, 2022 and December 31, 2021, the aggregate fair value of securities that were in an unrealized loss position for more than twelve months was $14.0 million and $4.8 million, respectively. As of September 30, 2022, the Company did not intend to sell, and would not be more likely than not required to sell, the securities in an unrealized loss position before recovery of their amortized cost bases. Furthermore, the Company determined that there was no material change in the credit risk of these securities. As a result, the Company determined it did not hold any securities with any other-than-temporary impairment as of September 30, 2022.

There were no realized gains or losses on available-for-sale securities during the three or nine months ended September 30, 2022 or September 30, 2021.

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6.     Restricted Cash

As of both September 30, 2022 and December 31, 2021, the Company maintained non-current restricted cash of $1.3 million. This amount is included within “Other non-current assets” in the accompanying condensed consolidated balance sheets and is comprised solely of a security deposit required pursuant to the lease for the Company’s corporate headquarters.

The following table provides a reconciliation of cash, cash equivalents and restricted cash that sums to the total of the same such amounts shown in the condensed consolidated statements of cash flows (in thousands):

	Nine Months Ended September 30, 2022				Nine Months Ended September 30, 2021
	Beginning of Period		End of Period		Beginning of Period		End of Period
Cash and cash equivalents	$	95,529	$	77,111	$	147,493	$	145,365
Restricted cash	1,270		1,270		1,270		1,270
Cash, cash equivalents and restricted cash	$	96,799	$	78,381	$	148,763	$	146,635

7.     Accrued Expenses

Accrued expenses as of September 30, 2022 and December 31, 2021 were comprised as follows (in thousands):

	September 30,		December 31,
	2022		2021
External research, development and professional services	$	9,749	$	6,252
Employee compensation and benefits	6,435		6,844
Lab consumables and other	420		371
Total accrued expenses	$	16,604	$	13,467

8.   Common Stock and Preferred Stock

Common Stock

The Company is authorized to issue 160,000,000 shares of common stock. Holders of common stock are entitled to one vote per share. Holders of common stock are entitled to receive dividends, if and when declared by the board of directors.

On December 17, 2019, the Company entered into a Sales Agreement (the “2019 Sales Agreement”) with Cowen and Company, LLC (“Cowen”) pursuant to which the Company could offer and sell shares of its common stock with an aggregate offering price of up to $50.0 million under an “at the market” (“ATM”) offering program (the “2019 ATM Offering”). The 2019 Sales Agreement provided that Cowen would be entitled to a sales commission equal to 3.0% of the gross sales price per share of all shares sold under the 2019 ATM Offering. During the first quarter of 2021, the Company sold an aggregate of 3,156,200 shares at an average price of $9.87 per share for net proceeds of $30.2 million, which completed the sale of all available amounts under the 2019 ATM Offering.

In addition, during the first quarter of 2021, the Company completed a follow-on public offering of its common stock, selling an aggregate of 5,750,000 shares of common stock at a public offering price of $11.25 per share for net proceeds of $60.6 million, after deducting underwriting discounts and commissions and offering fees.

On November 4, 2021, the Company entered into a new Sales Agreement with Cowen (the “2021 Sales Agreement”), pursuant to which the Company may offer and sell shares of its common stock with an aggregate offering price of up to $75.0 million under an ATM offering program (the “2021 ATM Offering”). The 2021 Sales Agreement provides that Cowen will be entitled to a sales commission equal to 3.0% of the gross sales price per share of all shares sold under the 2021 ATM Offering. No sales have been made under the 2021 ATM Offering.

Preferred Stock

The Company is authorized to issue 5,000,000 shares of undesignated preferred stock in one or more series. As of September 30, 2022 and December 31, 2021, no shares of preferred stock were issued or outstanding.

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Shares Reserved for Future Issuance

As of September 30, 2022 and December 31, 2021, the Company had reserved for future issuance the following number of shares of common stock (in thousands):

	September 30,	December 31,
	2022	2021
Shares reserved for vesting of restricted stock units	1,016	833
Shares reserved for exercises of outstanding stock options	8,592	7,629
Shares reserved for future issuance under the 2017 Stock Option and Incentive Plan	1,734	1,258
Total shares reserved for future issuance	11,342	9,720

9.   Stock-based Compensation

2013 Stock Option and Grant Plan

In February 2013, the board of directors adopted and the Company’s stockholders approved the 2013 Stock Option and Grant Plan (the “2013 Plan”), as amended and restated, under which it could grant incentive stock options (“ISOs”), non-qualified stock options, restricted stock awards (“RSAs”) and restricted stock units (“RSUs”) to eligible employees, officers, directors, and consultants. The 2013 Plan was subsequently amended in January 2015, April 2015, July 2015, March 2016 and October 2016 to allow for the issuance of additional shares of common stock.

2017 Stock Option and Incentive Plan

In January 2017, the board of directors adopted and the Company’s stockholders approved the 2017 Stock Option and Incentive Plan (the “2017 Plan”). Upon the adoption of the 2017 Plan, no further awards will be granted under the 2013 Plan.

The 2017 Plan provides for the grant of ISOs, non-qualified stock options, RSAs, RSUs, stock appreciation rights and other stock-based awards. The Company’s employees, officers, directors and consultants and advisors are eligible to receive awards under the 2017 Plan. The terms of awards, including vesting requirements, are determined by the board of directors, subject to the provisions of the 2017 Plan.

The Company initially registered on Form S-8 1,753,758 shares of common stock under the 2017 Plan, which was comprised of (i) 1,510,000 shares of common stock reserved for issuance under the 2017 Plan, plus (ii) 243,758 shares of common stock originally reserved for issuance under the 2013 Plan that became available for issuance under the 2017 Plan upon the completion of the Company’s IPO. The 2017 Plan also provides that an additional number of shares will automatically be added to the shares authorized for issuance under the 2017 Plan on January 1, 2018 and each January 1st thereafter. The number of shares added each year will be equal to the lesser of (i) 4% of the outstanding shares on the immediately preceding December 31st or (ii) such amount as determined by the compensation committee of the board of directors. Effective January 1, 2021 and 2022, 1,669,162 and 2,050,601 additional shares, respectively, were automatically added to the shares authorized for issuance under the 2017 Plan.

As of September 30, 2022, there were 1,733,603 shares available for future issuance under the 2017 Plan.

Inducement Stock Options

The Company may grant, upon approval by the compensation committee of the board of directors, awards, including options to purchase shares of common stock, as an inducement to employment in accordance with Nasdaq Listing Rule 5635(c)(4). The securities are issued pursuant to Section 4(a)(2) under the Securities Act of 1933, as amended, relating to transactions by an issuer not involving any public offering. These options are subject to substantially the same terms as options issued pursuant to the 2017 Plan. During the second quarter of 2021, the Company granted an option to purchase 225,000 shares of common stock as an inducement award.

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2017 Employee Stock Purchase Plan

In January 2017, the board of directors adopted and the Company’s stockholders approved the 2017 Employee Stock Purchase Plan (the “2017 ESPP”). The Company initially reserved 302,000 shares of common stock for future issuance under the 2017 ESPP. The 2017 ESPP also provides that an additional number of shares will automatically be added to the shares authorized for issuance under the 2017 ESPP on January 1, 2018 and each January 1st thereafter through January 1, 2027. The number of shares added each year will be equal to the lesser of (i) 1% of the outstanding shares on the immediately preceding December 31st, (ii) 603,000 shares or (iii) such amount as determined by the compensation committee of the board of directors. Effective January 1, 2021 and 2022, 417,291 and 512,650 additional shares, respectively, were automatically added to the shares authorized for issuance under the 2017 ESPP. No offering periods under the 2017 ESPP had been initiated as of September 30, 2022.

Stock-based Compensation Expense

Total stock-based compensation expense recognized in the condensed consolidated statements of operations and comprehensive loss for the three and nine months ended September 30, 2022 and 2021 was as follows (in thousands):

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Research and development	$	1,254	$	1,628	$	3,913	$	4,129
General and administrative	1,306		1,298		3,919		4,557
Total stock-based compensation expense	$	2,560	$	2,926	$	7,832	$	8,686

RSU Activity

The Company has also granted RSUs to its employees under the 2017 Plan. The following table summarizes RSU activity for the nine months ended September 30, 2022 (in thousands, except per share amounts):

	RSUs	Weighted-Average Grant Date Fair Value per Share
Unvested as of December 31, 2021	833	$	9.13
Issued	670	$	7.25
Vested	(358)	$	8.15
Cancelled	(129)	$	8.59
Unvested as of September 30, 2022	1,016	$	8.31

The aggregate fair value of RSUs that vested during the three and nine months ended September 30, 2022, based upon the fair values of the stock underlying the RSUs on the day of vesting, was less than $0.1 million and $2.7 million, respectively. The aggregate fair value of RSUs that vested during the three and nine months ended September 30, 2021, based upon the fair values of the stock underlying the RSUs on the day of vesting, was less than $0.1 million and $1.5 million, respectively.

As of September 30, 2022, there was unrecognized stock-based compensation expense related to unvested RSUs of $5.5 million, which the Company expects to recognize over a weighted-average period of approximately 1.7 years.

Stock Option Activity

The fair value of stock options granted during the three and nine months ended September 30, 2022 and 2021 was calculated on the date of grant using the following weighted-average assumptions:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Risk-free interest rate	2.9	%	1.0	%	2.0	%	0.8	%
Expected dividend yield	—	%	—	%	—	%	—	%
Expected term (in years)	6.1		6.1		6.0		6.0
Expected volatility	80.7	%	82.0	%	80.9	%	81.9	%

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Using the Black-Scholes option pricing model, the weighted-average grant date fair value of stock options granted during the three months ended September 30, 2022 and 2021 was $2.20 per share and $4.24 per share, respectively. The weighted-average grant date fair value of stock options granted during the nine months ended September 30, 2022 and 2021 was $4.57 per share and $7.22 per share, respectively.

The following table summarizes stock option activity during the nine months ended September 30, 2022 (in thousands, except per share amounts):

	Options	Weighted-Average Exercise Price		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value
Outstanding at December 31, 2021	7,629	$	8.87	6.4	$	16,881
Granted	1,747	$	6.57
Exercised	(71)	$	5.49
Cancelled	(713)	$	9.29
Outstanding at September 30, 2022	8,592	$	8.39	6.4	$	1,255
Exercisable at September 30, 2022	5,751	$	8.77	5.1	$	1,255

No stock options were exercised during the three months ended September 30, 2022. The aggregate intrinsic value of stock options exercised during the three months ended September 30, 2021 was less than $0.1 million. The aggregate intrinsic value of stock options exercised during the nine months ended September 30, 2022 and 2021 was $0.1 million and $2.9 million, respectively.

As of September 30, 2022, there was unrecognized stock-based compensation expense related to unvested stock options of $13.5 million, which the Company expects to recognize over a weighted-average period of approximately 2.5 years.

10.   Related-party Transactions

In August 2020, the Company entered into the Gilead License Agreement and Stock Purchase Agreement under which it received a non-refundable upfront payment of $85.0 million and cash consideration of $35.0 million for Gilead’s purchase of 5,539,727 shares of the Company’s common stock. As of September 30, 2022, the Company had no reimbursable expenses due from Gilead.

11.   Net Loss per Share

For purposes of the diluted net loss per share calculation, outstanding stock options and unvested RSUs are considered to be potentially dilutive securities, however the following weighted-average amounts were excluded from the calculation of diluted net loss per share because their effect would be anti-dilutive (in thousands):

	Three Months Ended September 30,		Nine Months Ended September 30,
	2022	2021	2022	2021
Outstanding stock options	8,646	7,559	8,567	7,284
Unvested RSUs	999	822	981	771
Total	9,645	8,381	9,548	8,055

12.   Subsequent Events

In October 2022, the Company earned a $15.0 million clinical development and regulatory milestone associated with GS-1811 under the Gilead License Agreement. The Company expects to receive the milestone payment in the fourth quarter of 2022.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion and analysis of our financial condition and results of operations should be read together with our condensed consolidated financial statements and related notes appearing elsewhere in this Quarterly Report on Form 10-Q and our Annual Report on Form 10-K for the year ended December 31, 2021 that was filed with the United States Securities and Exchange Commission, or the SEC, on March 2, 2022. In addition to historical information, this discussion and analysis contains forward-looking statements that involve risks, uncertainties and assumptions. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of certain factors. We discuss factors that we believe could cause or contribute to these differences below and elsewhere in this Quarterly Report on Form 10-Q, including those factors set forth in the section entitled “Cautionary Note Regarding Forward-Looking Statements and Industry Data,” and in the sections entitled “Summary of Risk Factors” and “Risk Factors” in Part I, Item 1A of our Annual Report on Form 10-K for the year ended December 31, 2021.

Overview

We are a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients. Our strategy is to use a biomarker-driven approach from discovery through clinical development. We have developed a suite of integrated technologies that comprise our Translational Science Platform, enabling us to comprehensively interrogate the cellular and molecular composition of tumors. By focusing on specific cell types, both immune and non-immune, within tumors, we can prioritize targets and then identify related biomarkers designed to match the right therapy to the right patient. Our pipeline is focused on product candidates to address PD-(L)1 inhibitor resistant and PD-(L)1 inhibitor sensitive tumors, which represent significant opportunities requiring different biological approaches. We aim to develop product candidates that address the unmet medical need of patients in both of these populations.

