PYXIS TANKERS INC.

59 K. Karamanli Street

15125 Maroussi, Greece

May 21, 2021

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, NE

Washington, D.C. 20549

Re: Pyxis Tankers Inc.
Registration Statement on Form F-3 (No. 333-256167)

Ladies and Gentlemen:

The undersigned registrant hereby requests that the effectiveness of the above captioned Registration Statement, filed with the United States Securities and Exchange Commission on Form F-3 on May 14, 2021, as thereafter amended, be accelerated so that it will be made effective at 5:00 p.m. Eastern Time on May 25, 2021, or as soon thereafter as practicable, pursuant to Rule 461(a) of the Securities Act of 1933, as amended (the “Act”).

The undersigned registrant is aware of its obligations under the Act.

Should you have any questions regarding this request, please do not hesitate to contact Keith Billotti at (212) 574-1274, of Seward & Kissel LLP, counsel to the undersigned registrant.

Yours truly,
PYXIS TANKERS INC.
By:	/s/ Henry P. Williams
	Name: Henry P. Williams
	Title:   Chief Financial Officer