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Commitments and Contingencies - Pfizer License Agreement (Details) - USD ($)
Jun. 30, 2019
Dec. 31, 2018
Dec. 31, 2017
Commitments and Contingencies      
No liabilities were recorded related to the license agreement $ 2,050,000 $ 11,920,000 $ 15,076,000
Pfizer, Inc.      
Commitments and Contingencies      
No liabilities were recorded related to the license agreement $ 0