Our highest priority program, JTX-8064, is being developed for patients with either PD-(L)1 inhibitor resistant or PD-(L)1 inhibitor sensitive tumors. JTX-8064 is the first tumor-associated macrophage candidate to emerge from our Translational Science Platform. JTX-8064 is a monoclonal antibody that binds to Leukocyte Immunoglobulin Like Receptor B2, or LILRB2 (also known as ILT4), which is a cell surface receptor expressed on macrophages and other myeloid cells. Our INNATE clinical trial is a Phase 1/2 clinical trial of JTX-8064 as a monotherapy and in combination with our PD-1 inhibitor, pimivalimab, in patients with solid tumors. In 2021, we completed the Phase 1 dose-escalation portions of the INNATE trial for both monotherapy and combination therapy, and initiated enrollment in the Phase 2 monotherapy and combination therapy portions. We selected 700 mg as our recommended Phase 2 dose for further evaluation. JTX-8064 has been well-tolerated to date with no observed dose limiting toxicities. The Phase 2 portion of the INNATE trial is comprised of one monotherapy and eight combination indication-specific expansion cohorts, including a recently-opened eighth cohort in second/third line PD-(L)1 inhibitor resistant biliary tract cancer, or BTC. The trial is designed to demonstrate proof-of-concept and, once proof-of-concept is established, we plan to move JTX-8064 into randomized trials on a cohort-by-cohort basis.

The expansion cohorts are studying tumor types in three groups of patients: (i) PD-(L)1 inhibitor experienced patients whose tumors progressed on or after treatment with a PD-(L)1 inhibitor (including non-small cell lung cancer, or NSCLC), (ii) PD-(L)1 inhibitor naïve patients whose tumors are historically resistant to PD-(L)1 inhibitors (including ovarian cancer), and (iii) PD-(L)1 inhibitor naïve patients whose tumors are historically more sensitive to PD-(L)1 inhibitors (including front line PD-L1 positive head and neck squamous cell carcinoma, or HNSCC). Each Phase 2, proof-of-concept expansion cohort is designed as a Simon’s 2 stage. Once the first stage of a cohort meets prespecified response criteria to further expand, the second stage may open and enroll additional patients. Three of our Phase 2 combination cohorts have met prespecified criteria to continue expansion. Third/fourth line platinum resistant PD-(L)1 inhibitor naive ovarian and second/third line PD-(L)1 inhibitor experienced clear cell renal cell carcinoma have expanded, and second/third line PD-(L)1 inhibitor experienced HNSCC is currently under review for expansion. We believe we have seen signs of clinical activity of JTX-8064 but not broad activity leading to rapid proof-of-concept. We plan to report clinical data on all Phase 1 dose escalation patients at the ESMO Immuno-Oncology Annual Congress in December 2022. We expect to share preliminary clinical data for Phase 2 patients in the first half of 2023. We also expect to report on the analysis of association of clinical data and a predefined set of potential predictive biomarkers.

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Vopratelimab is a clinical-stage monoclonal antibody that binds to and activates the Inducible T cell CO-Stimulator, or ICOS, a protein on the surface of certain T cells commonly found in many solid tumors. The SELECT trial is a randomized Phase 2 proof-of-concept trial outside the United States evaluating two doses of vopratelimab in combination with pimivalimab compared to pimivalimab alone in biomarker-selected, second-line, PD-(L)1 inhibitor naive NSCLC patients. We identified patients for SELECT using TISvopra, an 18 gene signature that includes genes relevant to both CD8 and CD4 T cell biology. TISvopra has been optimized to predict for emergence of ICOS hi CD4 T cells in the peripheral blood, which have been associated with clinical benefit in patients treated with vopratelimab alone or in combination with nivolumab. The two doses under investigation have different patterns of pulsatile target engagement, which we believe may be important for an agonist antibody. Although, as we announced in August 2022, the trial did not meet the primary endpoint for the combined dose cohorts and will not be expanded into registrational studies at this time, we believe the results for the low dose cohort are encouraging. In addition, there is preclinical data and biologic rationale for improved activity with pulsatile target engagement by an agonist. As the progression free survival and overall survival data continue to mature, we plan to reevaluate the vopratelimab program in the context of our broader pipeline.

Pimivalimab is a clinical-stage anti-PD-1 monoclonal antibody that we are developing primarily for use in combination with our product candidates, as we believe that combination therapy has the potential to be a mainstay of cancer immunotherapy. We presented safety and preliminary efficacy data from our monotherapy Phase 1 clinical trial of pimivalimab in 2019. Based on the results of that clinical trial, we are using pimivalimab in combination with JTX-8064 in INNATE and vopratelimab in SELECT. In August 2022, in connection with our announcement of our top line data for SELECT, we reported that pimivalimab monotherapy continues to demonstrate expected clinical activity and have an acceptable safety profile.

GS-1811, formerly JTX-1811, is our fourth internally developed program to enter the clinic, and we have transitioned the program to Gilead Sciences, Inc., or Gilead. In August 2020, we entered into an agreement to exclusively license GS-1811 to Gilead. GS-1811 is a monoclonal antibody that is designed to selectively deplete T regulatory cells in the tumor microenvironment, or TME, by targeting a receptor called CCR8, which is preferentially expressed on intra-tumoral T regulatory cells. Pursuant to our exclusive license agreement with Gilead, or the Gilead License Agreement, we granted Gilead a worldwide license to develop, manufacture and commercialize GS-1811 and certain derivatives thereof, as well as backup antibodies defined within the agreement. Gilead initiated a clinical trial of GS-1811 in August 2021.

JTX-1484 is the most recent product candidate to emerge from our Translational Science Platform. JTX-1484 is a monoclonal antibody designed to block human Leukocyte Immunoglobulin Like Receptor B4, or LILRB4 (also known as ILT3), on various myeloid cells which we believe may lead to reduced immune suppression and enhancement of T cell functionality. We are currently conducting investigational new drug application, or IND, enabling activities for JTX-1484, with the goal of submitting an IND in 2023.

With our biomarker-driven approach, we leverage our Translational Science Platform to interrogate cell types within the human TME and to identify and prioritize targets across a broad spectrum of immune and non-immune cell types. In addition, early in the development process, we use our Translational Science Platform to identify potential predictive biomarkers to enable us to enrich our clinical trials for patient populations that may be more likely to respond to a particular immunotherapy. Once clinical data is available for a product candidate, we then use a reverse translational approach to interrogate tumor and blood samples from patients with known outcomes. By using these reverse translational findings, we believe we are better able to design clinical trials and more efficiently develop cancer immunotherapies that potentially provide greater benefit to patients. We believe these biomarker results, coordinated to clinical response, will assist with isolating the contribution of our cancer immunotherapies to clinical activity in a combination therapy setting. These biomarker results may also assist with identifying a potential companion diagnostic and/or complementary diagnostic for a given therapy.

Beyond our product candidates, we continue to advance and build our discovery pipeline. We are discovering and developing next-generation immunotherapies by leveraging our Translational Science Platform to systematically and comprehensively interrogate cell types within the tumor microenvironment. Our broad discovery pipeline includes multiple programs targeting myeloid cells such as macrophages, T regulatory cells and non-immune cells. We believe that the use of our Translational Science Platform to efficiently identify novel immuno-oncology targets and advance them from discovery to IND stage is a sustainable approach that we plan to continually apply across our broad discovery pipeline and target selection process.

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Since inception, our operations have focused on organizing and staffing our Company, business planning, raising capital, developing our Translational Science Platform and conducting research, preclinical studies and clinical trials. We do not have any products approved for sale. We are subject to a number of risks comparable to those of other similar companies, including dependence on key individuals; the need to develop commercially viable products; competition from other companies, many of which are larger and better capitalized; and the need to obtain adequate additional financing to fund the development of our products. We have funded our operations primarily through proceeds received from public offerings and private placements of our stock totaling $389.5 million and payments from collaboration and license agreements totaling $385.0 million. These amounts exclude a $15.0 million clinical development and regulatory milestone achieved in October 2022 under the Gilead License Agreement.

Due to our significant research and development expenditures, we have accumulated substantial losses since our inception. As of September 30, 2022, we had an accumulated deficit of $343.8 million. We expect to incur substantial additional losses in the future as we continue to advance our programs.

We continue to actively monitor the COVID-19 pandemic and its impact on our business. As of November 10, 2022, we have not experienced a significant financial impact directly related to the COVID-19 pandemic but have experienced some disruptions to clinical operations and to our supply chain. As the pandemic and its consequences continue, the extent of its effect on our operational and financial performance will depend in large part on future developments, which cannot be predicted with confidence at this time.

Financial Operations Overview

Revenue

For the nine months ended September 30, 2022, we did not recognize any license or collaboration revenue. For the nine months ended September 30, 2021, we recognized $26.9 million of license and collaboration revenue under the Gilead License Agreement for achievement of a clinical development and regulatory milestone of $25.0 million relating to the GS-1811 program and $1.9 million for the performance of research and transition services.

In the future, we may generate revenue from product sales, collaboration agreements, strategic alliances or licensing arrangements, including potential milestone payments and royalties under the Gilead License Agreement. We expect that our revenue will fluctuate from quarter-to-quarter and year-to-year as a result of the timing and amount of license fees, milestones, reimbursement of costs incurred and other payments, if any, and product sales, to the extent any products are successfully commercialized. If we or third parties fail to complete the development of our product candidates in a timely manner or obtain regulatory approval for them, our ability to generate future revenue, and our results of operations and financial position, could be materially adversely affected.

Operating Expenses

Research and Development Expenses

Research and development expenses represent costs incurred by us for the discovery, development and manufacture of our current and future product candidates and include: external research and development expenses incurred under arrangements with third parties, including contract research organizations, contract manufacturing organizations, academic and non-profit institutions and consultants; salaries and personnel-related costs, including non-cash stock-based compensation expense; license fees to acquire in-process technology; and other expenses, which include direct and allocated expenses for laboratory, facilities and other costs.

We use our employee and infrastructure resources across multiple research and development programs and for identifying, testing and developing product candidates from our Translational Science Platform. We manage certain activities such as contract research and manufacture of our product candidates and discovery programs through our third-party vendors.

At this time, we cannot reasonably estimate or know the nature, timing and estimated costs of the efforts that will be necessary to complete the development of our product candidates. We are also unable to predict when, if ever, material net cash inflows will commence from sales of our product candidates. This is due to the numerous risks and uncertainties associated with developing such product candidates, including the uncertainty of:

•addition and retention of key research and development personnel;

•establishing an appropriate safety profile with IND-enabling toxicology studies and clinical trials;

•the cost to acquire or make therapies to study in combination with our immunotherapies;

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•successful enrollment in and completion of clinical trials, including the impacts of the COVID-19 pandemic on the timing and progress of our ongoing and planned clinical trials;

•establishing agreements with third-party contract manufacturing organizations for clinical supply for our clinical trials and commercial manufacturing, if our product candidates are approved;

•receipt of marketing approvals from applicable regulatory authorities;

•commercializing products, if and when approved, whether alone or in collaboration with others;

•the cost to develop companion diagnostics and/or complementary diagnostics as needed for each of our development programs;

•the costs associated with the development of any additional product candidates we acquire through third-party collaborations or identify through our Translational Science Platform;

•the terms and timing of any collaboration, license or other arrangement, including any milestone payments thereunder;

•obtaining and maintaining patent and trade secret protection and regulatory exclusivity for our products, if and when approved; and

•continued acceptable safety profiles of the products following approval.

A change in the outcome of any of these variables with respect to the development of any of our product candidates would significantly change the costs, timing and viability associated with the development of that product candidate. As we plan to advance our product candidates through clinical trials, continue the enhancement of our Translational Science Platform and progress our pipeline, we expect to continue to incur significant research and development expenses for the foreseeable future.

Due to the inherently unpredictable nature of preclinical and clinical development, we do not allocate all of our internal research and development expenses on a program-by-program basis as they primarily relate to personnel and lab consumables costs that are deployed across multiple programs under development. Our research and development expenses also include external costs, which we track on a program-by-program basis following a program’s nomination as a development candidate. We began incurring such external costs for vopratelimab in 2015, pimivalimab in 2016, JTX-8064 in 2017, GS-1811 in 2019 and JTX-1484 in 2021.

Included below are external research and development and external clinical and regulatory costs for our development and pre-development candidates for the three and nine months ended September 30, 2022 and 2021:

	Three Months Ended September 30,				Nine Months Ended September 30,
(in thousands)	2022		2021		2022		2021
JTX-8064	$	6,615	$	6,220	$	23,612	$	13,413
Vopratelimab	2,339		4,414		9,737		13,433
Pimivalimab	188		860		5,184		2,122
JTX-1484	1,088		—		1,592		—
GS-1811	—		59		—		2,535
Pre-development candidates	1,200		613		2,178		1,267
Total external research and development and clinical and regulatory costs	$	11,430	$	12,166	$	42,303	$	32,770

Research and development activities account for a significant portion of our operating expenses. We expect to incur significant research and development expenses over the next several years as we implement our current business strategy and:

•continue our development of JTX-8064, including our INNATE trial and in combination with pimivalimab;

•continue advancing programs through IND-enabling activities;

•continue to identify and develop potential predictive biomarkers and companion diagnostics and/or complementary diagnostics for our product candidates; and

•continue to develop and enhance our Translational Science Platform and advance our pipeline of immunotherapy programs and our early research activities into IND-enabling activities.

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Product candidates in later stages of clinical development generally incur higher development costs than those in earlier stages of clinical development, primarily due to the increased size and duration of later-stage clinical trials.

General and Administrative Expenses

General and administrative expenses consist of salaries and personnel-related costs, including non-cash stock-based compensation expense, for our personnel in executive, business development, legal, finance and accounting, human resources and other administrative functions, consulting fees, facility costs not otherwise included in research and development expenses, fees paid for accounting and tax services, insurance expenses and legal costs. Legal costs include general corporate legal fees, patent legal fees and related costs. We anticipate that our general and administrative expenses will increase in the future to support our continued operations.

Other Income, Net

Other income, net, consists primarily of interest and investment income on our cash, cash equivalents and investments.

