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Commitments and Contingencies - Gemphire Contingent Value Rights Agreement (Details) - USD ($)
$ in Thousands
Mar. 31, 2022
Mar. 23, 2021
Dec. 30, 2019
Commitments and Contingencies      
Percentage of proceeds from the grant, sale, or transfer of rights   10.00% 80.00%
Amount of milestones accrued $ 0