Results of Operations

Comparison of the Three Months Ended September 30, 2022 and 2021

The following table summarizes our results of operations for the three months ended September 30, 2022 and 2021:

	Three Months Ended September 30,
(in thousands)	2022		2021		$ Change
Revenue:
License and collaboration revenue — related party	$	—	$	—	$	—
Operating expenses:
Research and development	23,752		23,288		464
General and administrative	7,653		6,854		799
Total operating expenses	31,405		30,142		1,263
Operating loss	(31,405)		(30,142)		(1,263)
Other income, net	412		55		357
Loss before provision for income taxes	(30,993)		(30,087)		(906)
Provision for income taxes	5		6		(1)
Net loss	$	(30,998)	$	(30,093)	$	(905)

License and Collaboration Revenue

For the three months ended September 30, 2022 and 2021 we did not recognize any license and collaboration revenue.

Research and Development Expenses

The following table summarizes our research and development expenses for the three months ended September 30, 2022 and 2021:

	Three Months Ended September 30,
(in thousands)	2022		2021		$ Change
Employee compensation	$	8,141	$	7,893	$	248
External clinical and regulatory	6,292		7,503		(1,211)
External research and development	5,138		4,663		475
Lab consumables	2,460		1,429		1,031
Facility costs	1,159		1,319		(160)
Other research	562		481		81
Total research and development expenses	$	23,752	$	23,288	$	464

Research and development expenses increased by $0.5 million from $23.3 million for the three months ended September 30, 2021 to $23.8 million for the three months ended September 30, 2022. The increase in research and development expenses was primarily attributable to the following:

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•$1.0 million of increased lab consumables to support research activities; and

•$0.5 million of increased external research and development costs associated with manufacturing activities for our development programs; offset by

•$1.2 million of decreased external clinical and regulatory costs for our vopratelimab development program.

General and Administrative Expenses

The following table summarizes our general and administrative expenses for the three months ended September 30, 2022 and 2021:

	Three Months Ended September 30,
(in thousands)	2022		2021		$ Change
Employee compensation	$	4,004	$	3,506	$	498
Professional services	1,298		1,112		186
Facility costs	1,016		1,002		14
Other	1,335		1,234		101
Total general and administrative expenses	$	7,653	$	6,854	$	799

General and administrative expenses increased by $0.8 million from $6.9 million for the three months ended September 30, 2021 to $7.7 million for the three months ended September 30, 2022. The increase in general and administrative expenses was primarily attributable to increased compensation costs due to increased headcount for the three months ended September 30, 2022.

Other Income, net

Other income, net, increased by less than $0.4 million from $0.1 million for the three months ended September 30, 2021 to $0.4 million for the three months ended September 30, 2022. The increase in other income, net is attributable to increased rates of return on our investments.

Comparison of the Nine Months Ended September 30, 2022 and 2021

The following table summarizes our results of operations for the nine months ended September 30, 2022 and 2021:

	Nine Months Ended September 30,
(in thousands)	2022		2021		$ Change
Revenue:
License and collaboration revenue — related party	$	—	$	26,907	$	(26,907)
Operating expenses:
Research and development	80,070		65,895		14,175
General and administrative	22,511		21,786		725
Total operating expenses	102,581		87,681		14,900
Operating loss	(102,581)		(60,774)		(41,807)
Other income, net	721		144		577
Loss before provision for income taxes	(101,860)		(60,630)		(41,230)
Provision for income taxes	18		9		9
Net loss	$	(101,878)	$	(60,639)	$	(41,239)

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License and Collaboration Revenue

For the nine months ended September 30, 2022, we did not recognize any license or collaboration revenue. For the nine months ended September 30, 2021, we recognized $26.9 million of license and collaboration revenue under the Gilead License Agreement related to achievement of a $25.0 million clinical development and regulatory milestone for FDA clearance of the IND for GS-1811 and $1.9 million related to the completion of research and transition services.

Research and Development Expenses

The following table summarizes our research and development expenses for the nine months ended September 30, 2022 and 2021:

	Nine Months Ended September 30,
(in thousands)	2022		2021		$ Change
Employee compensation	$	25,808	$	23,180	$	2,628
External research and development	21,744		13,089		8,655
External clinical and regulatory	20,559		19,681		878
Lab consumables	6,799		4,448		2,351
Facility costs	3,570		4,008		(438)
Other research	1,590		1,489		101
Total research and development expenses	$	80,070	$	65,895	$	14,175

Research and development expenses increased by $14.2 million from $65.9 million for the nine months ended September 30, 2021 to $80.1 million for the nine months ended September 30, 2022. The increase in research and development expenses was primarily attributable to the following:

•$8.7 million of increased external research and development costs associated with manufacturing for our development programs;

•$2.6 million of increased employee compensation costs primarily attributable to increased headcount;

•$2.4 million of increased lab consumables to support research activities; and

•$0.9 million of increased external clinical and regulatory costs primarily attributable to increased costs for our INNATE clinical trial; offset by

•$0.4 million of decreased depreciation expense.

General and Administrative Expenses

The following table summarizes our general and administrative expenses for the nine months ended September 30, 2022 and 2021:

	Nine Months Ended September 30,
(in thousands)	2022		2021		$ Change
Employee compensation	$	11,981	$	11,615	$	366
Professional services	3,497		3,527		(30)
Facility costs	3,022		3,079		(57)
Other	4,011		3,565		446
Total general and administrative expenses	$	22,511	$	21,786	$	725

General and administrative expenses increased by $0.7 million from $21.8 million for the nine months ended September 30, 2021 to $22.5 million for the nine months ended September 30, 2022. The increase in general and administrative expenses was primarily due to increased employee compensation costs primarily attributable to increased headcount, partially offset by reduced stock-based compensation expense, and due to increased other costs including travel and administrative expenses.

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Other Income, net

Other income, net, increased by $0.6 million from $0.1 million for the nine months ended September 30, 2021 to $0.7 million for the nine months ended September 30, 2022. The increase in other income, net is attributable to increased rates of return on our investments.

Liquidity and Capital Resources

Sources of Liquidity

We have funded our operations primarily through proceeds received from public offerings of our common stock and private placements of our common stock or convertible preferred stock totaling $389.5 million and payments from collaboration and license agreements totaling $385.0 million. These amounts exclude a $15.0 million clinical development and regulatory milestone achieved in October 2022 under the Gilead License Agreement. As of September 30, 2022, we had cash, cash equivalents and investments of $130.3 million.

On December 17, 2019, we entered into a Sales Agreement, or the 2019 Sales Agreement, with Cowen and Company, LLC, or Cowen, pursuant to which we could offer and sell shares of our common stock with an aggregate offering price of up to $50.0 million under an “at the market,” or ATM, offering program, or 2019 ATM Offering. The 2019 Sales Agreement provided that Cowen would be entitled to a sales commission equal to 3.0% of the gross sales price per share of all shares sold under the 2019 ATM Offering. During the first quarter of 2021, we sold an aggregate of 3,156,200 shares at an average price of $9.87 per share for net proceeds of $30.2 million, which completed the sale of all available amounts under the 2019 ATM Offering.

In addition, during the first quarter of 2021, we completed a follow-on public offering of our common stock, selling an aggregate of 5,750,000 shares of common stock at a public offering price of $11.25 per share for net proceeds of $60.6 million, after deducting underwriting discounts and commissions and offering fees.

On November 4, 2021, we entered into a new Sales Agreement with Cowen, or the 2021 Sales Agreement, pursuant to which we may offer and sell shares of our common stock with an aggregate offering price of up to $75.0 million under an ATM offering program, or 2021 ATM Offering. The 2021 Sales Agreement provides that Cowen will be entitled to a sales commission equal to 3.0% of the gross sales price per share of all shares sold under the 2021 ATM Offering. To date, no sales have been made under the 2021 ATM Offering.

Funding Requirements

Our plan of operation is to continue implementing our business strategy, the research and development of our current product candidates, our preclinical development activities, the expansion of our research pipeline and the enhancement of our internal research and development capabilities. Due to the inherently unpredictable nature of preclinical and clinical development and given the early stage of our programs and product candidates, we cannot reasonably estimate the costs we will incur and the timelines that will be required to complete development, obtain marketing approval, and commercialize our products, if and when approved. For the same reasons, we are also unable to predict when, if ever, we will generate revenue from product sales or whether, or when, if ever, we may achieve profitability. Clinical and preclinical development timelines, the probability of success, and development costs can differ materially from expectations. In addition, we cannot forecast which products, if and when approved, may be subject to future collaborations, when such arrangements will be secured, if at all, and to what degree such arrangements would affect our development plans and capital requirements.

Due to our significant research and development expenditures, we have generated substantial operating losses since inception. We have incurred an accumulated deficit of $343.8 million through September 30, 2022. We expect to incur substantial additional losses in the future as we continue to advance our programs. Based on our current research and development plans, we expect that our existing cash, cash equivalents and investments of $130.3 million as of September 30, 2022, will enable us to fund our operating expenses and capital expenditure requirements into the first quarter of 2024. However, we have based this estimate on assumptions that may prove to be incorrect, and we could exhaust our capital resources sooner than we expect. The timing and amount of our operating expenditures will depend largely on:

•the timing and progress of preclinical and clinical development activities, including the impacts of the COVID-19 pandemic on the timing and progress of our ongoing and planned clinical trials;

•the cost to access, acquire or develop therapies to study in combination with our immunotherapies;

•successful enrollment in and completion of clinical trials;

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•the cost to develop companion diagnostics and/or complementary diagnostics as needed for each of our development programs;

•our ability to establish agreements with third-party manufacturers for clinical supply for our clinical trials and, if any of our product candidates are approved, commercial manufacturing;

•the costs associated with the development of any additional product candidates we acquire through acquisition or third-party collaborations or identify through our Translational Science Platform;

•our ability to maintain our current research and development programs and enhancement of our Translational Science Platform;

•addition and retention of key research and development personnel;

•our efforts to enhance operational, financial and information management systems, and hire additional personnel, including personnel to support development of our product candidates;

•the legal patent costs involved in prosecuting patent applications and enforcing patent claims and other intellectual property claims;

•the costs and ongoing investments to in-license or acquire additional technologies, including the in-license of intellectual property related to our potential product candidates; and

•the terms and timing of any other collaboration, license or other arrangement, including the terms and timing of any option and milestone payments thereunder.

A change in the outcome of any of these or other variables with respect to the development of any of our product candidates could significantly change the costs and timing associated with the development of that product candidate. Furthermore, our operating plans may change in the future, and we may need additional funds to meet operational needs and capital requirements associated with such operating plans.

In addition to the variables described above, if and when any of our product candidates successfully complete development, we expect to incur substantial additional costs associated with regulatory filings, marketing approval, post-marketing requirements, maintaining our intellectual property rights, and regulatory protection, in addition to other costs. We cannot reasonably estimate these costs at this time.

Until such time, if ever, as we can generate substantial product revenue, we expect to finance our cash needs through a combination of equity or debt financings, collaborations, licensing arrangements and strategic alliances. We currently do not have a credit facility or committed sources of capital. To the extent that we raise additional capital through the future sale of equity or debt, the ownership interests of our stockholders will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of our existing common stockholders. If we raise additional funds through the issuance of debt securities, these securities could contain covenants that would restrict our operations. We may require additional capital beyond our currently anticipated amounts. Additional capital may not be available on reasonable terms, or at all. If we raise additional funds through collaboration arrangements in the future, we may have to relinquish valuable rights to our technologies, future revenue streams or product candidates, or grant licenses on terms that may not be favorable to us. If we are unable to raise additional funds through equity or debt financings when needed, we may be required to delay, limit, reduce, or terminate development or future commercialization efforts, or grant rights to develop and market product candidates that we would otherwise prefer to develop and market ourselves.

Cash Flows

The following table provides information regarding our cash flows for the nine months ended September 30, 2022 and 2021:

	Nine Months Ended September 30,
(in thousands)	2022		2021
Net cash (used in) provided by:
Operating activities	$	(88,111)	$	(55,293)
Investing activities	69,251		(38,830)
Financing activities	442		91,995
Net decrease in cash, cash equivalents and restricted cash	$	(18,418)	$	(2,128)

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Cash Used in Operating Activities

Net cash used in operating activities for the nine months ended September 30, 2022 was $88.1 million, compared to net cash used in operating activities of $55.3 million for the nine months ended September 30, 2021. Cash used in operating activities increased by $32.8 million due to increased net loss during the nine months ended September 30, 2022 driven by increased operating expenses and no revenue recognition under the Gilead License Agreement as compared to the nine months ended September 30, 2021.

Cash Provided by (Used in) Investing Activities

Net cash provided by investing activities for the nine months ended September 30, 2022 was $69.3 million, compared to net cash used in investing activities of $38.8 million for the nine months ended September 30, 2021. Cash provided by investing activities increased by $108.1 million due to decreased purchases of investments and timing of maturities for the nine months ended September 30, 2022 as compared to the nine months ended September 30, 2021.

Cash Provided by Financing Activities

Net cash provided by financing activities for the nine months ended September 30, 2022 was $0.4 million, compared to net cash provided by financing activities of $92.0 million for the nine months ended September 30, 2021. Cash provided by financing activities decreased by $91.6 million primarily due to proceeds of $90.8 million received from our follow-on public offering and 2019 ATM Offering completed during the first quarter of 2021 while no proceeds were received from financing facilities during the nine months ended September 30, 2022.

Critical Accounting Estimates

Our management’s discussion and analysis of our financial condition and results of operations is based on our condensed consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States. The preparation of these condensed consolidated financial statements requires us to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. On an ongoing basis, we evaluate our estimates which include, but are not limited to, accrued expenses, stock-based compensation expense and income taxes. We base our estimates on historical experience and other market specific or other relevant assumptions we believe to be reasonable under the circumstances. Actual results could differ from those estimates.

There were no material changes to our critical accounting estimates as reported in Item 7, Management’s Discussion and Analysis of Financial Condition and Results of Operations in our Annual Report on Form 10-K for the year ended December 31, 2021, which was filed with the SEC on March 2, 2022.

Item 3. Quantitative and Qualitative Disclosures about Market Risk

We are a smaller reporting company as defined by Rule 12b-2 of the Securities Exchange Act of 1934, or the Exchange Act, and are not required to provide the information under this item.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our principal executive officer and our principal financial officer, evaluated the effectiveness of our disclosure controls and procedures as of September 30, 2022. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, means controls and other procedures of a company that are designed to ensure that information required to be disclosed by the company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the Securities and Exchange Commission’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive and principal financial officers, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure. Our management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and our management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of our disclosure controls and procedures as of September 30, 2022, our principal executive officer and principal financial officer concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.

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Changes in Internal Control over Financial Reporting

There was no change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15(d)-15(f) under the Exchange Act) that occurred during the period covered by this Quarterly Report on Form 10-Q that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION

Item 1. Legal Proceedings

We are not currently a party to any material legal proceedings.

Item 1A. Risk Factors

In addition to the other information set forth in this Quarterly Report on Form 10-Q, you should carefully consider the factors discussed in Part I, Item 1A Risk Factors in our Annual Report on Form 10-K for the fiscal year ended December 31, 2021, which could materially affect our business, financial condition or future results.

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Item 6. Exhibits

Exhibit No.	Description of Exhibit
31.1*	Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
31.2*	Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
32.1+	Certifications of Principal Executive Officer and Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
101.INS*	Inline XBRL Instance Document (the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document)
101.SCH*	Inline XBRL Taxonomy Extension Schema Document
101.CAL*	Inline XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF*	Inline XBRL Taxonomy Extension Definition Linkbase Document
101.LAB*	Inline XBRL Taxonomy Extension Label Linkbase Document
101.PRE*	Inline XBRL Taxonomy Extension Presentation Linkbase Document
104	Cover Page Interactive Data File (formatted as Inline XBRL with applicable taxonomy extension information contained in Exhibits 101)
*	Filed herewith
+	Furnished herewith

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

		JOUNCE THERAPEUTICS, INC.
Date: November 10, 2022	By:	/s/ Kim C. Drapkin
		Kim C. Drapkin
		Treasurer and Chief Financial Officer
		(Principal Financial and Accounting Officer)

EX-31.1

Exhibit 31.1

CERTIFICATIONS

I, Richard Murray, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Jounce Therapeutics, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

    a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

    b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

    c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

    d. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

    a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

    b. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 10, 2022	By:	/s/ Richard Murray
		Richard Murray, Ph.D.
		President and Chief Executive Officer
		(Principal Executive Officer)

EX-31.2

Exhibit 31.2

CERTIFICATIONS

I, Kim C. Drapkin, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Jounce Therapeutics, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

    a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

    b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

    c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

    d. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

    a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

    b. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 10, 2022	By:	/s/ Kim C. Drapkin
		Kim C. Drapkin
		Treasurer and Chief Financial Officer
		(Principal Financial and Accounting Officer)

EX-32.1

Exhibit 32.1

CERTIFICATIONS OF CEO AND CFO PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with this Quarterly Report on Form 10-Q of Jounce Therapeutics, Inc. (the “Company”) for the period ended September 30, 2022, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), each of the undersigned officers of the Company hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of her or his knowledge:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: November 10, 2022	By:	/s/ Richard Murray
		Richard Murray, Ph.D.
		President and Chief Executive Officer
		(Principal Executive Officer)
Date: November 10, 2022	By:	/s/ Kim C. Drapkin
		Kim C. Drapkin
		Treasurer and Chief Financial Officer
		(Principal Financial and Accounting Officer)

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Cover Page - shares	9 Months Ended
	Sep. 30, 2022	Nov. 07, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Sep. 30, 2022
Document Transition Report	false
Entity File Number	001-37998
Entity Registrant Name	JOUNCE THERAPEUTICS, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	45-4870634
Entity Address, Address Line One	780 Memorial Drive
Entity Address, City or Town	Cambridge,
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02139
City Area Code	857
Local Phone Number	259-3840
Title of 12(b) Security	Common Stock, $0.001 par value per share
Trading Symbol	JNCE
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	true
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		51,694,237
Entity Central Index Key	0001640455
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q3
Amendment Flag	false

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Condensed Consolidated Balance Sheets (unaudited) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 77,111	$ 95,529
Short-term investments	51,498	83,037
Prepaid expenses and other current assets	11,321	12,261
Total current assets	139,930	190,827
Property and equipment, net	3,926	4,882
Long-term investments	1,723	41,657
Operating lease right-of-use asset	9,440	11,877
Other non-current assets	3,062	3,453
Total assets	158,081	252,696
Current liabilities:
Accounts payable	1,115	1,674
Accrued expenses	16,604	13,467
Operating lease liability, current	4,024	3,695
Other current liabilities	54	62
Total current liabilities	21,797	18,898
Operating lease liability, net of current portion	6,926	9,993
Total liabilities	28,723	28,891
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value: 5,000 shares authorized at September 30, 2022 and December 31, 2021; no shares issued or outstanding at September 30, 2022 or December 31, 2021	0	0
Common stock, $0.001 par value: 160,000 shares authorized at September 30, 2022 and December 31, 2021; 51,694 and 51,265 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively	51	51
Additional paid-in capital	474,089	465,865
Accumulated other comprehensive loss	(1,031)	(238)
Accumulated deficit	(343,751)	(241,873)
Total stockholders’ equity	129,358	223,805
Total liabilities and stockholders’ equity	$ 158,081	$ 252,696

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Condensed Consolidated Balance Sheets (unaudited) (Parenthetical) - $ / shares	Sep. 30, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Preferred stock (in dollars per share)	$ 0.001	$ 0.001
Preferred stock shares authorized (in shares)	5,000,000	5,000,000
Preferred stock shares issued (in shares)	0	0
Preferred stock shares outstanding (in shares)	0	0
Common stock (in dollars per share)	$ 0.001	$ 0.001
Common stock shares authorized (in shares)	160,000,000	160,000,000
Common stock shares issued (in shares)	51,694,000	51,265,000
Common stock shares outstanding (in shares)	51,694,000	51,265,000

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Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) - USD ($) shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenue:
License and collaboration revenue — related party	$ 0	$ 0	$ 0	$ 26,907,000
Operating expenses:
Research and development	23,752,000	23,288,000	80,070,000	65,895,000
General and administrative	7,653,000	6,854,000	22,511,000	21,786,000
Total operating expenses	31,405,000	30,142,000	102,581,000	87,681,000
Operating loss	(31,405,000)	(30,142,000)	(102,581,000)	(60,774,000)
Other income, net	412,000	55,000	721,000	144,000
Loss before provision for income taxes	(30,993,000)	(30,087,000)	(101,860,000)	(60,630,000)
Provision for income taxes	5,000	6,000	18,000	9,000
Net loss	$ (30,998,000)	$ (30,093,000)	$ (101,878,000)	$ (60,639,000)
Net loss per share, basic (in dollars per share)	$ (0.60)	$ (0.59)	$ (1.97)	$ (1.23)
Net loss per share, diluted (in dollars per share)	$ (0.60)	$ (0.59)	$ (1.97)	$ (1.23)
Weighted-average common shares outstanding, basic (in shares)	51,694	51,232	51,670	49,488
Weighted-average common shares outstanding, diluted (in shares)	51,694	51,232	51,670	49,488
Comprehensive loss:
Net loss	$ (30,998,000)	$ (30,093,000)	$ (101,878,000)	$ (60,639,000)
Other comprehensive income (loss):
Unrealized gain (loss) on available-for-sale securities	66,000	5,000	(793,000)	(2,000)
Comprehensive loss	$ (30,932,000)	$ (30,088,000)	$ (102,671,000)	$ (60,641,000)

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Condensed Consolidated Statements of Stockholders' Equity (unaudited) - USD ($) shares in Thousands, $ in Thousands	Total	At The Market Offering	Follow-on Public Offering	Common Stock	Common Stock At The Market Offering	Common Stock Follow-on Public Offering	Additional Paid-In Capital	Additional Paid-In Capital At The Market Offering	Additional Paid-In Capital Follow-on Public Offering	Accumulated Other Comprehensive Loss	Accumulated Deficit
Beginning balance, common stock (in shares) at Dec. 31, 2020				41,729
Beginning balance at Dec. 31, 2020	$ 211,294			$ 42			$ 362,270			$ (17)	$ (151,001)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock from, net of issuance costs (in shares)					3,156	5,750
Issuance of common stock, net of issuance costs		$ 30,221	$ 60,638		$ 3	$ 6		$ 30,218	$ 60,632
Exercises of common stock options (in shares)				342
Exercises of common stock options	1,019						1,019
Vesting of restricted stock units (in shares)				223
Vesting of restricted stock units	0
Stock-based compensation expense	2,825						2,825
Other comprehensive income (loss)	(8)									(8)
Net loss	(26,535)										(26,535)
Ending balance (in shares) at Mar. 31, 2021				51,200
Ending balance at Mar. 31, 2021	279,454			$ 51			456,964			(25)	(177,536)
Beginning balance, common stock (in shares) at Dec. 31, 2020				41,729
Beginning balance at Dec. 31, 2020	211,294			$ 42			362,270			(17)	(151,001)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Other comprehensive income (loss)	(2)
Net loss	(60,639)
Ending balance (in shares) at Sep. 30, 2021				51,240
Ending balance at Sep. 30, 2021	251,367			$ 51			462,975			(19)	(211,640)
Beginning balance, common stock (in shares) at Mar. 31, 2021				51,200
Beginning balance at Mar. 31, 2021	279,454			$ 51			456,964			(25)	(177,536)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercises of common stock options (in shares)				21
Exercises of common stock options	83						83
Stock-based compensation expense	2,935						2,935
Other comprehensive income (loss)	1									1
Net loss	(4,011)										(4,011)
Ending balance (in shares) at Jun. 30, 2021				51,221
Ending balance at Jun. 30, 2021	278,462			$ 51			459,982			(24)	(181,547)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercises of common stock options (in shares)				15
Exercises of common stock options	67						67
Vesting of restricted stock units (in shares)				4
Vesting of restricted stock units	0
Stock-based compensation expense	2,926						2,926
Other comprehensive income (loss)	5									5
Net loss	(30,093)										(30,093)
Ending balance (in shares) at Sep. 30, 2021				51,240
Ending balance at Sep. 30, 2021	$ 251,367			$ 51			462,975			(19)	(211,640)
Beginning balance, common stock (in shares) at Dec. 31, 2021	51,265			51,265
Beginning balance at Dec. 31, 2021	$ 223,805			$ 51			465,865			(238)	(241,873)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercises of common stock options (in shares)				64
Exercises of common stock options	359						359
Vesting of restricted stock units (in shares)				345
Vesting of restricted stock units	0
Stock-based compensation expense	2,829						2,829
Other comprehensive income (loss)	(663)									(663)
Net loss	(37,367)										(37,367)
Ending balance (in shares) at Mar. 31, 2022				51,674
Ending balance at Mar. 31, 2022	$ 188,963			$ 51			469,053			(901)	(279,240)
Beginning balance, common stock (in shares) at Dec. 31, 2021	51,265			51,265
Beginning balance at Dec. 31, 2021	$ 223,805			$ 51			465,865			(238)	(241,873)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercises of common stock options (in shares)	71
Other comprehensive income (loss)	$ (793)
Net loss	$ (101,878)
Ending balance (in shares) at Sep. 30, 2022	51,694			51,694
Ending balance at Sep. 30, 2022	$ 129,358			$ 51			474,089			(1,031)	(343,751)
Beginning balance, common stock (in shares) at Mar. 31, 2022				51,674
Beginning balance at Mar. 31, 2022	188,963			$ 51			469,053			(901)	(279,240)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercises of common stock options (in shares)				7
Exercises of common stock options	33						33
Stock-based compensation expense	2,443						2,443
Other comprehensive income (loss)	(196)									(196)
Net loss	(33,513)										(33,513)
Ending balance (in shares) at Jun. 30, 2022				51,681
Ending balance at Jun. 30, 2022	$ 157,730			$ 51			471,529			(1,097)	(312,753)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercises of common stock options (in shares)	0
Vesting of restricted stock units (in shares)				13
Stock-based compensation expense	$ 2,560						2,560
Other comprehensive income (loss)	66									66
Net loss	$ (30,998)										(30,998)
Ending balance (in shares) at Sep. 30, 2022	51,694			51,694
Ending balance at Sep. 30, 2022	$ 129,358			$ 51			$ 474,089			$ (1,031)	$ (343,751)

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Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities:
Net loss	$ (101,878)	$ (60,639)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	7,832	8,686
Depreciation expense	1,645	2,184
Net amortization of premiums and discounts on investments	748	604
Gain on sale of property and equipment	(93)	0
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	975	(4,732)
Other non-current assets	391	360
Accounts payable	(559)	(290)
Accrued expenses and other current liabilities	3,129	640
Deferred revenue — related party	0	(1,931)
Other liabilities	(301)	(175)
Net cash used in operating activities	(88,111)	(55,293)
Investing activities:
Purchases of investments	(24,928)	(91,914)
Proceeds from maturities of investments	94,875	53,331
Purchases of property and equipment	(696)	(247)
Net cash provided by (used in) investing activities	69,251	(38,830)
Financing activities:
Proceeds from issuance of common stock, net of issuance costs	0	90,826
Proceeds from exercise of stock options	442	1,169
Net cash provided by financing activities	442	91,995
Net decrease in cash, cash equivalents and restricted cash	(18,418)	(2,128)
Cash, cash equivalents and restricted cash, beginning of period	96,799	148,763
Cash, cash equivalents and restricted cash, end of period	78,381	146,635
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accrued expenses	0	77
Supplemental cash flow information:
Cash paid for lease liabilities	3,498	3,760
Cash paid for income taxes	$ 8	$ 8

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Nature of Business

9 Months Ended

Sep. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Nature of Business

Nature of Business

Jounce Therapeutics, Inc. (the “Company”) is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. The Company is subject to a number of risks similar to those of other clinical-stage companies, including dependence on key individuals; the need to develop commercially viable products; competition from other companies, many of which are larger and better capitalized; and the need to obtain adequate additional financing to fund the development of its products.

As of September 30, 2022, the Company had cash, cash equivalents and investments of $130.3 million. The Company expects that its existing cash, cash equivalents and investments will enable it to fund its expected operating expenses and capital expenditure requirements for at least 12 months from November 10, 2022, the filing date of this Quarterly Report on Form 10-Q. The Company expects to finance its future cash needs through a combination of equity or debt financings, collaborations, licensing arrangements and strategic alliances.

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Basis of Presentation and Summary of Significant Accounting Policies

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Basis of Presentation and Summary of Significant Accounting Policies

Basis of Presentation and Summary of Significant Accounting Policies

Basis of Presentation and Consolidation

The accompanying condensed consolidated financial statements as of September 30, 2022 and December 31, 2021, and for the three and nine months ended September 30, 2022 and 2021, have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission (the “SEC”) and generally accepted accounting principles in the United States of America (“GAAP”) as found in the Accounting Standards Codification (“ASC”) of the Financial Accounting Standards Board (“FASB”) for condensed consolidated financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In the opinion of management, these condensed consolidated financial statements reflect all normal recurring adjustments which are necessary for a fair presentation of the Company’s financial position and results of its operations, as of and for the periods presented. These condensed consolidated financial statements should be read in conjunction with the consolidated financial statements and notes thereto contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC on March 2, 2022 (the “Annual Report on Form 10-K”).

The information presented in the condensed consolidated financial statements and related notes as of September 30, 2022, and for the three and nine months ended September 30, 2022 and 2021, is unaudited. The December 31, 2021 condensed consolidated balance sheet included herein was derived from the audited financial statements as of that date, but does not include all disclosures, including notes, required by GAAP for complete financial statements.

Interim results for the nine months ended September 30, 2022 are not necessarily indicative of the results that may be expected for the fiscal year ending December 31, 2022, or any future period.

The accompanying condensed consolidated financial statements include the accounts of Jounce Therapeutics, Inc. and its wholly-owned subsidiary, Jounce Mass Securities, Inc. All intercompany transactions and balances have been eliminated in consolidation.

Summary of Significant Accounting Policies

The significant accounting policies and estimates used in the preparation of the condensed consolidated financial statements are described in the Company’s audited financial statements as of and for the year ended December 31, 2021, and the notes thereto, which are included in the Annual Report on Form 10-K. There have been no material changes in the Company’s significant accounting policies during the nine months ended September 30, 2022.

Use of Estimates

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. On an ongoing basis, the Company’s management evaluates its estimates which include, but are not limited to, accrued expenses, stock-based compensation expense and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions it believes to be reasonable under the circumstances. Actual results could differ from those estimates.

Recent Accounting Pronouncements, Not Yet AdoptedIn June 2016, the FASB issued Accounting Standards Update (“ASU”) 2016-13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments. This standard requires that credit losses be reported using an expected losses model rather than the incurred losses model that is currently used, and it establishes additional disclosure requirements related to credit risks. For available-for-sale debt securities with expected credit losses, this standard now requires allowances to be recorded instead of reducing the amortized cost of the investment. This ASU is effective for smaller reporting companies for fiscal years beginning after December 15, 2022, with early adoption permitted. Accordingly, the Company will now adopt this standard effective January 1, 2023. The adoption of ASU 2016-13 is not expected to have a material impact on the Company’s financial position or results of operations upon adoption.

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License and Collaboration Revenue

9 Months Ended

Sep. 30, 2022

Revenue from Contract with Customer [Abstract]

License and Collaboration Revenue

License and Collaboration Revenue

Gilead License Agreement

On August 31, 2020, the Company and Gilead Sciences, Inc. (“Gilead”) entered into an exclusive license agreement (the “Gilead License Agreement”) to license the Company’s GS-1811, formerly JTX-1811, program to Gilead, which became effective on October 16, 2020. Concurrently with the Gilead License Agreement, the Company and Gilead entered into a stock purchase agreement (the “Stock Purchase Agreement”) and a registration rights agreement (the “Registration Rights Agreement”, and together with the Gilead License Agreement and the Stock Purchase Agreement, the “Transaction Agreements”). Pursuant to the Gilead License Agreement, the Company granted to Gilead a worldwide and exclusive license to develop, manufacture and commercialize GS-1811 and certain derivatives thereof (the “Licensed Products”). Gilead paid the Company a one-time, non-refundable upfront payment of $85.0 million in October 2020. The Company continued to develop GS-1811 during the initial development term, which included conducting activities defined within the agreement to advance GS-1811 through the clearance of an investigational new drug application (“IND”), which occurred in June 2021, after which the program transitioned to Gilead.

Milestone and Royalties

The Company is entitled to receive payments from Gilead upon the achievement of specified clinical, regulatory and sales milestones, including potential clinical development and regulatory milestone payments up to an aggregate total of $510.0 million and potential sales milestone payments up to an aggregate total of $175.0 million.

The Company is also eligible to receive tiered royalty payments based on a percentage of annual worldwide net sales ranging from the high-single digits to mid-teens, based on future annual net sales of the Licensed Products, on a Licensed Product-by-Licensed Product and country-by-country basis.

In June 2021, the Company received clearance of the IND for GS-1811 from the U.S. Food and Drug Administration (“FDA”) and achieved a $25.0 million clinical development and regulatory milestone under the Gilead License Agreement.

Termination

Gilead may terminate the Gilead License Agreement for convenience, in its sole discretion, in its entirety or on a Licensed Product-by-Licensed Product or region-by-region basis, at any time with prior written notice to the Company. Unless terminated earlier in accordance with its terms, the Gilead License Agreement provides that it will expire (i) on a Licensed Product-by-Licensed Product (as defined in the Gilead License Agreement) and country-by-country basis on the date of the expiration of the royalty term with respect to such Licensed Product in such country and (ii) in its entirety upon the expiration of all applicable royalty terms with respect to the Licensed Products in all countries, following which the applicable licenses under the Gilead License Agreement will become fully paid-up, perpetual, irrevocable and royalty-free.

Accounting Analysis

Identification of the Contract(s)

The Company assessed the Gilead License Agreement and concluded that it represents a contract with a customer within the scope of ASC 606, Revenue from Contracts with Customers (“ASC 606”). In addition, the Company determined that the Gilead License Agreement and Stock Purchase Agreement should be evaluated as a combined contract in accordance with ASC 606 given that the agreements were executed contemporaneously, negotiated as a package and have the same commercial objective to provide funding to further the Company’s research and development activities.

Identification of Promises and Performance Obligations

The Company assessed the promises under the Gilead License Agreement and concluded that the (i) delivery of a worldwide and exclusive license to develop, manufacture and commercialize GS-1811 (the “GS-1811 License”) and (ii) provision of certain research transition activities, specifically outlined within the Gilead License Agreement, related to the advancement of GS-1811 through the clearance of an IND application and transition of the GS-1811 program to Gilead (the “Research and Transition Services”) are capable of being distinct and distinct within the context of the Gilead License Agreement. Based upon this evaluation, the Company concluded that its promise to deliver the GS-1811 License and promise to perform Research and Transition Services represent separate performance obligations in the Gilead License Agreement.

Determination of Transaction Price

The Company received a non-refundable upfront payment of $85.0 million upon the closing of the Gilead License Agreement. This upfront payment represents an element of fixed consideration under the Gilead License Agreement.

The Company also evaluated as possible variable consideration the milestones and royalties discussed above. With respect to clinical development and regulatory milestones, based upon the high degree of uncertainty and risk associated with these potential payments, the Company concluded that all such amounts should be fully constrained and are not included in the initial transaction price. As part of the evaluation of the constraint the Company considered certain factors, including that receipt of such milestones is outside the control of the Company and the probability of success criteria is estimated. Each of these variable consideration items was evaluated under the most-likely amount method. As for royalties and sales milestones, the Company determined that the royalties and milestones relate solely to the GS-1811 License, which is a license of intellectual property (“IP”). Accordingly, the Company did not include any potential royalty or sales milestone amounts in the initial transaction price, and the Company will not recognize revenue related to these royalties and sales milestones until the associated sales occur and relevant thresholds are met. The Company will re-evaluate the transaction price in each reporting period as uncertain events are resolved or as other changes in circumstances occur, and if necessary, will adjust its estimate of the transaction price to include milestones as they become probable of occurrence.

Allocation of Transaction Price to Performance Obligations

The Company allocated the transaction price to each performance obligation on a relative estimated standalone selling price basis. The Company developed the estimated standalone selling price for the GS-1811 License based on the present value of expected future cash flows associated with the license and related clinical development and regulatory milestones. In developing such estimate, the Company applied judgement in determining the timing needed to develop the Licensed Product, the probability of success, and the discount rate. The Company developed the estimated standalone selling price for the Research and Transition Services obligation based on the nature of the services to be performed and the Company’s best estimate of the length of time required to perform the services necessary to achieve clearance of an IND application for the GS-1811 program.

Based on the above considerations, $3.5 million of the initial transaction price was allocated to the Research and Transition Services performance obligation.

Recognition of Revenue

The Company determined that the GS-1811 License is a functional license as the underlying IP has significant standalone functionality. In addition, the Company determined that October 16, 2020 represents (i) the date at which the Company made available the IP to Gilead and (ii) the beginning of the period during which Gilead is able to use and benefit from its right to use the IP. Based upon these considerations, the Company recognized the entirety of the initial transaction price allocated to the GS-1811 License performance obligation during the year ended December 31, 2020.

Further, the Company determined the input method under ASC 606 is the most appropriate method of revenue recognition for the Research and Transition Services performance obligation. The method of measuring progress towards delivery of the services incorporated actual internal and external costs incurred, relative to total internal and external costs expected to be incurred to satisfy the performance obligation. The period over which total costs were estimated reflected the Company’s best

estimate of the period over which it would perform the Research and Transition Services to achieve clearance of an IND application of the GS-1811 program and transition the program to Gilead.No revenue was recognized under the contract during the three and nine months ended September 30, 2022 as all remaining performance obligations were satisfied during the year ended December 31, 2021. During the nine months ended September 30, 2021, the Company recognized $26.9 million of license and collaboration revenue related to achievement of a $25.0 million clinical development and regulatory milestone for FDA clearance of the IND for GS-1811 and $1.9 million related to the completion of Research and Transition Services. No revenue was recognized during the three months ended September 30, 2021.

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Fair Value Measurements

9 Months Ended

Sep. 30, 2022

Fair Value Disclosures [Abstract]

Fair Value Measurements

Fair Value Measurements

Fair value is an exit price, representing the amount that would be received from the sale of an asset or paid to transfer a liability in an orderly transaction between market participants. Fair value is determined based on observable and unobservable inputs. Observable inputs reflect readily obtainable data from independent sources, while unobservable inputs reflect certain market assumptions. As a basis for considering such assumptions, GAAP establishes a three-tier value hierarchy, which prioritizes the inputs used to develop the assumptions and for measuring fair value as follows: (Level 1) observable inputs such as quoted prices in active markets for identical assets; (Level 2) inputs other than the quoted prices in active markets that are observable either directly or indirectly; and (Level 3) unobservable inputs in which there is little or no market data, which requires the Company to develop its own assumptions. This hierarchy requires the Company to use observable market data, when available, and to minimize the use of unobservable inputs when determining fair value.

The Company measures the fair value of money market funds, U.S. Treasuries and government agency securities based on quoted prices in active markets for identical securities. Investments also include corporate debt securities which are valued either based on recent trades of securities in inactive markets or based on quoted market prices of similar instruments and other significant inputs derived from or corroborated by observable market data.

The carrying amounts reflected in the condensed consolidated balance sheets for cash, prepaid expenses and other current assets, accounts payable and accrued expenses approximate their fair values, due to their short-term nature.

Assets measured at fair value on a recurring basis as of September 30, 2022 were as follows (in thousands):

	Total		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Money market funds, included in cash equivalents	$	77,111	$	77,111	$	—	$	—
Investments:
Corporate debt securities	21,419		—		21,419		—
U.S. Treasuries	24,066		24,066		—		—
Government agency securities	7,736		—		7,736		—
Totals	$	130,332	$	101,177	$	29,155	$	—

Assets measured at fair value on a recurring basis as of December 31, 2021 were as follows (in thousands):

	Total		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Money market funds, included in cash equivalents	$	95,529	$	95,529	$	—	$	—
Investments:
Corporate debt securities	86,470		—		86,470		—
U.S. Treasuries	30,271		30,271		—		—
Government agency securities	7,953		—		7,953		—
Totals	$	220,223	$	125,800	$	94,423	$	—

There were no changes in valuation techniques during the nine months ended September 30, 2022 or during the year ended December 31, 2021. There were no liabilities measured at fair value on a recurring basis as of September 30, 2022 or December 31, 2021.

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Investments

9 Months Ended

Sep. 30, 2022

Investments, Debt and Equity Securities [Abstract]

Investments

Investments

Short-term investments consist of investments with maturities greater than ninety days and less than one year from the balance sheet date. Long-term investments consist of investments with maturities of greater than one year that are not expected to be used to fund current operations. The Company classifies all of its investments as available-for-sale securities. Accordingly, these investments are recorded at fair value. Realized gains and losses, amortization and accretion of discounts and premiums are included in other income, net. Unrealized gains and losses on available-for-sale securities are included in other comprehensive income as a component of stockholders’ equity until realized.

Cash equivalents, short-term investments and long-term investments as of September 30, 2022 were comprised as follows (in thousands):

	September 30, 2022
	Amortized Cost		Unrealized Gains		Unrealized Losses		Fair Value
Cash equivalents and short-term investments:
Money market funds, included in cash equivalents	$	77,111	$	—	$	—	$	77,111
Corporate debt securities	21,741		—		(322)		21,419
U.S. Treasuries	24,559		—		(493)		24,066
Government agency securities	6,158		—		(145)		6,013
Total cash equivalents and short-term investments	129,569		—		(960)		128,609
Long-term investments:
Government agency securities	1,794		—		(71)		1,723
Total long-term investments	1,794		—		(71)		1,723
Total cash equivalents and investments	$	131,363	$	—	$	(1,031)	$	130,332

Cash equivalents, short-term investments and long-term investments as of December 31, 2021 were comprised as follows (in thousands):

	December 31, 2021
	Amortized Cost		Unrealized Gains		Unrealized Losses		Fair Value
Cash equivalents and short-term investments:
Money market funds, included in cash equivalents	$	95,529	$	—	$	—	$	95,529
Corporate debt securities	69,316		—		(34)		69,282
U.S. Treasuries	13,777		—		(22)		13,755
Total cash equivalents and short-term investments	178,622		—		(56)		178,566
Long-term investments:
Corporate debt securities	17,276		—		(88)		17,188
U.S. Treasuries	16,580		—		(64)		16,516
Government agency securities	7,983		—		(30)		7,953
Total long-term investments	41,839		—		(182)		41,657
Total cash equivalents and investments	$	220,461	$	—	$	(238)	$	220,223

As of September 30, 2022 and December 31, 2021, the aggregate fair value of securities that were in an unrealized loss position for less than twelve months was $39.2 million and $86.7 million, respectively. As of September 30, 2022 and December 31, 2021, the aggregate fair value of securities that were in an unrealized loss position for more than twelve months was $14.0 million and $4.8 million, respectively. As of September 30, 2022, the Company did not intend to sell, and would not be more likely than not required to sell, the securities in an unrealized loss position before recovery of their amortized cost bases. Furthermore, the Company determined that there was no material change in the credit risk of these securities. As a result, the Company determined it did not hold any securities with any other-than-temporary impairment as of September 30, 2022.

There were no realized gains or losses on available-for-sale securities during the three or nine months ended September 30, 2022 or September 30, 2021.

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Restricted Cash

9 Months Ended

Sep. 30, 2022

Cash and Cash Equivalents [Abstract]

Restricted Cash

Restricted Cash

As of both September 30, 2022 and December 31, 2021, the Company maintained non-current restricted cash of $1.3 million. This amount is included within “Other non-current assets” in the accompanying condensed consolidated balance sheets and is comprised solely of a security deposit required pursuant to the lease for the Company’s corporate headquarters.

The following table provides a reconciliation of cash, cash equivalents and restricted cash that sums to the total of the same such amounts shown in the condensed consolidated statements of cash flows (in thousands):

	Nine Months Ended September 30, 2022				Nine Months Ended September 30, 2021
	Beginning of Period		End of Period		Beginning of Period		End of Period
Cash and cash equivalents	$	95,529	$	77,111	$	147,493	$	145,365
Restricted cash	1,270		1,270		1,270		1,270
Cash, cash equivalents and restricted cash	$	96,799	$	78,381	$	148,763	$	146,635

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Accrued Expenses

9 Months Ended

Sep. 30, 2022

Payables and Accruals [Abstract]

Accrued Expenses

Accrued Expenses

Accrued expenses as of September 30, 2022 and December 31, 2021 were comprised as follows (in thousands):

	September 30,		December 31,
	2022		2021
External research, development and professional services	$	9,749	$	6,252
Employee compensation and benefits	6,435		6,844
Lab consumables and other	420		371
Total accrued expenses	$	16,604	$	13,467

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Common Stock and Preferred Stock

9 Months Ended

Sep. 30, 2022

Equity [Abstract]

Common Stock and Preferred Stock

Common Stock and Preferred Stock

Common Stock

The Company is authorized to issue 160,000,000 shares of common stock. Holders of common stock are entitled to one vote per share. Holders of common stock are entitled to receive dividends, if and when declared by the board of directors.

On December 17, 2019, the Company entered into a Sales Agreement (the “2019 Sales Agreement”) with Cowen and Company, LLC (“Cowen”) pursuant to which the Company could offer and sell shares of its common stock with an aggregate offering price of up to $50.0 million under an “at the market” (“ATM”) offering program (the “2019 ATM Offering”). The 2019 Sales Agreement provided that Cowen would be entitled to a sales commission equal to 3.0% of the gross sales price per share of all shares sold under the 2019 ATM Offering. During the first quarter of 2021, the Company sold an aggregate of 3,156,200 shares at an average price of $9.87 per share for net proceeds of $30.2 million, which completed the sale of all available amounts under the 2019 ATM Offering.

In addition, during the first quarter of 2021, the Company completed a follow-on public offering of its common stock, selling an aggregate of 5,750,000 shares of common stock at a public offering price of $11.25 per share for net proceeds of $60.6 million, after deducting underwriting discounts and commissions and offering fees.

On November 4, 2021, the Company entered into a new Sales Agreement with Cowen (the “2021 Sales Agreement”), pursuant to which the Company may offer and sell shares of its common stock with an aggregate offering price of up to $75.0 million under an ATM offering program (the “2021 ATM Offering”). The 2021 Sales Agreement provides that Cowen will be entitled to a sales commission equal to 3.0% of the gross sales price per share of all shares sold under the 2021 ATM Offering. No sales have been made under the 2021 ATM Offering.

Preferred Stock

The Company is authorized to issue 5,000,000 shares of undesignated preferred stock in one or more series. As of September 30, 2022 and December 31, 2021, no shares of preferred stock were issued or outstanding.

Shares Reserved for Future Issuance

As of September 30, 2022 and December 31, 2021, the Company had reserved for future issuance the following number of shares of common stock (in thousands):

	September 30,	December 31,
	2022	2021
Shares reserved for vesting of restricted stock units	1,016	833
Shares reserved for exercises of outstanding stock options	8,592	7,629
Shares reserved for future issuance under the 2017 Stock Option and Incentive Plan	1,734	1,258
Total shares reserved for future issuance	11,342	9,720

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Stock-based Compensation

9 Months Ended

Sep. 30, 2022

Share-Based Payment Arrangement [Abstract]

Stock-based Compensation

Stock-based Compensation

2013 Stock Option and Grant Plan

In February 2013, the board of directors adopted and the Company’s stockholders approved the 2013 Stock Option and Grant Plan (the “2013 Plan”), as amended and restated, under which it could grant incentive stock options (“ISOs”), non-qualified stock options, restricted stock awards (“RSAs”) and restricted stock units (“RSUs”) to eligible employees, officers, directors, and consultants. The 2013 Plan was subsequently amended in January 2015, April 2015, July 2015, March 2016 and October 2016 to allow for the issuance of additional shares of common stock.

2017 Stock Option and Incentive Plan

In January 2017, the board of directors adopted and the Company’s stockholders approved the 2017 Stock Option and Incentive Plan (the “2017 Plan”). Upon the adoption of the 2017 Plan, no further awards will be granted under the 2013 Plan.

The 2017 Plan provides for the grant of ISOs, non-qualified stock options, RSAs, RSUs, stock appreciation rights and other stock-based awards. The Company’s employees, officers, directors and consultants and advisors are eligible to receive awards under the 2017 Plan. The terms of awards, including vesting requirements, are determined by the board of directors, subject to the provisions of the 2017 Plan.

The Company initially registered on Form S-8 1,753,758 shares of common stock under the 2017 Plan, which was comprised of (i) 1,510,000 shares of common stock reserved for issuance under the 2017 Plan, plus (ii) 243,758 shares of common stock originally reserved for issuance under the 2013 Plan that became available for issuance under the 2017 Plan upon the completion of the Company’s IPO. The 2017 Plan also provides that an additional number of shares will automatically be added to the shares authorized for issuance under the 2017 Plan on January 1, 2018 and each January 1st thereafter. The number of shares added each year will be equal to the lesser of (i) 4% of the outstanding shares on the immediately preceding December 31st or (ii) such amount as determined by the compensation committee of the board of directors. Effective January 1, 2021 and 2022, 1,669,162 and 2,050,601 additional shares, respectively, were automatically added to the shares authorized for issuance under the 2017 Plan.

As of September 30, 2022, there were 1,733,603 shares available for future issuance under the 2017 Plan.

Inducement Stock Options

The Company may grant, upon approval by the compensation committee of the board of directors, awards, including options to purchase shares of common stock, as an inducement to employment in accordance with Nasdaq Listing Rule 5635(c)(4). The securities are issued pursuant to Section 4(a)(2) under the Securities Act of 1933, as amended, relating to transactions by an issuer not involving any public offering. These options are subject to substantially the same terms as options issued pursuant to the 2017 Plan. During the second quarter of 2021, the Company granted an option to purchase 225,000 shares of common stock as an inducement award.

2017 Employee Stock Purchase Plan

In January 2017, the board of directors adopted and the Company’s stockholders approved the 2017 Employee Stock Purchase Plan (the “2017 ESPP”). The Company initially reserved 302,000 shares of common stock for future issuance under the 2017 ESPP. The 2017 ESPP also provides that an additional number of shares will automatically be added to the shares authorized for issuance under the 2017 ESPP on January 1, 2018 and each January 1st thereafter through January 1, 2027. The number of shares added each year will be equal to the lesser of (i) 1% of the outstanding shares on the immediately preceding December 31st, (ii) 603,000 shares or (iii) such amount as determined by the compensation committee of the board of directors. Effective January 1, 2021 and 2022, 417,291 and 512,650 additional shares, respectively, were automatically added to the shares authorized for issuance under the 2017 ESPP. No offering periods under the 2017 ESPP had been initiated as of September 30, 2022.

Stock-based Compensation Expense

Total stock-based compensation expense recognized in the condensed consolidated statements of operations and comprehensive loss for the three and nine months ended September 30, 2022 and 2021 was as follows (in thousands):

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Research and development	$	1,254	$	1,628	$	3,913	$	4,129
General and administrative	1,306		1,298		3,919		4,557
Total stock-based compensation expense	$	2,560	$	2,926	$	7,832	$	8,686

RSU Activity

The Company has also granted RSUs to its employees under the 2017 Plan. The following table summarizes RSU activity for the nine months ended September 30, 2022 (in thousands, except per share amounts):

	RSUs	Weighted-Average Grant Date Fair Value per Share
Unvested as of December 31, 2021	833	$	9.13
Issued	670	$	7.25
Vested	(358)	$	8.15
Cancelled	(129)	$	8.59
Unvested as of September 30, 2022	1,016	$	8.31

The aggregate fair value of RSUs that vested during the three and nine months ended September 30, 2022, based upon the fair values of the stock underlying the RSUs on the day of vesting, was less than $0.1 million and $2.7 million, respectively. The aggregate fair value of RSUs that vested during the three and nine months ended September 30, 2021, based upon the fair values of the stock underlying the RSUs on the day of vesting, was less than $0.1 million and $1.5 million, respectively.

As of September 30, 2022, there was unrecognized stock-based compensation expense related to unvested RSUs of $5.5 million, which the Company expects to recognize over a weighted-average period of approximately 1.7 years.

Stock Option Activity

The fair value of stock options granted during the three and nine months ended September 30, 2022 and 2021 was calculated on the date of grant using the following weighted-average assumptions:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Risk-free interest rate	2.9	%	1.0	%	2.0	%	0.8	%
Expected dividend yield	—	%	—	%	—	%	—	%
Expected term (in years)	6.1		6.1		6.0		6.0
Expected volatility	80.7	%	82.0	%	80.9	%	81.9	%

Using the Black-Scholes option pricing model, the weighted-average grant date fair value of stock options granted during the three months ended September 30, 2022 and 2021 was $2.20 per share and $4.24 per share, respectively. The weighted-average grant date fair value of stock options granted during the nine months ended September 30, 2022 and 2021 was $4.57 per share and $7.22 per share, respectively.

The following table summarizes stock option activity during the nine months ended September 30, 2022 (in thousands, except per share amounts):

	Options	Weighted-Average Exercise Price		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value
Outstanding at December 31, 2021	7,629	$	8.87	6.4	$	16,881
Granted	1,747	$	6.57
Exercised	(71)	$	5.49
Cancelled	(713)	$	9.29
Outstanding at September 30, 2022	8,592	$	8.39	6.4	$	1,255
Exercisable at September 30, 2022	5,751	$	8.77	5.1	$	1,255

No stock options were exercised during the three months ended September 30, 2022. The aggregate intrinsic value of stock options exercised during the three months ended September 30, 2021 was less than $0.1 million. The aggregate intrinsic value of stock options exercised during the nine months ended September 30, 2022 and 2021 was $0.1 million and $2.9 million, respectively.

As of September 30, 2022, there was unrecognized stock-based compensation expense related to unvested stock options of $13.5 million, which the Company expects to recognize over a weighted-average period of approximately 2.5 years.

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Related-party Transactions	9 Months Ended
	Sep. 30, 2022
Related Party Transactions [Abstract]
Related-party Transactions	Related-party TransactionsIn August 2020, the Company entered into the Gilead License Agreement and Stock Purchase Agreement under which it received a non-refundable upfront payment of $85.0 million and cash consideration of $35.0 million for Gilead’s purchase of 5,539,727 shares of the Company’s common stock. As of September 30, 2022, the Company had no reimbursable expenses due from Gilead.

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Net Loss per Share

9 Months Ended

Sep. 30, 2022

Earnings Per Share [Abstract]

Net Loss per Share

Net Loss per Share

For purposes of the diluted net loss per share calculation, outstanding stock options and unvested RSUs are considered to be potentially dilutive securities, however the following weighted-average amounts were excluded from the calculation of diluted net loss per share because their effect would be anti-dilutive (in thousands):

	Three Months Ended September 30,		Nine Months Ended September 30,
	2022	2021	2022	2021
Outstanding stock options	8,646	7,559	8,567	7,284
Unvested RSUs	999	822	981	771
Total	9,645	8,381	9,548	8,055

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Subsequent Events	9 Months Ended
	Sep. 30, 2022
Subsequent Events [Abstract]
Subsequent Events	Subsequent EventsIn October 2022, the Company earned a $15.0 million clinical development and regulatory milestone associated with GS-1811 under the Gilead License Agreement. The Company expects to receive the milestone payment in the fourth quarter of 2022.

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Basis of Presentation and Summary of Significant Accounting Policies (Policies)

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Basis of Presentation

The accompanying condensed consolidated financial statements as of September 30, 2022 and December 31, 2021, and for the three and nine months ended September 30, 2022 and 2021, have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission (the “SEC”) and generally accepted accounting principles in the United States of America (“GAAP”) as found in the Accounting Standards Codification (“ASC”) of the Financial Accounting Standards Board (“FASB”) for condensed consolidated financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In the opinion of management, these condensed consolidated financial statements reflect all normal recurring adjustments which are necessary for a fair presentation of the Company’s financial position and results of its operations, as of and for the periods presented. These condensed consolidated financial statements should be read in conjunction with the consolidated financial statements and notes thereto contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC on March 2, 2022 (the “Annual Report on Form 10-K”).

The information presented in the condensed consolidated financial statements and related notes as of September 30, 2022, and for the three and nine months ended September 30, 2022 and 2021, is unaudited. The December 31, 2021 condensed consolidated balance sheet included herein was derived from the audited financial statements as of that date, but does not include all disclosures, including notes, required by GAAP for complete financial statements.

Interim results for the nine months ended September 30, 2022 are not necessarily indicative of the results that may be expected for the fiscal year ending December 31, 2022, or any future period.

Principles of Consolidation

The accompanying condensed consolidated financial statements include the accounts of Jounce Therapeutics, Inc. and its wholly-owned subsidiary, Jounce Mass Securities, Inc. All intercompany transactions and balances have been eliminated in consolidation.

Use of Estimates

Use of Estimates

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. On an ongoing basis, the Company’s management evaluates its estimates which include, but are not limited to, accrued expenses, stock-based compensation expense and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions it believes to be reasonable under the circumstances. Actual results could differ from those estimates.

Recent Accounting Pronouncements, Not Yet Adopted

Recent Accounting Pronouncements, Not Yet AdoptedIn June 2016, the FASB issued Accounting Standards Update (“ASU”) 2016-13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments. This standard requires that credit losses be reported using an expected losses model rather than the incurred losses model that is currently used, and it establishes additional disclosure requirements related to credit risks. For available-for-sale debt securities with expected credit losses, this standard now requires allowances to be recorded instead of reducing the amortized cost of the investment. This ASU is effective for smaller reporting companies for fiscal years beginning after December 15, 2022, with early adoption permitted. Accordingly, the Company will now adopt this standard effective January 1, 2023. The adoption of ASU 2016-13 is not expected to have a material impact on the Company’s financial position or results of operations upon adoption.

Fair Value Measurement Policy

Fair value is an exit price, representing the amount that would be received from the sale of an asset or paid to transfer a liability in an orderly transaction between market participants. Fair value is determined based on observable and unobservable inputs. Observable inputs reflect readily obtainable data from independent sources, while unobservable inputs reflect certain market assumptions. As a basis for considering such assumptions, GAAP establishes a three-tier value hierarchy, which prioritizes the inputs used to develop the assumptions and for measuring fair value as follows: (Level 1) observable inputs such as quoted prices in active markets for identical assets; (Level 2) inputs other than the quoted prices in active markets that are observable either directly or indirectly; and (Level 3) unobservable inputs in which there is little or no market data, which requires the Company to develop its own assumptions. This hierarchy requires the Company to use observable market data, when available, and to minimize the use of unobservable inputs when determining fair value.

The Company measures the fair value of money market funds, U.S. Treasuries and government agency securities based on quoted prices in active markets for identical securities. Investments also include corporate debt securities which are valued either based on recent trades of securities in inactive markets or based on quoted market prices of similar instruments and other significant inputs derived from or corroborated by observable market data.

The carrying amounts reflected in the condensed consolidated balance sheets for cash, prepaid expenses and other current assets, accounts payable and accrued expenses approximate their fair values, due to their short-term nature.

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Fair Value Measurements (Tables)

9 Months Ended

Sep. 30, 2022

Fair Value Disclosures [Abstract]

Assets Measured at Fair Value

Assets measured at fair value on a recurring basis as of September 30, 2022 were as follows (in thousands):

	Total		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Money market funds, included in cash equivalents	$	77,111	$	77,111	$	—	$	—
Investments:
Corporate debt securities	21,419		—		21,419		—
U.S. Treasuries	24,066		24,066		—		—
Government agency securities	7,736		—		7,736		—
Totals	$	130,332	$	101,177	$	29,155	$	—

Assets measured at fair value on a recurring basis as of December 31, 2021 were as follows (in thousands):

	Total		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Money market funds, included in cash equivalents	$	95,529	$	95,529	$	—	$	—
Investments:
Corporate debt securities	86,470		—		86,470		—
U.S. Treasuries	30,271		30,271		—		—
Government agency securities	7,953		—		7,953		—
Totals	$	220,223	$	125,800	$	94,423	$	—

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Investments (Tables)

9 Months Ended

Sep. 30, 2022

Investments, Debt and Equity Securities [Abstract]

Schedule of Available-for-sale Securities by Security Type

Cash equivalents, short-term investments and long-term investments as of September 30, 2022 were comprised as follows (in thousands):

	September 30, 2022
	Amortized Cost		Unrealized Gains		Unrealized Losses		Fair Value
Cash equivalents and short-term investments:
Money market funds, included in cash equivalents	$	77,111	$	—	$	—	$	77,111
Corporate debt securities	21,741		—		(322)		21,419
U.S. Treasuries	24,559		—		(493)		24,066
Government agency securities	6,158		—		(145)		6,013
Total cash equivalents and short-term investments	129,569		—		(960)		128,609
Long-term investments:
Government agency securities	1,794		—		(71)		1,723
Total long-term investments	1,794		—		(71)		1,723
Total cash equivalents and investments	$	131,363	$	—	$	(1,031)	$	130,332

Cash equivalents, short-term investments and long-term investments as of December 31, 2021 were comprised as follows (in thousands):

	December 31, 2021
	Amortized Cost		Unrealized Gains		Unrealized Losses		Fair Value
Cash equivalents and short-term investments:
Money market funds, included in cash equivalents	$	95,529	$	—	$	—	$	95,529
Corporate debt securities	69,316		—		(34)		69,282
U.S. Treasuries	13,777		—		(22)		13,755
Total cash equivalents and short-term investments	178,622		—		(56)		178,566
Long-term investments:
Corporate debt securities	17,276		—		(88)		17,188
U.S. Treasuries	16,580		—		(64)		16,516
Government agency securities	7,983		—		(30)		7,953
Total long-term investments	41,839		—		(182)		41,657
Total cash equivalents and investments	$	220,461	$	—	$	(238)	$	220,223

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Restricted Cash (Tables)

9 Months Ended

Sep. 30, 2022

Cash and Cash Equivalents [Abstract]

Schedule of Restricted Cash

The following table provides a reconciliation of cash, cash equivalents and restricted cash that sums to the total of the same such amounts shown in the condensed consolidated statements of cash flows (in thousands):

	Nine Months Ended September 30, 2022				Nine Months Ended September 30, 2021
	Beginning of Period		End of Period		Beginning of Period		End of Period
Cash and cash equivalents	$	95,529	$	77,111	$	147,493	$	145,365
Restricted cash	1,270		1,270		1,270		1,270
Cash, cash equivalents and restricted cash	$	96,799	$	78,381	$	148,763	$	146,635

Schedule of Cash and Cash Equivalents

The following table provides a reconciliation of cash, cash equivalents and restricted cash that sums to the total of the same such amounts shown in the condensed consolidated statements of cash flows (in thousands):

	Nine Months Ended September 30, 2022				Nine Months Ended September 30, 2021
	Beginning of Period		End of Period		Beginning of Period		End of Period
Cash and cash equivalents	$	95,529	$	77,111	$	147,493	$	145,365
Restricted cash	1,270		1,270		1,270		1,270
Cash, cash equivalents and restricted cash	$	96,799	$	78,381	$	148,763	$	146,635

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Accrued Expenses (Tables)

9 Months Ended

Sep. 30, 2022

Payables and Accruals [Abstract]

Schedule of Accrued Expenses

Accrued expenses as of September 30, 2022 and December 31, 2021 were comprised as follows (in thousands):

	September 30,		December 31,
	2022		2021
External research, development and professional services	$	9,749	$	6,252
Employee compensation and benefits	6,435		6,844
Lab consumables and other	420		371
Total accrued expenses	$	16,604	$	13,467

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Common Stock and Preferred Stock (Tables)

9 Months Ended

Sep. 30, 2022

Equity [Abstract]

Schedule of Stock by Class

As of September 30, 2022 and December 31, 2021, the Company had reserved for future issuance the following number of shares of common stock (in thousands):

	September 30,	December 31,
	2022	2021
Shares reserved for vesting of restricted stock units	1,016	833
Shares reserved for exercises of outstanding stock options	8,592	7,629
Shares reserved for future issuance under the 2017 Stock Option and Incentive Plan	1,734	1,258
Total shares reserved for future issuance	11,342	9,720

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Stock-based Compensation (Tables)

9 Months Ended

Sep. 30, 2022

Share-Based Payment Arrangement [Abstract]

Schedule of Stock-Based Compensation Expense

Total stock-based compensation expense recognized in the condensed consolidated statements of operations and comprehensive loss for the three and nine months ended September 30, 2022 and 2021 was as follows (in thousands):

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Research and development	$	1,254	$	1,628	$	3,913	$	4,129
General and administrative	1,306		1,298		3,919		4,557
Total stock-based compensation expense	$	2,560	$	2,926	$	7,832	$	8,686

Schedule of Restricted Stock Activity

The Company has also granted RSUs to its employees under the 2017 Plan. The following table summarizes RSU activity for the nine months ended September 30, 2022 (in thousands, except per share amounts):

	RSUs	Weighted-Average Grant Date Fair Value per Share
Unvested as of December 31, 2021	833	$	9.13
Issued	670	$	7.25
Vested	(358)	$	8.15
Cancelled	(129)	$	8.59
Unvested as of September 30, 2022	1,016	$	8.31

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions

The fair value of stock options granted during the three and nine months ended September 30, 2022 and 2021 was calculated on the date of grant using the following weighted-average assumptions:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Risk-free interest rate	2.9	%	1.0	%	2.0	%	0.8	%
Expected dividend yield	—	%	—	%	—	%	—	%
Expected term (in years)	6.1		6.1		6.0		6.0
Expected volatility	80.7	%	82.0	%	80.9	%	81.9	%

Schedule of Stock Options, Activity

The following table summarizes stock option activity during the nine months ended September 30, 2022 (in thousands, except per share amounts):

	Options	Weighted-Average Exercise Price		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value
Outstanding at December 31, 2021	7,629	$	8.87	6.4	$	16,881
Granted	1,747	$	6.57
Exercised	(71)	$	5.49
Cancelled	(713)	$	9.29
Outstanding at September 30, 2022	8,592	$	8.39	6.4	$	1,255
Exercisable at September 30, 2022	5,751	$	8.77	5.1	$	1,255

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Net Loss per Share (Tables)

9 Months Ended

Sep. 30, 2022

Earnings Per Share [Abstract]

Schedule of Antidilutive Securities Excluded from Computation of Net Loss per Share

For purposes of the diluted net loss per share calculation, outstanding stock options and unvested RSUs are considered to be potentially dilutive securities, however the following weighted-average amounts were excluded from the calculation of diluted net loss per share because their effect would be anti-dilutive (in thousands):

	Three Months Ended September 30,		Nine Months Ended September 30,
	2022	2021	2022	2021
Outstanding stock options	8,646	7,559	8,567	7,284
Unvested RSUs	999	822	981	771
Total	9,645	8,381	9,548	8,055

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Nature of Business (Details) - USD ($) $ in Millions	Nov. 10, 2022	Sep. 30, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cash, cash equivalents, and marketable securities		$ 130.3
Scenario, Forecast
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Duration of funding requirement	12 months

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License and Collaboration Revenue - Narrative (Details) - USD ($)		1 Months Ended			3 Months Ended		9 Months Ended
	Aug. 31, 2020	Jun. 30, 2021	Oct. 31, 2020	Aug. 31, 2020	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Oct. 16, 2020
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone revenue					$ 0	$ 0	$ 0	$ 26,907,000
Gilead Transaction Agreements
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Non-refundable upfront payment received			$ 85,000,000
Aggregate revenue for clinical and regulatory milestones	$ 510,000,000
Aggregate revenue for sales milestones	$ 175,000,000
Gilead Transaction Agreements | Gilead Sciences, Inc. | Gilead Transaction Agreements
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Non-refundable upfront payment received			$ 85,000,000	$ 85,000,000
Gilead Transaction Agreements | GS-1811 License
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone achievement earned		$ 25,000,000
Milestone revenue								25,000,000
Gilead Transaction Agreements | Research and Transition Services
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Transaction price									$ 3,500,000
Milestone revenue								$ 1,900,000

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Fair Value Measurements - Assets Measured at Fair Value (Details) - USD ($)	Sep. 30, 2022	Dec. 31, 2021
Fair Value, Measurements, Recurring
Investments:
Totals	$ 130,332,000	$ 220,223,000
Liabilities measured at fair value	0	0
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)
Investments:
Totals	101,177,000	125,800,000
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2)
Investments:
Totals	29,155,000	94,423,000
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3)
Investments:
Totals	0	0
Corporate debt securities | Fair Value, Measurements, Recurring
Investments:
Available-for-sale debt securities, fair value	21,419,000	86,470,000
Corporate debt securities | Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)
Investments:
Available-for-sale debt securities, fair value	0	0
Corporate debt securities | Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2)
Investments:
Available-for-sale debt securities, fair value	21,419,000	86,470,000
Corporate debt securities | Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3)
Investments:
Available-for-sale debt securities, fair value	0	0
U.S. Treasuries | Fair Value, Measurements, Recurring
Investments:
Available-for-sale debt securities, fair value	24,066,000	30,271,000
U.S. Treasuries | Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)
Investments:
Available-for-sale debt securities, fair value	24,066,000	30,271,000
U.S. Treasuries | Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2)
Investments:
Available-for-sale debt securities, fair value	0	0
U.S. Treasuries | Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3)
Investments:
Available-for-sale debt securities, fair value	0	0
Government agency securities | Fair Value, Measurements, Recurring
Investments:
Available-for-sale debt securities, fair value	7,736,000	7,953,000
Government agency securities | Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)
Investments:
Available-for-sale debt securities, fair value	0	0
Government agency securities | Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2)
Investments:
Available-for-sale debt securities, fair value	7,736,000	7,953,000
Government agency securities | Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3)
Investments:
Available-for-sale debt securities, fair value	0	0
Money market funds, included in cash equivalents
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money market funds, included in cash equivalents	77,111,000	95,529,000
Money market funds, included in cash equivalents | Fair Value, Measurements, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money market funds, included in cash equivalents	77,111,000	95,529,000
Money market funds, included in cash equivalents | Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money market funds, included in cash equivalents	77,111,000	95,529,000
Money market funds, included in cash equivalents | Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money market funds, included in cash equivalents	0	0
Money market funds, included in cash equivalents | Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money market funds, included in cash equivalents	$ 0	$ 0

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Investments - Available-for-sale Securities by Security Type (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Unrealized Gains	$ 0	$ 0
Unrealized Losses	(1,031)	(238)
Cash equivalents, short-term and long-term investments, carrying value	131,363	220,461
Cash equivalents, short-term and long-term investments, fair vale disclosure	130,332	220,223
Short-term Investments
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Unrealized Gains	0	0
Unrealized Losses	(960)	(56)
Total cash equivalents and short-term investments, carrying value	129,569	178,622
Total cash equivalents and short-term investments, fair value	128,609	178,566
Short-term Investments | Corporate debt securities
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Available-for-sale debt securities, amortized cost basis	21,741	69,316
Unrealized Gains	0	0
Unrealized Losses	(322)	(34)
Available-for-sale debt securities, fair value	21,419	69,282
Short-term Investments | U.S. Treasuries
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Available-for-sale debt securities, amortized cost basis	24,559	13,777
Unrealized Gains	0	0
Unrealized Losses	(493)	(22)
Available-for-sale debt securities, fair value	24,066	13,755
Short-term Investments | Government agency securities
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Available-for-sale debt securities, amortized cost basis	6,158
Unrealized Gains	0
Unrealized Losses	(145)
Available-for-sale debt securities, fair value	6,013
Long-term Investments
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Available-for-sale debt securities, amortized cost basis	1,794	41,839
Unrealized Gains	0	0
Unrealized Losses	(71)	(182)
Available-for-sale debt securities, fair value	1,723	41,657
Long-term Investments | Corporate debt securities
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Available-for-sale debt securities, amortized cost basis		17,276
Unrealized Gains		0
Unrealized Losses		(88)
Available-for-sale debt securities, fair value		17,188
Long-term Investments | U.S. Treasuries
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Available-for-sale debt securities, amortized cost basis		16,580
Unrealized Gains		0
Unrealized Losses		(64)
Available-for-sale debt securities, fair value		16,516
Long-term Investments | Government agency securities
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]
Available-for-sale debt securities, amortized cost basis	1,794	7,983
Unrealized Gains	0	0
Unrealized Losses	(71)	(30)
Available-for-sale debt securities, fair value	1,723	7,953
Money market funds, included in cash equivalents
Debt Securities, Available-for-sale [Line Items]
Cash equivalents at carrying value	77,111	95,529
Cash equivalents at fair value	$ 77,111	$ 95,529

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Investments - Narrative (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Investments, Debt and Equity Securities [Abstract]
Available-for-sale securities in an unrealized loss position for less than twelve months	$ 39,200,000		$ 39,200,000		$ 86,700,000
Aggregate fair value of securities in an unrealized position for more than twelve months	14,000,000		14,000,000		$ 4,800,000
Realized gains or losses on available-for-sale securities	$ 0	$ 0	$ 0	$ 0

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Restricted Cash - Narrative (Details) - USD ($) $ in Millions	Sep. 30, 2022	Dec. 31, 2021
Cash and Cash Equivalents [Abstract]
Non-current restricted cash	$ 1.3	$ 1.3

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Restricted Cash - Schedule of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021	Sep. 30, 2021	Dec. 31, 2020
Cash and Cash Equivalents [Abstract]
Cash and cash equivalents	$ 77,111	$ 95,529	$ 145,365	$ 147,493
Restricted cash	1,270	1,270	1,270	1,270
Cash, cash equivalents and restricted cash	$ 78,381	$ 96,799	$ 146,635	$ 148,763

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Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
External research, development and professional services	$ 9,749	$ 6,252
Employee compensation and benefits	6,435	6,844
Lab consumables and other	420	371
Total accrued expenses	$ 16,604	$ 13,467

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Common Stock and Preferred Stock - Narrative (Details) $ / shares in Units, $ in Millions			3 Months Ended
	Nov. 04, 2021 USD ($)	Dec. 17, 2019 USD ($)	Mar. 31, 2021 USD ($) $ / shares shares	Sep. 30, 2022 vote shares	Dec. 31, 2021 shares
Subsidiary, Sale of Stock [Line Items]
Common stock shares authorized (in shares)				160,000,000	160,000,000
Common stock, votes per share | vote				1
Sales commission percentage		3.00%
Sale of stock, shares issued (in shares)			3,156,200
Sale of stock, price per share (USD per share) | $ / shares			$ 9.87
Proceeds from stock offering, net | $			$ 30.2
Preferred stock shares authorized (in shares)				5,000,000	5,000,000
Preferred stock shares issued (in shares)				0	0
Preferred stock shares outstanding (in shares)				0	0
2019 ATM Offering
Subsidiary, Sale of Stock [Line Items]
Aggregate offering price shares | $		$ 50.0
Public Offering, March 2021
Subsidiary, Sale of Stock [Line Items]
Sale of stock, shares issued (in shares)			5,750,000
Sale of stock, price per share (USD per share) | $ / shares			$ 11.25
Proceeds from stock offering, net | $			$ 60.6
2021 ATM Offering
Subsidiary, Sale of Stock [Line Items]
Aggregate offering price shares | $	$ 75.0
Sales commission percentage	3.00%

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Common Stock and Preferred Stock - Shares Reserved for Future Issuance (Details) - shares	Sep. 30, 2022	Dec. 31, 2021	Jan. 31, 2017
Conversion of Stock [Line Items]
Common stock reserved for potential conversion (in shares)	11,342,000	9,720,000	1,753,758
Shares reserved for vesting of restricted stock units
Conversion of Stock [Line Items]
Common stock reserved for potential conversion (in shares)	1,016,000	833,000
Shares reserved for exercises of outstanding stock options
Conversion of Stock [Line Items]
Common stock reserved for potential conversion (in shares)	8,592,000	7,629,000
Shares reserved for future issuance under the 2017 Stock Option and Incentive Plan
Conversion of Stock [Line Items]
Common stock reserved for potential conversion (in shares)	1,734,000	1,258,000

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Stock-based Compensation - Narrative (Details) - USD ($) $ / shares in Units, $ in Millions			3 Months Ended			9 Months Ended
	Jan. 01, 2022	Jan. 01, 2021	Sep. 30, 2022	Jun. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021	Jan. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares of common stock eligible to be purchased (in shares)			11,342,000			11,342,000		9,720,000	1,753,758
Options granted (in shares)						1,747,000
Weighted average fair value of options granted (in dollars per share)			$ 2.20		$ 4.24	$ 4.57	$ 7.22
Exercises of common stock options (in shares)			0			71,000
Intrinsic value of stock options exercised (less than for all periods other than current period YTD)					$ 0.1	$ 0.1	$ 2.9
Unrecognized stock-based compensation expense, options			$ 13.5			$ 13.5
Shares reserved for future issuance under the 2017 Stock Option and Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares of common stock reserved for issuance (in shares)			1,733,603			1,733,603
Shares of common stock eligible to be purchased (in shares)			1,734,000			1,734,000		1,258,000
Inducement Awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted (in shares)				225,000
RSUs
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares of common stock eligible to be purchased (in shares)			1,016,000			1,016,000		833,000
Vested (in shares)			100,000		100,000	358,000
Aggregate fair value of awards vested in period						$ 2.7	$ 1.5
Unrecognized stock-based compensation expense, RSUs			$ 5.5			$ 5.5
Remaining weighted average vesting period						1 year 8 months 12 days
Employee Stock Option
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Remaining weighted average vesting period						2 years 6 months
2013 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares of common stock reserved for issuance (in shares)									0
Shares of common stock eligible to be purchased (in shares)									243,758
2017 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares of common stock eligible to be purchased (in shares)									1,510,000
Percent of outstanding shares able to be added each year									4.00%
Additional shares authorized (in shares)	2,050,601	1,669,162
2017 Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares of common stock eligible to be purchased (in shares)									302,000
Percent of outstanding shares able to be added each year									1.00%
Additional shares authorized (in shares)	512,650	417,291
Shares of common stock to determine number of additional shares (in shares)									603,000

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Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense	$ 2,560	$ 2,926	$ 7,832	$ 8,686
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense	1,254	1,628	3,913	4,129
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense	$ 1,306	$ 1,298	$ 3,919	$ 4,557

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Stock-based Compensation - RSU Activity (Details) - RSUs - $ / shares	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022
RSUs
Beginning unvested balance (in shares)			833,000
Issued (in shares)			670,000
Vested (in shares)	(100,000)	(100,000)	(358,000)
Cancelled (in shares)			(129,000)
Ending unvested balance (in shares)	1,016,000		1,016,000
Weighted-Average Grant Date Fair Value per Share
Beginning unvested balance (in dollars per share)			$ 9.13
Issued (in dollars per share)			7.25
Vested (in dollars per share)			8.15
Cancelled (in dollars per share)			8.59
Ending unvested balance (in dollars per share)	$ 8.31		$ 8.31

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Stock-based Compensation - Weighted Average Assumptions (Details) - Employee Stock Option	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-free interest rate	2.90%	1.00%	2.00%	0.80%
Expected dividend yield	0.00%	0.00%	0.00%	0.00%
Expected term (in years)	6 years 1 month 6 days	6 years 1 month 6 days	6 years	6 years
Expected volatility	80.70%	82.00%	80.90%	81.90%

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Stock-based Compensation - Stock Option Activity (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended	9 Months Ended	12 Months Ended
	Sep. 30, 2022	Sep. 30, 2022	Dec. 31, 2021
Options
Beginning outstanding balance (in shares)		7,629
Granted (in shares)		1,747
Exercised (in shares)	0	(71)
Cancelled or forfeited (in shares)		(713)
Ending outstanding balance (in shares)	8,592	8,592	7,629
Exercisable (in shares)	5,751	5,751
Weighted-Average Exercise Price
Beginning outstanding balance (in dollars per share)		$ 8.87
Granted (in dollars per share)		6.57
Exercised (in dollars per share)		5.49
Cancelled or forfeited (in dollars per share)		9.29
Ending outstanding balance (in dollars per share)	$ 8.39	8.39	$ 8.87
Exercisable (in dollars per share)	$ 8.77	$ 8.77
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Remaining contractual life, outstanding (in years)		6 years 4 months 24 days	6 years 4 months 24 days
Remaining contractual life, exercisable (in years)		5 years 1 month 6 days
Aggregate intrinsic value, outstanding	$ 1,255	$ 1,255	$ 16,881
Aggregate intrinsic value, exercisable	$ 1,255	$ 1,255

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Related-party Transactions (Details) - USD ($)	1 Months Ended		3 Months Ended
	Oct. 31, 2020	Aug. 31, 2020	Mar. 31, 2021	Sep. 30, 2022
Related Party Transaction [Line Items]
Proceeds from stock offering, net			$ 30,200,000
Sale of stock, shares issued (in shares)			3,156,200
Gilead Transaction Agreements
Related Party Transaction [Line Items]
Non-refundable upfront payment received	$ 85,000,000
Gilead Sciences, Inc. | Gilead Transaction Agreements | Gilead Transaction Agreements
Related Party Transaction [Line Items]
Non-refundable upfront payment received	$ 85,000,000	$ 85,000,000
Reimbursable expenses due from related party				$ 0
Gilead Sciences, Inc. | Gilead Stock Purchase Agreement | Gilead Transaction Agreements
Related Party Transaction [Line Items]
Proceeds from stock offering, net		$ 35,000,000
Gilead Sciences, Inc. | Gilead Stock Purchase Agreement | Gilead Transaction Agreements | Common Stock
Related Party Transaction [Line Items]
Sale of stock, shares issued (in shares)		5,539,727

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Net Loss per Share - Schedule of Antidilutive Securities Excluded from Computation of Net Loss per Share (Details) - shares shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of net loss per share (in shares)	9,645	8,381	9,548	8,055
Outstanding stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of net loss per share (in shares)	8,646	7,559	8,567	7,284
RSUs
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of net loss per share (in shares)	999	822	981	771

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Subsequent Events (Details) - Gilead Transaction Agreements - GS-1811 License - USD ($) $ in Millions	1 Months Ended
	Oct. 31, 2022	Jun. 30, 2021
Subsequent Event [Line Items]
Milestone achievement earned		$ 25.0
Subsequent Event
Subsequent Event [Line Items]
Milestone achievement earned	$ 15.0